新型苯甲酰胺类化合物16-4通过抑制CYP7A1缓解胆汁淤积性肝病的效果和机制研究
81673497
2016
H3508.消化与呼吸系统药物药理
何红伟
面上项目
研究员
中国医学科学院医药生物技术研究所
54万元
胆汁淤积性肝病;CYP7A1;转录调控;胆汁淤积;核受体
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells | 期刊论文 | Yudong Pang;Yunyang Bao;Sheng Tang;Tianyun Niu;Zhihao Guo;Hongwei He;Yinghong Li;Danqing Song |
| 2 | 盐酸石蒜碱通过Akt/Smad通路抑制肝星状细胞增殖与活化 | 期刊论文 | 张镱萱;葛茂旭;张娜;牛伟晓;鲍云洋;赵午莉;刘虹;邵荣光;何红伟 |
| 3 | 2-苯磺酰胺基苯甲酰胺类化合物在肝损伤保护和肝纤维化防治中的应用 | 专利 | 邵荣光;王玉成;李娜仁;蔡仕英;何红伟;王菊仙;赵双双;葛茂旭;任金凤 |
| 4 | 苯磺酰胺基苯甲酰胺类化合物在制备治疗非酒精性脂肪性肝病药物中的应用 | 专利 | 邵荣光;何红伟;葛茂旭;王菊仙;王玉成;蔡仕英;任金凤;赵午莉;刘虹;赵跃;张镱萱;牛伟晓 |
| 5 | D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress | 期刊论文 | Zhao Shuang shuang;Li Na ren;Zhao Wu li;Liu Hong;Ge Mao xu;Zhang Yi xuan;Zhao Long yin;You Xue fu;He Hongwei;Shao Rong guang |
| 6 | Advances in understanding the regulatory mechanism of cholesterol 7 alpha-hydroxylase | 期刊论文 | Ge Mao xu;Shao Rong guang;He Hong wei |
| 7 | 2-苯磺酰胺基苯甲酰胺类化合物在制备治疗肝癌药物中的应用 | 专利 | 何红伟;王玉成;葛茂旭;王菊仙;邵荣光;张娜;李娜仁;刘志峰 |
| 8 | 整合素的基因表达调控 | 期刊论文 | 张镱萱;邵荣光;何红伟 |
| 9 | Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation | 期刊论文 | Ge Mao-xu;Liu Hong-tao;Zhang Na;Niu Wei-xiao;Lu Zhen-ning;Bao Yun-yang;Huang Rui;Yu Dong-ke;Shao Rong-guang;He Hong-wei |
| 10 | 木香烃内酯在制备抗肝纤维化药物中的应用 | 专利 | 何红伟;邵荣光;葛茂旭;张娜;牛伟晓;鲍云洋;张镱萱;赵午莉;刘虹 |
| 11 | 12N-取代胺甲酰基苦参碱衍生物及其制备方法和用途 | 专利 | 宋丹青;李迎红;何红伟;牛天宇;唐胜;鲍云洋;庞雨东 |
| 12 | 4-甲基-5,6-二氢吡喃-2酮在制备抗肝纤维化和抗肝癌药物中的应用 | 专利 | 何红伟;陈明华;牛伟晓;张娜;葛茂旭;路振宁;鲍云洋 |
| 13 | D手性肌醇在制备抗肝纤维化药物中的应用 | 专利 | 何红伟;邵荣光;李娜仁;赵双双;金中甲;赵龙吟;赵午莉;刘虹;葛茂旭;张镱萱 |
| 14 | A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters | 期刊论文 | Ge Mao xu;Niu Wei xiao;Ren Jin feng;Cai Shi ying;Yu Dong ke;Liu Hong tao;Zhang Na;Zhang Yi xuan;Wang Yu cheng;Shao Rong guang;Wang Ju xian;He Hong wei |
| 15 | The anti-hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes-associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy | 期刊论文 | Ge Maoxu;Liu Hong;Zhang Yixuan;Li Naren;Zhao Shuangshuang;Zhao Wuli;Zhen Yongzhan;Yu Jianzhong;He Hongwei;Shao Rong-guang |
| 16 | Pepstatin Pr通过YAP-TGFβ-Smad通路发挥体外抗肝纤维化作用 | 期刊论文 | 牛伟晓;陈明华;张娜;葛茂旭;鲍云洋;司书毅;邵荣光;何红伟 |
| 17 | Novel cytisine derivatives exert anti-liver fibrosis effect via PI3K/Akt/Smad pathway | 期刊论文 | Tang Sheng;Li Yinghong;Bao Yunyang;Dai Zhiting;Niu Tianyu;Wang Kun;He Hongwei;Song Danqing |
| 18 | A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin alpha v expression | 期刊论文 | Zhang Na;Zhao Shuang-shuang;Zhang Yi-xuan;Wang Yu-cheng;Shao Rong-guang;Wang Ju-xian;He Hong-wei |
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