创新霉素的生物合成机制研究
81872780
2018
H3403.微生物药物
洪斌
面上项目
研究员
中国医学科学院医药生物技术研究所
57万元
创新霉素;合成生物学;生物合成机制
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Cytochrome P450 Monooxygenase for Catalyzing C-42 Hydroxylation of the Glycine-Derived Fragment in Hangtaimycin Biosynthesis | 期刊论文 | Li Xingxing;Fu Jie;Li Yihua;Liu Jiachang;Gao Rongmei;Shi Yuanyuan;Li Yihong;Sun Hongmin;Wang Lifei;Li Yuhuan;Jiang Bingya;Wu Linzhuan;Hong Bin |
| 2 | The Cytochrome P450 Catalyzing C-S Bond Formation in S-Heterocyclization of Chuangxinmycin Biosynthesis | 期刊论文 | Shi Yuanyuan;Jiang Zhibo;Hu Xiaowen;Hu Xiaomin;Gu Renjie;Jiang Bingya;Zuo Lijie;Li Xingxing;Sun Hongmin;Zhang Cong;Wang Lifei;Wu Linzhuan;Hong Bin |
| 3 | Exploring novel herbicidin analogues by transcriptional regulator overexpression and MS/MS molecular networking. | 期刊论文 | Shi Yuanyuan;Gu Renjie;Li Yihong;Wang Xinwei;Ren Weicong;Li Xingxing;Wang Lifei;Xie Yunying;Hong Bin |
| 4 | Multi-omics-guided discovery of omicsynins produced by Streptomyces sp. 1647: pseudo-tetrapeptides active against influenza a viruses and coronavirus HCoV-229E | 期刊论文 | Sun Hongmin;Li Xingxing;Chen Minghua;Zhong Ming;Li Yihua;Wang Kun;Du Yu;Zhen Xin;Gao Rongmei;Wu Yexiang;Shi Yuanyuan;Yu Liyan;Che Yongsheng;Li Yuhuan;Jiang Jian-Dong;Hong Bin;Si Shuyi |
| 5 | Production of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027 | 期刊论文 | Xingxing Li;Weicong Ren;Yihong Li;Yuanyuan Shi;Hongmin Sun;Lifei Wang;Linzhuan Wu;Yunying Xie;Yu Du;Zhibo Jiang;Bin Hong |
| 6 | Iterative Methylation Leads to 3-Methylchuangxinmycin Production in Actinoplanes tsinanensis CPCC 200056 | 期刊论文 | Xiaomin Hu;Yuanyuan Shi;Bingya Jiang;Jie Fu;Xingxing Li;Shufen Li;Guizhi Sun;Weicong Ren;Xinxin Hu;Xuefu You;Zhiyong Liu;Xingli Han;Tianyu Zhang;Bin Hong;Linzhuan Wu |
| 7 | The human gut microbiome - a new and exciting avenue in cardiovascular drug discovery | 期刊论文 | Yu Du;Xingxing Li;Chunyan Su;Li Wang;Jiandong Jiang;Bin Hong |
| 8 | Rescrutiny of the sansanmycin biosynthetic gene cluster leads to the discovery of a novel sansanmycin analogue with more potency against Mycobacterium tuberculosis | 期刊论文 | Yuanyuan Shi;Xinwei Wang;Ning He;Yunying Xie;Bin Hong |
| 9 | 一组生物合成创新霉素或开环创新霉素的基因簇 | 专利 | 洪斌;侍媛媛;武临专;蒋建东;江志波;李星星;左利杰;雷璇 |
| 10 | 创新霉素在抑制消化道病原菌中的应用 | 专利 | 洪斌;李星星;侍媛媛;武临专;胡晓敏 |
| 11 | Comparative genomics and transcriptomics analyses provide insights into the high yield and regulatory mechanism of Norvancomycin biosynthesis in Amycolatopsis orientalis NCPC 2-48 | 期刊论文 | Xingxing Li;Cong Zhang;Zhao Ying;Xuan Lei;Zhibo Jiang;Xuexia Zhang;Zhihui Zheng;Shuyi Si;Lifei Wang;Bin Hong |
| 12 | 基因组发掘策略指导铁载体类化合物的 发现 | 期刊论文 | 江志波;李星星;任卫聪;侍媛媛;高荣梅;李玉环;武临专;洪斌 |
| 13 | 创新霉素及其衍生物在抑制结核分枝杆菌中的应用 | 专利 | 洪斌;武临专;张天宇;侍媛媛;刘志永;胡晓敏;任卫聪;布哈里·优素福;田茜溶;李星星 |
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