【81171646】痕量Tau蛋白标记检出方案设计及其相关基础过程研究国家自然基金项目

痕量Tau蛋白标记检出方案设计及其相关基础过程研究

项目批准号： 81171646

批准年份： 2011

学科分类： H2601.生物化学检验

项目负责人：姚天明

资助类别：面上项目

负责人职称：教授

依托单位：同济大学

资助金额： 58万元

关键词：检测;Tau蛋白;Alzheimer病;纳米传感器;免疫分析

起止时间： 2012-01-01到2015-12-31

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序号	标题	类型	作者
1	Study on the abnormal aggregation of Tau protein, and the ultrasensitive / selective detection of AD biomarker	会议论文
2	[Ru(bpy)2dppz-idzo]2+: a colorimetric molecular “light switch” and powerful stabilizer for G-quadruplex DNA	期刊论文	高星\|孙文亮\|石硕\|姚天明\|
3	Two structurally analogous ruthenium complexes as naked-eye and reversible molecular "light switch" for G-quadruplex DNA	期刊论文	姚君亮\|高星\|黄海量\|姚天明\|
4	Molecular "light switch" for G-quadruplex DNA: cycling the switch on and off	期刊论文	Yao, Junliang\|Sun, Wenliang\|Yao, Tianming\|Ji, Liangnian\|
5	Ultrasensitive fluorescence detection of heparin based on quantum dots and a functional ruthenium polypyridyl complex	期刊论文	石硕\|王林林\|姚君亮\|姚天明\|
6	[Ru(bpy)(2)(bppp)](2+) binds two different forms of the human telomeric G-quadruplex structure	期刊论文	Sun, Wenliang\|Huang, Hailing\|Yao, Tianming\|Ji, Liangnian\|
7	A comparative study of the interaction of two structurally analogous ruthenium complexes with human telomeric G-quadruplex DNA	期刊论文	赵娟\|孙文亮\|姚天明\|计亮年\|
8	[Ru(bpy)(2)dppz-idzo](2+): a colorimetric molecular "light switch" and powerful stabilizer for G-quadruplex DNA	期刊论文	Gao, Xing\|Sun, Wenliang\|Shi, Shuo\|Yao, Tian-Ming\|
9	Sensitive detection for coralyne and mercury ions based on homo-A/T DNA by exonuclease signal amplification	期刊论文	黄海量\|石硕\|郑絮月\|姚天明\|
10	Promotion and Inhibition Factors in Tau Protein Aggregation	会议论文
11	A label-free fluorescent probe for Hg2+ and biothiols based on graphene oxide and Ru-complex	期刊论文	姚天明\|石硕\|曹艳林\|孙文亮\|
12	A molecular light switch Ru complex and quantum dots for the label-free, aptamer-based detection of thrombin	期刊论文	Sun, Wenliang\|Yao, Tianming\|Shi, Shuo\|
13	A Naked-Eye On–Off–On Molecular “Light Switch” Based on a Reversible “Conformational Switch“of G？Quadruplex DNA	期刊论文	Wenliang Sun\|Xue-Zhong Fan\|Shuo Shi\|Tian-Ming Yao\|
14	A universall abel-free fluorescent aptasensor based on Ru complex and quantum dots for adenosine, dopamine and 17β-estradiol detection	期刊论文	朱影\|吴学文\|臧瑞敏\|姚天明\|
15	A comparative study of the interaction of two structurally analogous ruthenium complexes with human telomeric G-quadruplex DNA	期刊论文	Zhao, Juan\|Sun, Wen-Liang\|Yao, Tian-Ming\|Ji, Liang-Nian\|
16	Molecular “light switch” [Ru(phen)2dppzidzo]2+monitoring the aggregation of tau	期刊论文	王林林\|姚君亮\|石硕\|姚天明\|
17	Impacts of terminal modification of [Ru(phen)2dppz]2+ on the luminescence properties: a theoretical study	期刊论文	石硕\|姚君亮\|赵娟\|姚天明\|
18	A label-free fluorescent probe for Hg2+ and biothiols based on graphene oxide and Ru-complex	期刊论文	姚天明\|石硕\|曹艳林\|孙文亮\|
19	[Ru(bpy)2(bppp)]2+ binds two different forms of the human telomeric G-quadruplex structure	期刊论文	孙文亮\|黄海量\|姚天明\|计亮年\|
20	Label-free fluorescent DNA sensor for the detection of silver ions based on molecular light switch Ru complexand unmodified quantum dots	期刊论文	孙文亮\|姚君亮\|姚天明\|石硕\|
21	Ultrasensitive fluorescence detection of heparin based on quantum dots and a functional ruthenium polypyridyl complex	期刊论文	石硕\|王林林\|姚君亮\|姚天明\|
22	Graphene oxide–Ru complex for label-free assay of DNA sequence and potassium ions via fluorescence resonance energy transfer	期刊论文	Wenliang Sun\|Shuo Shi \|Tianming Yao*\|
23	Label-free fluorescent DNA biosensors based on metallointercalators and nanomaterials	期刊论文	Wenliang Sun\|Xiangyang Wang\|Yao Tianming\|Liangnian Ji\|
24	Molecular “light switch” for G-quadruplex DNA: cycling the switch on and off	期刊论文	姚君亮\|孙文亮\|姚天明\|计亮年\|
25	A RET-supported logic gate combinatorial library to enable modeling and implementation of intelligent logic functions	期刊论文	石硕\|朱影\|黄海量\|姚天明\|
26	Two structurally analogous ruthenium complexes as naked-eye and reversible molecular “light switch” for G-quadruplex DNA	期刊论文	姚君亮\|高星\|黄海量\|姚天明\|
27	Targeting Human Telomeric G-Quadruplex DNA and Inhibition of Telomerase Activity With [(dmb)2Ru(obip)Ru(dmb)2]4+	期刊论文	吕春燕\|黄海量\|徐俊\|姚天明\|
28	Graphene oxide–Ru complex for label-free assay of DNA sequence and potassium ions via fluorescence resonance energy transfer	期刊论文	孙文亮\|石硕\|姚天明\|
29	A Naked-Eye On？Off？On Molecular “Light Switch” Based on a Reversible “Conformational Switch” of G？Quadruplex DNA	期刊论文	孙文亮\|Fan Xue-Zhong\|石硕\|姚天明\|
30	Ultrasensitive and universal fluorescent aptasensor for the detection of biomolecules (ATP,adenosine and thrombin)based on DNA/Ag nanoclusters fluorescence light-up system	期刊论文	黄海量\|朱艳艳\|吕晓艳\|姚天明\|
31	Cu 2t modulated silver nanoclusters as an on–off–on fluorescence probe for the selective detection of L -histidine	期刊论文	郑絮月\|姚天明\|朱影\|石硕\|
32	Cu2+ modulated silver nanoclusters as an on–off–on fluorescence probe for the selective detection of L-histidine	期刊论文	郑絮月\|姚天明\|朱影\|石硕\|
33	Molecular Hairpin: A Possible Model for Inhibition of Tau Aggregation by Tannic Acid	期刊论文	Sun, Wenliang\|Yao, Tianming\|Shi, Shuo\|Ji, Liangnian\|
34	A molecular light switch Ru complex and quantum dots for the label-free, aptamer-based detection of thrombin	期刊论文	孙文亮\|姚天明\|石硕\|
35	基于新型钌配合物分子光开关的非标记型荧光生物传感器研究	会议论文
36	A new fluorescence “switch on” assay for heparin detection by using a functional ruthenium polypyridylcomplex	期刊论文	高星\|孙文亮\|石硕\|姚天明\|
37	Targeting Human Telomeric G-Quadruplex DNA and Inhibition of Telomerase Activity With [(dmb)2Ru(obip)Ru(dmb)2]4+	期刊论文	Lv Chunyan\|Huang Hailiang\|Xu Jun\|Yao Tianming\|
38	Label-free fluorescent DNA biosensors based on metallointercalators and nanomaterials	期刊论文	孙文亮\|王相阳\|姚天明\|计亮年\|
39	A new fluorescence "switch on" assay for heparin detection by using a functional ruthenium polypyridyl complex	期刊论文	Gao, Xing\|Sun, Wenliang\|Shi, Shuo\|Yao, Tian-Ming\|
40	Effect of the Ancillary Ligands on the Spectral Properties and G-Quadruplexes DNA Binding Behavior: A CombinedExperimental and Theoretical Study	期刊论文	高星\|黄海量\|赵娟\|姚天明\|
41	Binding Behaviors for Different Types of DNA G-Quadruplexes: Enantiomers of [Ru(bpy)2(L)]2+ (L=dppz, dppz-idzo)	期刊论文	徐进红\|高星\|黄海量\|姚天明\|
42	基于钌多吡啶类配合物的DNA 分子光开关及生物传感研究	期刊论文	石硕\|姚天明\|计亮年\|
43	A comparative study of the interaction of two structurally analogous ruthenium complexes with human telomeric G-quadruplex DNA	期刊论文	Juan Zhao\|Wen-Liang Sun\|Tian-Ming Yao\|Liang-Nian Ji\|
44	Label-free fluorescent DNA sensor for the detection of silver ions based on molecular light switch Ru complex and unmodified quantum dots	期刊论文	Wenliang Sun\|Junliang Yao\|Tianming Yao\|Shuo Shi\|
45	Construct Tau Aggregation Inhibitorby Thio-Ene Click Chemistry of Docosahexaenoic Acid	会议论文

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