氨基酸调控机体能量和糖脂代谢的作用与机制
31830044
2018
C1107.营养与代谢生理学
郭非凡
重点项目
教授
复旦大学
297万元
氨基酸;脂代谢;营养感应;能量稳态;糖代谢
2019-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Intestinal activating transcription factor 4 regulates stress-related behavioral alterations via paraventricular thalamus in male mice | 期刊论文 | Feixiang Yuan;Ziheng Zhou;Shangming Wu;Fuxin Jiao;Liang Chen;Leilei Fang;Hanrui Yin;Xiaoming Hu;Xiaoxue Jiang;Kan Liu;Fei Xiao;Haizhou Jiang;Shanghai Chen;Zhanju Liu;Yousheng Shu;Feifan Guo |
| 2 | Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination | 期刊论文 | Yuguo Niu;Haizhou Jiang;Hanrui Yin;Fenfen Wang;Ronggui Hu;Xiaoming Hu;Bo Peng;Yousheng Shu;Zhigang Li;Shanghai Chen;Feifan Guo |
| 3 | Amino Acid Sensing in Metabolic Homeostasis and Health | 期刊论文 | Xiaoming Hu;Feifan Guo |
| 4 | 上海市领军人才 | 奖励 | 郭非凡 |
| 5 | Hepatic cytokine‐inducible SH2‐containing protein (CISH) regulates gluconeogenesis via cAMP‐responsive element binding protein (CREB) | 期刊论文 | Fei Xiao;Jiali Deng;Fuxin Jiao;Xiaoming Hu;Haizhou Jiang;Feixiang Yuan;Shanghai Chen;Yuguo Niu;Xiaoxue Jiang;Feifan Guo |
| 6 | 国务院政府特殊津贴 | 奖励 | 郭非凡 |
| 7 | Activation of GCN2 in macrophages promotes white adipose tissue browning and lipolysis under leucine deprivation | 期刊论文 | Wang Fenfen;Xiao Fei;Du Linjuan;Niu Yuguo;Yin Hanrui;Zhou Ziheng;Jiang Xiaoxue;Jiang Haizhou;Yuan Feixiang;Liu Kan;Chen Shanghai;Duan Shengzhong;Guo Feifan |
| 8 | 上海市巾帼创新奖 | 奖励 | 郭非凡 |
| 9 | Activation of GCN2/ATF4 Signals in Amygdalar PKC-δ Neurons Promotes WAT Browning Under Leucine Deprivation | 期刊论文 | Feixiang Yuan;Haizhou Jiang;Hanrui Yin;Xiaoxue Jiang;Fuxin Jiao;Shanghai Chen;Hao Ying;Yan Chen;Qiwei Zhai;Feifan Guo |
| 10 | Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling | 期刊论文 | Feixiang Yuan;Hanrui Yin;Yalan Deng;Fuxin Jiao;Haizhou Jiang;Yuguo Niu;Shanghai Chen;Hao Ying;Qiwei Zhai;Yan Chen;Feifan Guo |
| 11 | Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice | 期刊论文 | Fei Xiao;Haizhou Jiang;Zi Li;Xiaoxue Jiang;Shanghai Chen;Yuguo Niu;Hanrui Yin;Yousheng Shu;Bo Peng;Wei Lu;Xiaoying Li;Zhigang Li;Shujue Lan;Xiaoyan Xu;Feifan Guo |
| 12 | A fifty percent leucine-restricted diet reduces fat mass and improves glucose regulation | 期刊论文 | Zhou Ziheng;Yin Hanrui;Guo Yajie;Fang Yuanyuan;Yuan Feixiang;Chen Shanghai;Guo Feifan |
| 13 | Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons | 期刊论文 | Feixiang Yuan;Shangming Wu;Ziheng Zhou;Fuxin Jiao;Hanrui Yin;Yuguo Niu;Haizhou Jiang;Shanghai Chen;Feifan Guo |
| 14 | Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression | 期刊论文 | Hanrui Yin;Feixiang Yuan;Fuxin Jiao;Yuguo Niu;Xiaoxue Jiang;Jiali Deng;Yajie Guo;Shanghai Chen;Qiwei Zhai;Cheng Hu;Yiming Li;Feifan Guo |
| 15 | Amino acid sensor GCN2 promotes SARS-CoV-2 receptor ACE2 expression in response to amino acid deprivation | 期刊论文 | Xiaoming Hu;Yuguo Niu;Peixiang Luo;Fei Xiao;Feixiang Yuan;Hanrui Yin;Shanghai Chen;Feifan Guo |
| 16 | 缓解抑郁的方法、组合物及应用 | 专利 | 郭非凡;原飞翔;周子亨;胡小明 |
| 17 | ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides | 期刊论文 | Xiaoming Hu;Jiali Deng;Tianming Yu;Shanghai Chen;Yadong Ge;Ziheng Zhou;Yajie Guo;Hao Ying;Qiwei Zhai;Yan Chen;Feixiang Yuan;Yuguo Niu;Weigang Shu;Huimin Chen;Caiyun Ma;Zhanju Liu;Feifan Guo |
| 18 | Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility | 期刊论文 | Fuxin Jiao;Xiaoming Hu;Hanrui Yin;Feixiang Yuan;Ziheng Zhou;Wei Wu;Shanghai Chen;Zhanju Liu;Feifan Guo |
| 19 | SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2 | 期刊论文 | Xiaoxue Jiang;Kan liu;Haizhou Jiang;Hanrui Yin;En-duo Wang;Hong Cheng;Feixiang Yuan;Fei xiao;Fenfen wang;Wei Lu;Bo Peng;Yousheng Shu;Xiaoying Li;Shanghai Chen;Feifan Guo |
| 20 | 改善代谢性疾病的肠道益生菌及其应用 | 专利 | 郭非凡;胡小明;牛雨果 |
| 21 | Intestinal epithelial cell-specific deletion of cytokine-inducible SH2- containing protein alleviates experimental colitis in ageing mice | 期刊论文 | Xiaoming Hu;Fuxin Jiao;Jiali Deng;Ziheng Zhou;Shanghai Chen;Changqin Liu;Zhanju Liu;Feifan Guo |
| 22 | Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening | 期刊论文 | Jiali Deng;Yajie Guo;Feixiang Yuan;Shanghai Chen;Hanrui Yin;Xiaoxue Jiang;Fuxin Jiao;Fenfen Wang;Hongbin Ji;Guohong Hu;Hao Ying;Yan Chen;Qiwei Zhai;Fei Xiao;Feifan Guo |
| 23 | Impacts of essential amino acids on energy balance | 期刊论文 | Fei Xiao;Feifan Guo |
| 24 | Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals | 期刊论文 | Fei Xiao;Yajie Guo;Jiali Deng;Feixiang Yuan;Yuzhong Xiao;Lijian Hui;Yu Li;Zhimin Hu;Yuncai Zhou;Kai Li;Xiao Han;Qichen Fang;Weiping Jia;Yan Chen;Hao Ying;Qiwei Zhai;Shanghai Chen;Feifan Guo |
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