艾滋病功能性治愈猕猴模型创建及其病毒潜伏机制研究

81471620
2014
H1108.免疫缺陷性疾病
郑永唐
面上项目
研究员
中国科学院昆明动物研究所
145万元
SIV;动物模型;艾滋病;病毒潜伏;功能性治愈
2015-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Identification of the major histocompatibility complex class-II DM and DO alleles in a cohort of northern pig-tailed macaques (Macaca leonina) 期刊论文 Lian XD;Zhang XH;Dai ZX;Zheng YT
2 Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239 期刊论文 Zhang LT;Tian RR;Zheng HY;Pang GQ;Tuo XY;Xia HJ;Xia XS;Pang W;Zheng YT
3 Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque 期刊论文 Zhu JW;Mu D;Liu FL;Luo MT;Luo RH;Zheng YT
4 非人灵长类动物: 免疫学基础研究到临床应用的桥梁. 期刊论文 郑宏毅;郑永唐
5 Northern pig-tailed macaques (Macaca leonina) maintain superior CD4+ T cell homeostasis during SIVmac239 infection 期刊论文 Zhang MX;Zheng HY;Jiang J;Song JH;Chen M;Xiao Y;Song TZ;Tian RR;Pang W;Zheng YT
6 Synthesis and study of anti-HIV-1 RT activity of 5-benzoyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one derivatives 期刊论文 Chander Subhash;Tang Cheng-Run;Al-Maqtari Helmi Mohammed;Jamalis Joazaizulfazli;Penta Ashok;Ben Hadda Taibi;Sirat Hasnah Mohd;Zheng Yong-Tang;Sankaranarayanan Murugesan
7 alpha3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells. 期刊论文 Zhang Xi-He;Lian Xiao-Dong;Dai Zheng-Xi;Zheng Hong-Yi;Chen Xin;Zheng Yong-Tang
8 HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo 期刊论文 Pang W;Zhang GH;Jiang J;Zheng HY;Zhang LT;Zhang XL;Song JH;Zhang MX;Zhu JW;Lei AH;Tian RR;Liu XM;Zhang L;Gao G;Su L;Zheng YT
9 Cloning, sequencing, and polymorphism analysis of novel MHC class I alleles in northern pig-tailed macaques (Macaca leonina) 期刊论文 Lian XD;Zhang XH;Dai ZX;Zheng YT
10 VSVG/HIV-1_(NL4-3)Luc假病毒筛选抗HIV-1药物的条件优化及应用 期刊论文 王萍;陈欢;罗荣华;卿晨;张高红;郑永唐
11 Burmese injecting drug users in Yunnan play a pivotal role in the cross-border transmission of HIV-1 in the China-Myanmar border region 期刊论文 Chen X;Zhou YH;Ye M;Wang Y;Duo L;Pang W;Zhang C;Zheng YT
12 性激素对天然免疫的调节改变女性生殖道HIV-1易感性 期刊论文 张明旭;郑永唐
13 CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS 期刊论文 Tian RR;Zhang MX;Zhang LT;Zhang P;Ma JP;Liu M;Devenport M;Zheng P;Zhang XL;Lian XD;Ye M;Zheng HY;Pang W;Zhang GH;Zhang LG;Liu Y;Zheng YT
14 Parasites may exit immune-compromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239 期刊论文 Song TZ;Zhang MX;Xia YJ;Xiao Y;Pang W;Zheng YT
15 艾滋病诊断、治疗和预防产品的评价关键技术建立与推广应用 奖励 王佑春;郑永唐;黄维金;杨柳萌;许四宏;王睿睿;聂建辉;刘强;罗荣华;宋爱京
16 Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae 期刊论文 Chen H;Zhang R;Luo RH;Yang LM;Wang RR;Hao XJ;Zheng YT
17 葡萄糖代谢异常导致SIVmac239感染北平顶猴急性期体重变化. 期刊论文 张翰丹;宋天章;杨柳萌;郑永唐
18 High immune activation and abnormal expression of cytokine contribute to death of SHIV89.6-infected Chinese rhesus macaque 期刊论文 Tian RR;Zhang MX;Zhang LT;Zhang XL;Zheng HY;Zhu L;Pang W;Zhang GH;Zheng YT
19 Characterization of classical major histocompatibility complex (MHC) class II gene in northern pig-tailed macaques (Macaca leonina) 期刊论文 Lian XD;Zhang XH;Dai ZX;Zheng YT
20 免疫衰老在艾滋病发病中的作用及治疗策略研究进展 期刊论文 郑宏毅;郑永唐
21 Lipopolysaccharide increases immune activation and alters T cell homeostasis in SHIVB’WHU chronically infected Chinese rhesus macaque 期刊论文 Zhang GH;Wu RD;Zheng HY;Zhang XL;Zhang MX;Tian RR;Liu GM;Pang W;Zheng YT
22 Molecular cloning and anti-HIV-1 activities of APOBEC3s from northern pig-tailed macaques (Macaca leonina). 期刊论文 Zhang XL;Song JH;Pang W;Zheng YT
23 艾滋病功能性治愈策略研究进展 期刊论文 李婷;郑永唐;田仁荣
24 HIV感染与细胞焦亡 期刊论文 陈敏;郑永唐
25 Predict disease progression from T cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection 期刊论文 Zhang MX;Zheng HY;Jiang J;Song JH;Chen M;Xiao Y;Lian XD;Song TZ;Tian RR;Pang W;Zheng YT
26 艾滋病猕猴模型的肠道病理学研究进展 期刊论文 张琳萄;夏雪山;郑永唐
27 Accelerated disease progression and robust host response in aged Chinese rhesus macaques infected with SIVmac239 associate with enhanced immunosenescence 期刊论文 Zheng HY;Zhang MX;Chen M;Jiang J;Song JH;Lian XD;Tian RR;Zhang XL;Zhang LT;Pang W;Zhang GH;Zheng YT
28 Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition 期刊论文 Mu D;Zhu JW;Liu FL;Zheng HY;Zheng YT
29 Host restriction factors APOBEC3G/3F and other interferon-related gene expressions affect early HIV-1 infection in Northern pig-tailed macaque (Macaca leonina) 期刊论文 Pang W;Song JH;Lu Y;Zhang XL;Zheng HY;Jiang J;Zheng YT
30 氯喹/羟氯喹在艾滋病治疗中的应用研究进展 期刊论文 向思颖;张高红;郑永唐
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