Caprin-2在Wnt信号通路中的作用机制与生物学功能
31530094
2015
C0702.细胞信号转导
李林
重点项目
研究员
中国科学院分子细胞科学卓越创新中心
268万元
基因敲除小鼠;Wnt信号通路;Caprin-2
2016-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 建立克服基因功能冗余的全基因组功能缺失筛选方法 | 专利 | 李林;毛丽;吴殿青;李亦学;王振 |
| 2 | VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer | 期刊论文 | Shi Jiao;Chuanchuan Li;Qian Hao;Haofei Miao;Lei Zhang;Lin Li;Zhaocai Zhou |
| 3 | A Genome-wide Loss-of-function Screening Method for Minimizing False-negatives caused by Functional Redundancy | 期刊论文 | Li Mao;Chenglin Liu;Zhen Wang;Xiaofeng Niu;Liang Xue;Zhilei Zhou;Zhenying Cai;Meng Yu;Yixue Li;Dianqing Wu;Lin Li |
| 4 | 15-Oxospiramilactone derivatives, preparation methods and uses thereof | 专利 | Xiaojiang Hao;Chen Yan;Haiyang Liu;Lin Li;Xiaoli He;Quan Chen |
| 5 | Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity | 期刊论文 | Xiaoli He;Wenjuan Zhang;Chen Yan;Fen Nie;Chen Li;Xiaofen Liu;Cong Fei;Shengdi Li;Xiaomin Song;Yingying Jia;Rong Zeng;Dianqing Wu;Weijun Pan;Xiaojiang Hao;Lin Li |
| 6 | Mitochondria-targeted platinum (II) complexes: dual inhibitory activities on tumor cell proliferation and migration/invasion via intracellular trafficking of β-catenin | 期刊论文 | Jingling Li;Xiaoli He;Yeling Zou;Dandan Chen;Liecheng Yang;Jiaming Rao;Huabing Chen;Michael C. W. Chan;Lin Li;Zhengqing Guo and;Leshuai W. Zhang;Chunying Chen |
| 7 | 15-氧代绣线菊内酯的作用靶点CARF的发现及其在经典Wnt信号通路中的功能 | 专利 | 李林;何小丽;郝小江;晏晨 |
| 8 | The plant sesquiterpene lactone parthenolide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF | 期刊论文 | Xiaoliang Zhu;Chunmao Yuan;Chenyang Tian;Chen Li;Fen Nie;Xiaomin Song;Rong Zeng;Dianqing Wu;Xiaojiang Hao;Lin Li |
| 9 | Phenanthridine derivatives, preparation methods and uses thereof | 专利 | Xiaojiang Hao;Duozhi Chen;Lin Li;Zonggen Peng;Jiandong Jiang;Yingtong Di;Junlin Yin;Sheng Wang;Jieyun Cai |
| 10 | Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors | 期刊论文 | Jichang Han;Meng Yu;Yiqin Bai;Jianzhong Yu;Fei Jin;Chen Li;Rong Zeng;Jinghong Peng;Ao Li;Xiaomin Song;Hao Li;Dianqing Wu;Lin Li |
| 11 | CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway | 期刊论文 | Wenhao Cui;Xiaoli He;Xiaohong Zhai;Huan Zhang;Yuanwei Zhang;Fei Jin;Xiaomin Song;Dianqing Wu;Qinghua Shi;Lin Li |
| 12 | DKK2 imparts tumor immunity evasion through β-catenin independent suppression of cytotoxic immune cell activation | 期刊论文 | Qian Xiao;Jibo Wu;Wei-Jia Wang;Shiyang Chen;Yingxia Zheng;Xiaoqing Yu;Katrina Meeth;Mahnaz Sahraei;Alfred L. M. Bothwell;Lieping Chen;Marcus Bosenberg;Jianfeng Chen;Veronika Sexl;Le Sun;Lin Li;Wenwen Tang;Dianqing Wu |
| 13 | 一种可用作Wnt信号通路激活剂的化合物及其制备与应用 | 专利 | 李林;汪胜;郝小江;潘巍峻;尹俊林;聂芬;陈铎之 |
| 14 | Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation | 期刊论文 | Xin Wang;Yingying Jia;Cong Fei;Xiaomin Song;Lin Li |
| 15 | CARF在经典Wnt信号通路中的功能 | 专利 | 李林;何小丽;郝小江;晏晨 |
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