以细胞膜磷脂酰丝氨酸为靶点的生物药物的发现、功能及优化改造

81630092
2016
H34.药物学
华子春
重点项目
教授
常州南京大学高新技术研究院
275万元
磷脂酰丝氨酸;蛋白质结构与功能;膜联蛋白;细胞凋亡;毒性
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 FADD Phosphorylation Modulates Blood Glucose Levels by Decreasing the Expression of Insulin-Degrading Enzyme 期刊论文 Lin Yan;Liu Jia;Chen Jia;Yao Chun;Yang Yunwen;Wang Jie;Zhuang Hongqin;Hua Zi-Chun
2 Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression 期刊论文 Chen Xiao;Li Wei;Xu Chengchao;Wang Jie;Zhu Bo;Huang Qilai;Chen Dianhua;Sheng Jianfei;Zou Yong;Lee Yew Mun;Tan Renxiang;Shen Pingping;Wong Yin Kwan;Lin Qingsong;Wang Jigang;Hua Zichun
3 Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy 期刊论文 Zhang Xuerui;Song Lulu;Li Lin;Zhu Banghui;Huo Lina;Hu Zhaoqing;Wang Xinran;Wang Jie;Gao Mengyue;Zhang Jing;Hua Zichun
4 ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradation 期刊论文 Zhang Xuerui;Hu Zhaoqing;Wang Xinran;Li Lin;Zhu Banghui;Lin Xiaolei;Zhang Jing;Hua Zichun
5 RuvBL1 Maintains Resistance to TRAIL-Induced Apoptosis by Suppressing c-Jun/AP-1 Activity in Non-Small Cell Lung Cancer 期刊论文 Li Hao;Zhou Taoran;Zhang Yue;Jiang Hengyi;Zhang Jing;Hua Zichun
6 膜联蛋白A5在疾病诊断与新药开发中的应用前景 期刊论文 高梦月;黄张建;华子春
7 多肽药物研发关键技术及多肽创新药物的研发 奖励 华子春
8 Clinical efficacy and toxicity of PEG-asparaginase in patients with solid tumor and ALL: a meta-analysis 期刊论文 Lin Yan;Yu Wen Liang;Xu Pei Pei;Zhao Quan;Hua Zi Chun
9 Microbial Infections and Cancer Therapy 专著 华子春
10 抗菌肽urumin与甲型流感病毒H1N1 HA蛋白的相互作用研究 期刊论文 李红梅;郑伟娟;李家璜;华子春
11 Method of Anaerobic Tissue-targeted Gene Expression Initiated by Alcohol Dehydrogenase Promoter and the Application Thereof 专利 华子春
12 一种增强肿瘤对药物敏感性的方法 专利 华子春
13 Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity 期刊论文 Zhang Xiangyu;Chen Jia;Cheng Cheng;Li Ping;Cai Fangfang;Xu Huangru;Lu Yanyan;Cao Nini;Liu Jia;Wang Jigang;Hua Zi-Chun;Zhuang Hongqin
14 Annexin A5 is essential for PKC theta translocation during T-cell activation 期刊论文 Hu Zhaoqing;Li Lin;Zhu Banghui;Huang Yi;Wang Xinran;Lin Xiaolei;Li Maoxia;Xu Peipei;Zhang Xuerui;Zhang Jing;Hua Zichun
15 Quantification of a cell culture contaminant using 16S rDNA 期刊论文 Xu Xuebo;Lai Yueyang;Zhou Wenzhao;Wu Leyang;Hua Zichun
16 一种膜联蛋白V的应用 专利 华子春
17 The Differential and Dynamic Progression of Hepatic Inflammation and Immune Responses During Liver Fibrosis Induced bySchistosoma japonicumor Carbon Tetrachloride in Mice 期刊论文 Song Li-Jun;Yin Xu-Ren;Mu Sha-Sha;Li Jia-Huang;Gao Hong;Zhang Ying;Dong Pan-Pan;Mei Cong-Jin;Hua Zi-Chun
18 Highly efficient siRNA transfection in macrophages using apoptotic body-mimic Ca-PS lipopolyplex 期刊论文 Lai Yueyang;Xu Xuebo;Zhu Zhenyu;Hua Zichun
19 黄色荧光蛋白的结构对Annexin A5凋亡检测功能的影响探究 期刊论文 高梦月;王云轲;黄先杰;张晶;华子春
20 分子动力学模拟探讨Annexin A5的N-末端对其结构的影响 期刊论文 司孝磊;王杰;李家璜;华子春
21 Evaluation of mycoplasma removal reagents using qPCR-based quantification 期刊论文 Lai Yueyang;Xu Xuebo;Yan Ruiying;Hua Zichun
22 一种磷脂酰丝氨酸在制备治疗炎症性肠病药物中的应用 专利 华子春
23 A protective role for FADD dominant negative (FADD-DN) mutant in trinitrochlorobenzene (TNCB)-induced murine contact hypersensitivity reactions 期刊论文 Zhang X.;Han Y.;Song L.;Huo L.;Lai X.;Zhang Y.;Zhang J.;Hua Z.
24 Protective role of nano-selenium-enriched Bifidobacterium longum in delaying the onset of streptozotocin-induced diabetes 期刊论文 Lin Yan;Ren Yongzhe;Zhang Yan;Zhou Junjie;Zhou Feng;Zhao Quan;Xu Genxing;Hua Zichun
25 胞外基质降解产物的抗肿瘤作用、蛋白质工程改造及其应用 奖励 华子春
26 Apoptosis and apoptotic body: disease message and therapeutic target potentials 期刊论文 Xu Xuebo;Lai Yueyang;Hua Zi-Chun
27 一种阿霉素与膜联蛋白V偶联物及其制备方法和应用 专利 华子春
28 Domain IV of Annexin A5 Is Critical for Binding Calcium and Guarantees Its Maximum Binding to the Phosphatidylserine Membrane 期刊论文 Wang Jie;Liu Jing;Cao Yulu;Hu Minjin;Hua Zichun
29 阿司匹林通过ERK信号通路诱导H1299细胞凋亡 期刊论文 张翔宇;陈佳;华子春;庄红芹
30 一种18F标记的Cys-Annexin V的方法及其应用 专利 华子春
31 Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor Microenvironment 期刊论文 华子春
32 基于胰高血糖素样肽-1的多重受体激动剂的研究进展 期刊论文 钱海;李承业;华子春
33 人膜联蛋白V变体及其表达、制备和应用 奖励 华子春
34 Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-kappa B Pathway 期刊论文 Chen Xiao;Wong Yin Kwan;Lim Teck Kwang;Lim Wei Hou;Lin Qingsong;Wang Jigang;Hua Zichun
35 Targeted delivery and release of doxorubicin using a pH-responsive and self-assembling copolymer 期刊论文 Huang Kaizong;Zhu Lingli;Wang Yunke;Mo Ran;Hua Zichun
36 Lentiviral delivery of a shRNA sequence analogous to miR-4319/miR-125-5p induces apoptosis in NSCLC cells by arresting G2/M phase 期刊论文 Xu Xuebo;Lai Yueyang;Zhou Wenzhao;Hua Zichun
37 Chimeric Antigen Receptor T-cell (CAR T) Therapy for Hematologic and Solid Malignancies: Efficacy and Safety-A Systematic Review with Meta-Analysis 期刊论文 Yu Wen-Liang;Hua Zi-Chun
38 Metformin Synergistically Enhanced the Antitumor Activity of Celecoxib in Human Non-Small Cell Lung Cancer Cells 期刊论文 Cao Nini;Lu Yanyan;Liu Jia;Cai Fangfang;Xu Huangru;Chen Jia;Zhang Xiangyu;Hua Zi-Chun;Zhuang Hongqin
39 FADD敲除增强A549细胞对依托泊苷的敏感性 期刊论文 郭婉霜;宋琬晨;田静;陈露;詹明杰;郑伟娟;华子春
40 一种肿瘤坏死因子相关凋亡配体融合蛋白及其制法和用途 奖励 华子春
41 用于凋亡细胞识别和标记的融合蛋白及其制备方法和应用 专利 华子春
42 Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response 期刊论文 Jiang Weiwei;Jin Guanghui;Cai Fangfang;Chen Xiao;Cao Nini;Zhang Xiangyu;Liu Jia;Chen Fei;Wang Feng;Dong Wei;Zhuang Hongqin;Hua Zi-Chun
43 Attenuated Salmonella VNP20009 mutant (htrA) is a promising candidate for bacteria-mediated tumour therapy in hosts with TNFR1 deficiency 期刊论文 Xu W.;Zhou T.;Zhou J.;Qiang Z.;Zhang J.;Hua Z.
44 Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8 alpha alpha plus TCR gamma delta plus T Cells 期刊论文 Zhang Xuerui;Huo Lina;Song Lulu;Hu Zhaoqing;Wang Xinran;Han Yuheng;Wang Ying;Xu Peipei;Zhang Jing;Hua Zi-Chun
45 IR820 covalently linked with self-assembled polypeptide for photothermal therapy applications in cancer 期刊论文 Huang Kaizong;Gao Mengyue;Fan Lin;Lai Yueyang;Fan Hongwei;Hua Zichun
46 Clinical Efficacy of Infliximab in Patients With Crohn Disease in Different Locations of Disease Pathology: A Meta-Analysis 期刊论文 华子春
47 温度、pH值和H_2O_2对减毒沙门氏菌VNP20009的生长及生物膜形成的影响 期刊论文 李静;包斐斐;李家璜;华子春
48 Annexin A4-EGFP融合蛋白的表达纯化及其凋亡检测能力初探 期刊论文 刘婧;王杰;华子春
49 一种含肿瘤坏死因子相关凋亡诱导配体的融合蛋白和其制备方法及由该蛋白自组装的纳米粒 专利 华子春
50 Annexin V variant and its preparation and application 专利 华子春
51 Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake 期刊论文 Chen Xiao;Zhang Jianbin;Yuan Lixia;Lay Yifei;Wong Yin Kwan;Lim Teck Kwang;Ong Chye Sun;Lin Qingsong;Wang Jigang;Hua Zichun
52 一种重组人内皮抑素融合蛋白及其制备方法和应用 专利 华子春
53 六种蛋白质与生物纳米磁珠的吸附性能研究 期刊论文 王萌慧;高瑛;李家璜;华子春
54 一种磷脂酰丝氨酸在制备治疗炎症性肠病药物中的应用 专利 华子春
55 Identification of Peptide Antagonists to Thioredoxin Glutathione Reductase of Schistosoma japonicum 期刊论文 Song Li-Jun;Li Jia-Huang;Yin Xu-Ren;Zhang Wei;Jin Yi;Gao Hong;Wang Jie;Yu Chuan-Xin;Hua Zi-Chun
56 一种肿瘤坏死因子相关凋亡配体融合蛋白及其制法和用途 专利 华子春
57 Advances in Biopharmaceutical Technology in China 2nd Ed 专著 华子春
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