ALDH2调控NAMPT-NAD+-SIRT3信号通路改善视网膜感光细胞老化的作用及机制研究
82001484
2020
H1902.衰老相关疾病
龙盘
青年科学基金项目
主治医师
中国人民解放军西部战区总医院
24万元
烟酰胺腺嘌呤二核苷酸;沉默信息调节因子2相关酶类3;感光细胞老化;乙醛脱氢酶2;烟酰胺磷酸核糖转移酶
2021-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Protective effect of aldehyde dehydrogenase 2 against rat corneal dysfunction caused by streptozotocin-induced type I diabetes | 期刊论文 | Long Pan;He Mengshan;Zhang Xi;Luo Tao;Shen Yang;Liu Heng;Jiang Wei;Han Fei;Hu Yonghe |
| 2 | ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum. | 期刊论文 | Long Pan;He Mengshan;Yan Weiming;Chen Wei;Wei Dongyu;Wang Siwang;Zhang Zuoming;Ge Wei;Chen Tao |
| 3 | ALDH2/SIRT1 Contributes to Type 1 and Type 2 Diabetes-Induced Retinopathy through Depressing Oxidative Stress. | 期刊论文 | He Mengshan;Long Pan;Chen Tao;Li Kaifeng;Wei Dongyu;Zhang Yufei;Wang Wenjun;Hu Yonghe;Ding Yi;Wen Aidong |
| 4 | Proteomic and Morphological Profiling of Mice Ocular Tissue During High-altitude Acclimatization Process: An Animal Study at Lhasa | 期刊论文 | Jun Hou;Dezhi Zheng;Xudong Wen;Wenjing Xiao;Fei Han;Hongmei Lang;Shiqiang Xiong;Wei Jiang;Yonghe Hu;Mengshan He;Pan Long |
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