半克隆技术介导肌强直性营养不良小鼠模型的建立
81672117
2016
H0601.运动系统结构、功能和发育异常
李劲松
面上项目
研究员
中国科学院分子细胞科学卓越创新中心
85万元
强直性肌营养不良症;半克隆技术;小鼠;单倍体胚胎干细胞
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 2017年中国科学院优秀导师奖 | 奖励 | 李劲松 |
| 2 | CRISPR-Cas9-mediated genome-editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development | 期刊论文 | Wang L;Li MY;Qu C;Miao WY;Yin Q;Liao J;Cao HT;Huang M;Wang K;Zuo E;Peng G;Zhang SX;Chen G;Li Q;Tang K;Yu Q;Li Z;Wong C;Xu G;Jing N;Yu X;Li Jinsong |
| 3 | 2019年(第十八届)上海市医学科技奖一等奖《女性生殖障碍疾病防治和辅助生殖助孕策略优化及推广应用》 | 奖励 | 孙贇;杜艳芝;胡双纲;朱琴玲;齐家;金颖;李劲松;杨辉;章美玲;洪燕 |
| 4 | Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development | 期刊论文 | Yang Xianfa;Hu Boqiang;Liao Jiaoyang;Qiao Yunbo;Chen Yingying;Qian Yun;Feng Su;Yu Fang;Dong Ji;Hou Yu;Xu He;Wang Ran;Peng Guangdun;Li Jinsong;Tang Fuchou;Jing Naihe |
| 5 | The evolving CRISPR technology | 期刊论文 | Yan Meng;Li Jinsong |
| 6 | Temporal regulation of prenatal embryonic development by paternal imprinted loci. | 期刊论文 | Li Qing;Li Yuanyuan;Yin Qi;Huang Shuo;Wang Kai;Zhuo Liangchai;Li Wei;Chang Boran;Li Jinsong |
| 7 | Technical advances contribute to the study of genomic imprinting | 期刊论文 | Li Yuanyuan;Li Jinsong |
| 8 | 促进肌肉干细胞分化的化合物及其应用 | 专利 | 李劲松;胡苹;王红叶;尹奇;李钠;丁一夫;李升 |
| 9 | 2019年上海市科技精英提名奖 | 奖励 | 李劲松 |
| 10 | 2017年“上海市自然科学一等奖”《卵子介导细胞重编程的基础与应用研究》 | 奖励 | 李劲松 |
| 11 | Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene-editing | 期刊论文 | Leixin Wei;Xiukun Wang;Suming Yang;Wen Yuan;Li Jinsong |
| 12 | In vitro expansion of human sperm through nuclear transfer | 期刊论文 | Zhang Xiaoyu Merlin;Wu Keliang;Zheng Yuxuan;Zhao Han;Gao Junpeng;Hou Zhenzhen;Zhang Meiling;Liao Jiaoyang;Zhang Jingye;Gao Yuan;Li Yuanyuan;Li Lin;Tang Fuchou;Chen Zi-Jiang;Li Jinsong |
| 13 | PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis | 期刊论文 | Wang Xiukun;Kang Jun Yan;Wei Leixin;Yang Xiaogan;Sun Hongduo;Yang Suming;Lu Lei;Yan Meng;Bai Meizhu;Chen Yanyan;Long Juanjuan;Li Na;Li Dangsheng;Huang Jing;Lei Ming;Shao Zhen;Yuan Wen;Zuo Erwei;Lu Kehuan;Liu Mo Fang;Li Jinsong |
| 14 | CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells | 期刊论文 | Wang Y;Ding Y;Li Jinsong |
| 15 | CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development | 期刊论文 | Li Qing;Li Y;Yang S;Huang S;Yan M;Ding Y;Tang W;Lou X;Yin Q;Sun Z;Lu L;Shi H;Wang H;Chen Y;Li Jinsong |
| 16 | Haploid embryonic stem cells can be enriched and maintained by simple filtration | 期刊论文 | Chao Qu;Meng Yan;Suming Yang;Lingbo Wang;Qi Yin;Yuan Liu;Yeguang Chen;Li Jinsong |
| 17 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1 | 期刊论文 | Yin Qi;Wang Hongye;Li Na;Ding Yifu;Xie Zhenfei;Jin Lifang;Li Yan;Wang Qiong;Liu Xinyi;Xu Liuqing;Li Qing;Ma Yongjian;Cheng Yanbo;Wang Kai;Zhong Cuiqing;Yu Qian;Tang Wei;Chen Wanjin;Yang Wenjun;Zhang Fan;Ding Chen;Bao Lan;Zhou Bin;Hu Ping;Li Jinsong |
| 18 | Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development | 期刊论文 | Bai Meizhu;Han Yujiao;Wu Yuxuan;Liao Jiaoyang;Li Lin;Wang Lijun;Li Qing;Xing Wenhui;Chen Luonan;Zou Weiguo;Li Jinsong |
| 19 | 2019年中国科学院朱李月华优秀教师奖 | 奖励 | 李劲松 |
| 20 | Genome tagging project: tag every protein in mouse through “artificial spermatids” | 期刊论文 | Jiang Jing;Yan Meng;Li Dangsheng;Li Jinsong |
| 21 | Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy | 期刊论文 | Wu Keliang;Zhong Cuiqing;Chen Tailai;Zhang Xiaoyu;Tao Wenrong;Zhang Jingye;Li Hongchang;Zhao Han;Li Jinsong;Chen Zi Jiang |
| 22 | An intermediate cell state allows rerouting of cell fate | 期刊论文 | Wang X;Li Jinsong |
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