Sirt6调控心肌细胞p53及其下游相关氧化应激和死亡信号通路抑制阿霉素心肌损伤的机制研究
81870221
2018
H0202.心肌损伤、修复、重构和再生
蒋维
面上项目
研究员
四川大学
57万元
氧化应激;Sirt6;p53;细胞死亡;阿霉素心脏毒性
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Sirt6 protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting P53/Fas-dependent cell death and augmenting endogenous antioxidant defense mechanisms | 期刊论文 | Sisi Wu;Jie Lan;Lingyu Li;Xiaoxiao Wang;Mingming Tong;Li Fu;Yanjing Zhang;Jiayi Xu;Xuemei Chen;Hongying Chen;Ruli Li;Yao Wu;Juanjuan Xin;Xin Yan;He Li;Kunyue Xue;Xue Li;Caili Zhuo;Wei Jiang |
| 2 | Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases | 期刊论文 | Siyu He;Hong Jiang;Caili Zhuo;Wei Jiang |
| 3 | Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway | 期刊论文 | Lan Zhan;Xiangxiu Wang;Yanjing Zhang;Guonian Zhu;Yu Ding;Xuemei Chen;Wei Jiang;Sisi Wu |
| 4 | Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis | 期刊论文 | He Li;Linling Liu;Hong-ying Chen;Xin Yan;Ru-li Li;Jie Lan;Kun-yue Xue;Xue Li;Cai-li Zhuo;Lan Lin;Ling-yu Li;Zhuang Wu;Die Zhang;Xue-mei Wang;Wen-jing Huang;Yingling Wang;Wei Jiang;Liming Zhou |
| 5 | Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells. | 期刊论文 | Yu Ding;Sisi Wu;Yuwei Huo;Xuemei Chen;Li Chai;Yan Wang;Xiangxiu Wang;Guonian Zhu;Wei Jiang |
| 6 | Prim-O-glucosycimifugin attenuates liver injury in septic mice by inhibiting NLRP3 inflammasome/caspase-1 signaling cascades in macrophages. | 期刊论文 | Lin-ling Liu;Xin Yan;Kun-yue Xue;Xue-mei Wang;Ling-yu Li;Hong-ying Chen;Ru-li Li;He Li;Jie Lan;Juan-juan Xin;Xizhe Li;Cai-li Zhuo;Zhuang Wu;Die Zhang;Wen-jing Huang;Ying-ling Wang;Xizhe Li;Wei Jiang;Heng-yu Zhang |
| 7 | Research progress of pharmacological effects of Siraitia grosvenorii extract | 期刊论文 | He Li;Ruli Li;Wei Jiang;Liming Zhou |
| 8 | 5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling. | 期刊论文 | Jia-Xiang Chen;Kunyue Xue;Juanjuan Xin;Xin Yan;Ru-Li Li;Xiao-Xiao Wang;Xu-Lei Wang;Ming-ming Tong;Lu Gan;He Li;Jie Lan;Xue Li;Cai-li Zhuo;Ling-yu Li;Zi-jie Deng;Heng-Yu Zhang;Wei Jiang |
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