基于病毒介导基因编辑的孤独症非人灵长类模型建立及神经环路研究
91732302
2017
H0901.神经系统发育与代谢异常
仇子龙
重大研究计划
研究员
中国科学院脑科学与智能技术卓越创新中心
300万元
光遗传学;孤独症谱系障碍;神经环路;基因编辑;非人灵长类模型
2018-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice | 期刊论文 | Cheng Cheng;Yang Kan;Wu Xinwei;Zhang Yuefang;Shan Shifang;Gitler Aaron;Ghosh Anirvan;Qiu Zilong |
| 2 | Expanding C-T base editing toolkit with diversified cytidine deaminases. | 期刊论文 | Cheng Tian Lin;Li Shuo;Yuan Bo;Wang Xiaolin;Zhou Wenhao;Qiu Zilong |
| 3 | The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice. | 期刊论文 | Tong Da Li;Chen Rui Guo;Lu Yu Lan;Li Wei Ke;Zhang Yue Fang;Lin Jun Kai;He Ling Jie;Dang Ting;Shan Shi Fang;Xu Xiao Hong;Zhang Yi;Zhang Chen;Du Ya Song;Zhou Wen Hao;Wang Xiaoqun;Qiu Zilong |
| 4 | Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN | 期刊论文 | Zhang Lei;Xue Zhenyu;Liu Qidong;Liu Yunbo;Xi Siwei;Cheng Yanyong;Li Jingjie;Yan Jia;Shen Yuan;Xiao Chong;Xie Zhongcong;Qiu Zilong;Jiang Hong |
| 5 | In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. | 期刊论文 | Cai Yuan;Cheng Tianlin;Yao Yichuan;Li Xiao;Ma Yuqian;Li Lingyun;Zhao Huan;Bao Jin;Zhang Mei;Qiu Zilong;Xue Tian |
| 6 | Enrichment of shortmutant cell-free DNA fragments enhanced detection of pancreatic cancer | 期刊论文 | Liu Xiaoyu;Liu Lingxiao;Ji Yuan;Li Changyu;Wei Tao;Yang Xuerong;Zhang Yuefang;Cai Xuyu;Gao Yangbin;Xui Weihong;Rao Shengxiang;Jin Dayong;Lou Wenhui;Qiu Zilong;Wang Xiaolin |
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