KLF5转录因子作为基底型三阴性乳腺癌治疗靶点的研究
U1602221
2016
H1803.肿瘤细胞命运
陈策实
联合基金项目
研究员
中国科学院昆明动物研究所
197万元
肿瘤干细胞;KLF5转录因子;二甲双胍;乳腺癌;超级增强子
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | The role of E3 ubiquitin ligase HECTD3 in cancer and beyond | 期刊论文 | Qiuyun Jiang;Fubing Li;Zhuo Cheng;Yanjie Kong;Ceshi Chen |
| 2 | SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR | 期刊论文 | Zhao Lina;Qiu Ting;Jiang Dewei;Xu Haibo;Zou Li;Yang Qin;Chen Ceshi;Jiao Baowei |
| 3 | Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy | 期刊论文 | Zhang Rou;Liu Wenjin;Sun Jian;Kong Yanjie;Chen Ceshi |
| 4 | Krupple-like factor 5 is essential for mammary gland development and tumorigenesis. | 期刊论文 | Liu Rong;Shi Peiguo;Zhou Zhongmei;Zhang Hailin;Li Wei;Zhang Hong;Chen Ceshi |
| 5 | Pyrrolo [3,4-b]-quinolin-9-amine compound FZU-0038-056 suppresses triple-negative breast cancer partially through inhibiting the expression of Bcl-2 | 期刊论文 | Wang Danping;Nie Zhi;Jiang Xiaoyan;Ye Jinxiang;Wei Zhimin;Cheng Dating;Wang Chenyang;Wu Yingying;Liu Rong;Chen Haijun;Chen Ceshi;Wang Chunyan |
| 6 | A new Schiff base copper(II) complex induces cancer cell growth inhibition and apoptosis by multiple mechanisms | 期刊论文 | Bao Rui-Dan;Song Xue-Qing;Kong Yan-jie;Li Fang-Fang;Liao Wen-Hui;Zhou Jie;Zhang Ji-hong;Zhao Qi-Hua;Xu Jing-Yuan;Chen Ce-shi;Xie Ming-Jin |
| 7 | Synthesis and structure-activity relationship studies of MI-2 analogues as MALT1 inhibitors. | 期刊论文 | Wu Guolin;Wang Haixia;Zhou Wenhui;Zeng Bihua;Mo Wenhui;Zhu Kejie;Liu Rong;Zhou Jia;Chen Ceshi;Chen Haijun |
| 8 | Mechanisms of CDK4/6 Inhibitor Resistance in Luminal Breast Cancer | 期刊论文 | Li Zhen;Zou Wei;Zhang Ji;Zhang Yunjiao;Xu Qi;Li Siyuan;Chen Ceshi |
| 9 | HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. | 期刊论文 | Li Fubing;Li Yang;Liang Huichun;Xu Tao;Kong Yanjie;Huang Maobo;Xiao Ji;Chen Xi;Xia Houjun;Wu Yingying;Zhou Zhongmei;Guo Xiaomin;Hu Chunmiao;Yang Chuanyu;Cheng Xu;Chen Ceshi;Qi Xiaopeng |
| 10 | CUL7 promotes cancer cell survival through promoting Caspase-8 ubiquitination | 期刊论文 | Kong Yanjie;Wang Zehua;Zhou Zhongmei;Mao Xiaoyun;Chen Ceshi |
| 11 | Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis | 期刊论文 | Liu Rong;Chen Haijun;Zhao Ping;Chen Chuan-Huizi;Liang Huichun;Yang Chuanyu;Zhou Zhongmei;Zhi Xu;Liu Suling;Chen Ceshi |
| 12 | Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Kruppel-like factor 5 transcription by Sp1. | 期刊论文 | Liu Rong;Zhi Xu;Zhou Zhongmei;Zhang Hailin;Yang Runxiang;Zou Tianning;Chen Ceshi |
| 13 | Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2 | 期刊论文 | Zhou Wenhui;Fang Huan;Wu Qiuju;Wang Xinye;Liu Rong;Li Fubin;Xiao Ji;Yuan Lin;Zhou Zhongmei;Ma Junying;Wang Lulu;Zhao Weiwei;You Hua;Ju Jianhua;Feng Jing;Chen Ceshi |
| 14 | miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells. | 期刊论文 | Liang Huichun;Ge Fei;Xu Yuhui;Xiao Ji;Zhou Zhongmei;Liu Rong;Chen Ceshi |
| 15 | Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway | 期刊论文 | Dong Chao;Chen Yin;Ma Jing;Yang Runxiang;Li Hongjian;Liu Rong;You Dingyun;Luo Chunxiang;Li Heng;Yang Siyuan;Ke Kunbin;Lin Marie Chia-mi;Chen Ceshi |
| 16 | EZH2 induces the expression of miR-1301 as a negative feedback control mechanism in triple negative breast cancer. | 期刊论文 | Wu Qiuju;Chen Zekun;Zhang Guihua;Zhou Wenhui;Peng You;Liu Rong;Chen Ceshi;Feng Jing |
| 17 | Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression | 期刊论文 | He Lingli;Yuan Liang;Sun Yang;Wang Pingyang;Zhang Hailin;Feng Xue;Wang Zuoyun;Zhang Wenxiang;Yang Chuanyu;Zeng Yi Arial;Zhao Yun;Chen Ceshi;Zhang Lei |
| 18 | 米非司酮衍生物及其用途 | 专利 | 陈策实;陈海军;刘蓉;林雨琦;郑政;赵平;杨传雨 |
| 19 | TNF-alpha increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-kappa B pathway | 期刊论文 | Liu Wenjing;Lu Xiaoqing;Shi Peiguo;Yang Guangxi;Zhou Zhongmei;Li Wei;Mao Xiaoyun;Jiang Dewei;Chen Ceshi |
| 20 | Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation | 期刊论文 | Shi Peiguo;Liu Wenjing;Tala;Wang Haixia;Li Fubing;Zhang Hailin;Wu Yingying;Kong Yanjie;Zhou Zhongmei;Wang Chunyan;Chen Wenlin;Liu Rong;Chen Ceshi |
| 21 | Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers | 期刊论文 | Chen Chuan Huizi;Yang Nong;Zhang Yongchang;Ding Jiancheng;Zhang Wenjuan;Liu Rong;Liu Wen;Chen Ceshi |
| 22 | The antipsychotic agent flupentixol is a new PI3K inhibitor and potential anticancer drug for lung cancer | 期刊论文 | Dong Chao;Chen Yin;Li Hongjian;Yang Yi;Zhang Hongtao;Ke Kunbin;Shi Xi Nan;Liu Xu;Li Ling;Ma Jing;Kung Hsiang Fu;Chen Ceshi;Lin Marie Chia mi |
| 23 | CC chemokine receptor 7 promotes triple-negative breast cancer growth and metastasis. | 期刊论文 | Wu Jiao;Li Lu;Liu Jianing;Wang Yang;Wang Zehua;Wang Yangdan;Liu Wenjing;Zhou Zhongmei;Chen Ceshi;Liu Rong;Yang Runxiang |
| 24 | Tree shrew (Tupaia belangeri) as a novel laboratory disease animal model | 期刊论文 | Xiao Ji;Liu Rong;Chen Ce-Shi |
| 25 | Hypoxia induces miR-153 through the IRE1alpha-XBP1 pathway to fine tune the HIF1alpha/VEGFA axis in breast cancer angiogenesis. | 期刊论文 | Liang Huichun;Xiao Ji;Zhou Zhongmei;Wu Jiao;Ge Fei;Li Zongcheng;Zhang Hailin;Sun Jian;Li Fubing;Liu Rong;Chen Ceshi |
| 26 | Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer | 期刊论文 | Yuqi Lin;Rong Liu;Ping Zhao;Jinxiang Ye;Zheng Zheng;Jingan Huang;Yingying Zhang;Yu Gao;Haiying Chen;Suling Liu;Jia Zhou;Ceshi Chen;Haijun Chen |
| 27 | Breast cancer animal models and applications | 期刊论文 | Zeng Li;Li Wei;Chen Ce-Shi |
| 28 | The roles of TNFAIP2 in cancers and infectious diseases. | 期刊论文 | Jia Lin;Shi Yundong;Wen Yi;Li Wei;Feng Jing;Chen Ceshi |
| 29 | USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5 | 期刊论文 | Yingying Wu;Junying Qin;Fubing Li;Chuanyu Yang;Zhen Li;Zhongmei Zhou;Hailin Zhang;Yunxi Li;Xinye Wang;Rong Liu;Qian Tao;Wenlin Chen;Ceshi Chen |
| 30 | HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer | 期刊论文 | Fang Huan;Du Guangshi;Wu Qiuju;Liu Rong;Chen Ceshi;Feng Jing |
查看更多信息请先登录或注册
