新型芳亚胺基噻唑类化合物KJ1371多途径增效多黏菌素B抗鲍曼不动杆菌作用机制的研究

81773616
2017
H3403.微生物药物
邵雷
面上项目
研究员
上海医药工业研究院有限公司
62万元
芳亚胺基噻唑类化合物;增效剂;多黏菌素B;鲍曼不动杆菌;抗生素
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 Efficient synthesis of an antiviral drug intermediate using an enhanced short-chain dehydrogenase in an aqueous-organic solvent system 期刊论文 Wu Kai;Zheng Kun;Xiong Liangbin;Yang Zhijun;Jiang Zhiteng;Meng Xiangguo;Shao Lei
2 Enhance 4′-epidaunorubicin production of engineering Streptomyces coeruleorubidus strains via both knockout of daunorubicin-consuming enzymes dnrX and dnrU, and multiple copies of rate-limiting enzyme aveBIV 期刊论文 Shao Lei;Chen Ji-Ye;Zi Jia-Chen;Chen Dai-Jie
3 New azaphilones, phomopsones A-C with biological activities from an endophytic fungus Phomopsis sp. CGMCC No.5416 期刊论文 Zhi-Jun Yang;Yi-Fan Zhang;Kai Wu;Yi-Xin Xu;Xiang-Guo Meng;Zhi-Teng Jiang;Mei Ge;Lei Shao
4 Synthesis of dehydroepiandrosterone by co-immobilization of keto reductase and glucose dehydrogenase 期刊论文 Zhang Junliang;Pu Tian;Xu Ying;Huang Junhai;Chen Daijie;Shao Lei
5 Gut Microbiota Approach-A New Strategy to Treat Parkinson's Disease. 期刊论文 Liu Jing;Xu Fei;Nie Zhiyan;Shao Lei
6 Efficient synthesis of bepotastine and cloperastine intermediates using engineered alcohol dehydrogenase with a hydrophobic pocket 期刊论文 Wu Kai;Yan Jinrong;Wang Xiaojing;Yin Xinai;Shi Guixiang;Yang Lei;Li Fangling;Huang Junhai;Shao Lei
7 Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876 期刊论文 Yang Zhijun;Shao Lei;Wang Meixia;Rao Min;Ge Mei;Xu Yixin
8 Extending Viability of Bifidobacterium longum in Chitosan-Coated Alginate Microcapsules Using Emulsification and Internal Gelation Encapsulation Technology 期刊论文 Ji Rui;Wu Jiahui;Zhang Junliang;Wang Tao;Zhang Xudong;Shao Lei;Chen Daijie;Wang Jian
9 一种抗菌增效剂及其制法和用途 专利 陈代杰;徐晓勇;邵雷;李忠;董晓景;侯爽;张骏梁;王蓉
10 Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of stereocontrol element 期刊论文 Wu Kai;Yang Zhijun;Meng Xiangguo;Chen Rong;Huang Jiankun;Shao Lei
11 Efficient synthesis of an antiviral drug intermediate using overexpressed short-chain dehydrogenase and cross-linked enzyme aggregates stabilization 期刊论文 Kai Wu;Xiaozhi Hu;Zhijun Yang;Junhai Huang;Xiaojing Wang;Lei Shao
12 Biocatalytic preparation of a key intermediate of antifungal drugs using an alcohol dehydrogenase with high organic tolerance 期刊论文 Jinrong Yan;Xiaojing Wanyg;Fangling Li;Lei Yang;Guixiang Shi;Weihang Sun;Lei Shao;Junhai Huang;Kai Wu
13 一种新型芳亚胺基噻唑类化合物、其制备方法和用途 专利 徐晓勇;陈代杰;李忠;邵雷;侯爽;董晓景;王蓉;张骏梁
14 Three novel chromanones with biological activities from the endophytic fungus Phomopsis CGMCC No. 5416 期刊论文 Zhijun Yang;Wu Kai;Xu Yixin;Xia Xing;Wang Xuejun;Ge Mei;Shao Lei
15 Efficient bioconversion of daptomycin to its nucleus by heterologous expression of deacylase genes in Streptomyces 期刊论文 Wang Xiaojing;Liu Jing;Zhang Hanzhi;Wu Kai;Yang Zhijun;Ning Ruonan;Huang Junhai;Shao Lei
16 Preparation and characterization of selenium enriched-Bifidobacterium longum DD98, and its repairing effects on antibiotic-induced intestinal dysbacteriosis in mice 期刊论文 Zhu Hui;Zhou Yan;Qi Yan;Ji Rui;Zhang Junliang;Qian Zhixiang;Wu Chunzhen;Tan Jun;Shao Lei;Chen Daijie
17 一种噻唑类化合物用作抗菌增效剂的用途 专利 陈代杰;徐晓勇;邵雷;李忠;董晓景;侯爽;张骏梁;王蓉
查看更多信息请先登录或注册

相关项目

趋势报告

经验分享