【81130076】中枢神经系统感应氨基酸及调控脂质代谢的分子机制研究国家自然基金项目

中枢神经系统感应氨基酸及调控脂质代谢的分子机制研究

项目批准号： 81130076

批准年份： 2011

学科分类： H0709.能量代谢调节异常与肥胖

项目负责人：郭非凡

资助类别：重点项目

负责人职称：研究员

依托单位：中国科学院上海营养与健康研究所

资助金额： 240万元

关键词：脂质代谢;氨基酸;营养素感应;能量代谢;中枢神经系统

起止时间： 2012-01-01到2016-12-31

中英文摘要
结题摘要
结题报告
项目成果
项目参与人

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序号	标题	类型	作者
1	MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4	期刊论文	Deng Jiali\|Chen Shanghai\|Wang Chunxia\|Guo Feifan\|
2	Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure	期刊论文	Chen Shanghai\|Chen Shanghai\|Guo Feifan\|Guo Feifan\|
3	A Novel Function of MicroRNA 130a-3p in Hepatic Insulin Sensitivity and Liver Steatosis	期刊论文	Lu Yingli\|Xiao Yuzhong\|Zhang Zhou\|Guo Feifan\|
4	Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice	期刊论文	Chen Shanghai\|Zhu Jianmin\|Sheng Hongguang\|Guo Feifan\|
5	A novel function of B-cell translocation gene 1 (BTG1) in the regulation of hepatic insulin sensitivity in mice via c-Jun	期刊论文	Yu Junjie\|Guo Yajie\|Chen Shanghai\|Guo Feifan\|
6	BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism	期刊论文	Yuan Feixiang\|Yu Junjie\|Chen Shanghai\|Guo Feifan\|
7	S6K1 in the Central Nervous System Regulates Energy Expenditure via MC4R/CRH Pathways in Response to Deprivation of an Essential Amino Acid	期刊论文	Xiao Fei\|Liu Bin\|Chen Shanghai\|Guo Feifan\|
8	A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPAR alpha	期刊论文	Yuan Feixiang\|Liu Yong\|Chen Shanghai\|Guo Feifan\|
9	Central prolactin receptors (PRLRs) regulate hepatic insulin sensitivity in mice via signal transducer and activator of transcription 5 (STAT5) and the vagus nerve	期刊论文	Li Kai\|Liu Bin\|Chen Shanghai\|Guo Feifan\|
10	MAPK1/3 regulate hepatic lipid metabolism via ATG7-dependent autophagy	期刊论文	Chen Yan\|Chen Yan\|Guo Feifan\|Guo Feifan\|
11	Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress	期刊论文	Li Houkai\|Liu Bin\|Chen Shanghai\|Guo Feifan\|
12	PRLR Regulates Hepatic Insulin Sensitivity in Mice via STAT5	期刊论文	Chen Shanghai\|Li Kai\|Du Ying\|Guo Feifan\|
13	MAPK1/3 regulate hepatic lipid metabolism via ATG7-dependent autophagy	期刊论文	Chen Yan\|Chen Yan\|Guo Feifan\|Guo Feifan\|
14	Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure	期刊论文	Chen Shanghai\|Chen Shanghai\|Guo Feifan\|Guo Feifan\|
15	Leptin Signaling Is Required for Leucine Deprivation-enhanced Energy Expenditure	期刊论文	Jiang Lei\|Chen Shanghai\|Liu Yong\|Guo Feifan\|
16	Hepatic phosphoserine aminotransferase 1 (PSAT1) regulates insulin sensitivity in mice via tribbles homolog 3 (TRB).	期刊论文	Li Kai\|Wang Chunxia\|Chen Shanghai\|Guo Feifan\|
17	Knockout of inositol-requiring enzyme 1 alpha in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure	期刊论文	Liu Bin\|Chen Shanghai\|Liu Yong\|Guo Feifan\|
18	Effects of essential amino acids on lipid metabolism in mice and humans.	期刊论文	Sheng Hongguang\|Sheng Hongguang\|Guo Feifan\|Guo Feifan\|
19	Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in Mice	期刊论文	Deng Jiali\|Chen Shanghai\|Wang Chunxia\|Guo Feifan\|
20	Hepatic serum- and glucocorticoid-induced protein kinase 1 (SGK1) regulates insulin sensitivity in mice via ERK1/2	期刊论文	Geza Fejes-Toth\|Geza Fejes-Toth\|Guo Feifan\|Guo Feifan\|
21	Effects of essential amino acids on lipid metabolism in mice and humans.	期刊论文	Sheng Hongguang\|Sheng Hongguang\|Guo Feifan\|Guo Feifan\|
22	CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid	期刊论文	Chen Shanghai\|Liu Yong\|Chen Yan\|Guo Feifan\|
23	上海市自然科学三等奖	奖励	夏婷婷\|夏婷婷\|肖斐\|肖斐\|
24	Hepatic serum- and glucocorticoid-induced protein kinase 1 (SGK1) regulates insulin sensitivity in mice via ERK1/2	期刊论文	Geza Fejes-Toth\|Geza Fejes-Toth\|Guo Feifan\|Guo Feifan\|
25	Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase	期刊论文	Yu Junjie\|Chen Shanghai\|Fang Jing\|Guo Feifan\|
26	Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve	期刊论文	Xia Tingting\|Xiao Fei\|Chen Shanghai\|Guo Feifan\|
27	Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor-Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy	期刊论文	Guo Yajie\|Chen Shanghai\|Chen Yan\|Guo Feifan\|
28	上海市自然科学三等奖	奖励	夏婷婷\|夏婷婷\|肖斐\|肖斐\|
29	ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression	期刊论文	Chen Shanghai\|Huang Zhiying\|Liu Bin\|Guo Feifan\|

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