【U1304205】基于阿尔茨海默病药物分子的多肽类靶向载体的设计与合成研究国家自然基金项目

基于阿尔茨海默病药物分子的多肽类靶向载体的设计与合成研究

项目批准号： U1304205

批准年份： 2013

学科分类： B0702.生物分子的化学生物学

项目负责人：夏宁

资助类别：联合基金项目

负责人职称：副教授

依托单位：安阳师范学院

资助金额： 30万元

关键词：多肽;阿尔茨海默病;β-淀粉样肽;药物载体;金属配合物

起止时间： 2014-01-01到2016-12-31

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序号	标题	类型	作者
1	A graphene oxide-based fluorescent scheme for the determination of the activity of the beta-site amyloid precursor protein (BACE1) and its inhibitors	期刊论文	Lin Liu\|Ning Xia\|Jie Yu\|
2	4-Mercaptophenylboronic acid-induced in situ formation of silver nanoparticle aggregates as labels on an electrode surface	期刊论文	Yuanqiang Hao\|Yuanqiang Hao\|Xiaojin Wang\|Xiaojin Wang\|
3	A Graphene Oxide-Based Fluorescent Platform for Probing of Phosphatase Activity	期刊论文	Ting Sun\|Ning Xia\|Lin Liu\|
4	Design of electrochemical biosensors with peptide probes as the receptorsof targets and the inducers of gold nanoparticles assembly onelectrode surface	期刊论文	Yun Xing\|Yun Xing\|Lin Liu\|Lin Liu\|
5	Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing	期刊论文	Xiaojin Wang\|Ning Xia\|Lin Liu\|
6	Electrochemical detection of amyloid-beta oligomer with the signal amplification of alkaline phosphatase plus electrochemical-chemical-chemical redox cycling	期刊论文	Nanbing Huang\|Shuo Guo\|Sujuan Li\|Shenglu Zhang\|
7	Visual and fluorescent assays for selective detection of beta-amyloid oligomers based on the inner filter effect of gold nanoparticles on the fluorescence of CdTe quantum dots	期刊论文	Nanbing Huang\|Mengsha Jiang\|Jiebing Zhang\|Lin Liu\|
8	Peptide aptamer-based biosensor for the detection of human chorionic gonadotropin by converting silver nanoparticles-based colorimetric assay into sensitive electrochemical analysis	期刊论文	Huizhu Ren\|Huizhu Ren\|Lin Liu\|Lin Liu\|
9	A graphene oxide-based fluorescent platform for selective detection of amyloid-beta oligomers	期刊论文	Jiebin Zhang\|Wenhui Mao\|Yangyang Wu\|Xingxing Ge\|
10	Electrochemical Detection of Amyloid-beta Oligomers Based on the Signal Amplification of a Network of Silver Nanoparticles	期刊论文	Binbin Zhou\|Yangyang Wu\|Wenhui Mao\|Lin Liu\|
11	Aptasensor for visual and fluorometric determination of lysozyme based on the inner filter effect of gold nanoparticles on CdTe quantum dots	期刊论文	Ning Xia\|Tingting Li\|Yanhua Bai\|Xiaolan Chen\|
12	Nanocomposites of Graphene with Ferrocene or Hemin: Preparation and Application in Electrochemical Sensing	期刊论文	Ning Xia\|Lin Liu\|Zhifang Sun\|Binbin Zhou\|
13	A simple and label-free electrochemical method for detection of beta-site amyloid precursor protein cleaving enzyme and screening of its inhibitor	期刊论文	Youjuan Zhang\|Pengpeng Guan\|Yuanqiang Hao\|Lin Liu\|
14	An electrochemical aptasensor for sensitive and selective detection of dopamine based on signal amplification of electrochemical-chemical redox cycling	期刊论文	Ning Xia\|Jing-Jing Meng\|Bin-Bin Zhou\|Su-Juan Li\|
15	Amplified voltammetric detection of glycoproteins using 4-mercaptophenylboronic acid/biotin-modified multifunctional gold nanoparticles as labels	期刊论文	Hui Zhang\|Ruili Liu\|Huijing Liu\|Ning Xia\|
16	Ascorbic acid-triggered electrochemical-chemical-chemical redox cycling for design of enzyme-amplified electrochemical biosensors on self-assembled monolayer-covered gold electrodes	期刊论文	Ruijuan Wu\|Huiping Liu\|Su-Juan Li\|Yuanqiang Hao\|
17	Design of electrochemical biosensors with peptide probes as the receptorsof targets and the inducers of gold nanoparticles assembly onelectrode surface	期刊论文	Yun Xing\|Yun Xing\|Lin Liu\|Lin Liu\|
18	4-Mercaptophenylboronic acid-induced in situ formation of silver nanoparticle aggregates as labels on an electrode surface	期刊论文	Yuanqiang Hao\|Yuanqiang Hao\|Xiaojin Wang\|Xiaojin Wang\|
19	Electrochemical-chemical-chemical redox cycling triggered by thiocholine and hydroquinone with ferrocenecarboxylic acid as the redox mediator	期刊论文	Yanping Gao\|Huiping Liu\|Jimin Du\|Ning Xia\|
20	A signal-on electrochemical strategy for protease detection based on the formation of ATCUN-Cu(II)	期刊论文	Jiaying Du\|Gaihong Zhu\|Weimin Du\|Lin Liu\|
21	Metallothioneins and Synthetic Metal Chelators as Potential Therapeutic Agents for Removal of Aberrant Metal Ions from Metal-A beta Species	期刊论文	Ning Xia\|Lin Liu\|
22	Biosensors for the Determination of Amyloid-Beta Peptides and their Aggregates with Application to Alzheimer's Disease	期刊论文	Yun Xing\|Ning Xia\|
23	Ferrocene-phenylalanine hydrogels for immobilization of acetylcholinesterase and detection of chlorpyrifos	期刊论文	Yaping Jing\|Sujuan Li\|Lin Liu\|Ge Qu\|
24	Nanomaterials-Based Sensing Strategies for Electrochemical Detection of MicroRNAs	期刊论文	Ning Xia\|Liping Zhang\|
25	Nanomaterials-Based Optical Techniques for the Detection of Acetylcholinesterase and Pesticides	期刊论文	Ning Xia\|Qinglong Wang\|Lin Liu\|
26	An electrochemical microRNAs biosensor with the signal amplification of alkaline phosphatase and electrochemical-chemical-chemical redox cycling	期刊论文	Youjuan Zhang\|Xin Wei\|Yaping Huang\|Lin Liu\|
27	Peptide aptamer-based biosensor for the detection of human chorionic gonadotropin by converting silver nanoparticles-based colorimetric assay into sensitive electrochemical analysis	期刊论文	Huizhu Ren\|Huizhu Ren\|Lin Liu\|Lin Liu\|
28	A Graphene Oxide-Based Fluorescent Method for the Detection of Human Chorionic Gonadotropin	期刊论文	Ning Xia\|Xin Wang\|Lin Liu\|

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