小分子配体与碱性成纤维细胞生长因子(bGFG)的结合及抑制作用

90913007
2009
B0702.生物分子的化学生物学
任劲松
重大研究计划
研究员
中国科学院长春应用化学研究所
50万元
血管新生;结合;碱性成纤维细胞生长因子;抑制剂
2010-01-01到2012-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 DNA/Ligand/lon-Based Ensemble for Fluorescence Turn on Detection of Cysteine and Histidine with Tunable Dynamic Range 期刊论文 F. Pu, Z. Huang, J. Ren, X. Qu|F. Pu, Z. Huang, J. Ren, X. Qu|
2 Design of proton-fueled tweezers for controlled, multi-function DNA-based molecular device, 期刊论文 G. Song, M. Chen, C. Chen, J. Ren, X. Qu|G. Song, M. Chen, C. Chen, J. Ren, X. Qu|
3 pH-responsive NIR enhanced drug release from gold nanocages possesses high potency against cancer cells 期刊论文 P. Shi, K. Qu, J. Wang, M. Li, J. Ren, X. Qu| P. Shi, K. Qu, J. Wang, M. Li, J. Ren, X. Qu|
4 A Label-Free, Quadruplex-Based Functional Molecular Beacon (LFG4-MB) for Fluorescence Turn-On Detection of DNA and Nuclease, 期刊论文 D. Hu, Z. Huang, F. Pu, J. Ren, X. Qu,| D. Hu, Z. Huang, F. Pu, J. Ren, X. Qu,|
5 Site-Specific DNA-Programmed Growth of Fluorescent and Functional Silver Nanoclusters, 期刊论文 Z. Huang, F. Pu, D. Hu, C. Wang, J. Ren, X. Qu|Z. Huang, F. Pu, D. Hu, C. Wang, J. Ren, X. Qu|
6 Versatile Logic Devices Based on Programmable DNA-Regulated Silver-Nanocluster Signal Transducers 期刊论文 Z. Huang, Y. Tao, F. Pu, J. Ren, X. Qu|Z. Huang, Y. Tao, F. Pu, J. Ren, X. Qu|
7 Polyaniline nanofibers: synthesis, characterization and application to the direct electron transfer of glucose oxidase, 期刊论文 M. Zhao, X. Wu and C. Cai,| M. Zhao, X. Wu and C. Cai,|
8 Identification of polyoxometalates as inhibitors of basic fibroblast growth factor 期刊论文 F. Pu, E. Wang, H. Jiang and J. Ren| F. Pu, E. Wang, H. Jiang and J. Ren|
9 Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery 期刊论文 Z. Chen, Z. Li, Y. Lin, M. Yin, J. Ren,X. Qu| Z. Chen, Z. Li, Y. Lin, M. Yin, J. Ren,X. Qu|
10 Controllable synthesis of PbSe nanocubes in aqueous phase using a quasi-biosystem, 期刊论文 R. Cui, Y. Gu, Z. Tian and D. Pang|R. Cui, Y. Gu, Z. Tian and D. Pang|
11 Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles 期刊论文 X. Yang, X. Liu, Z. Liu, F. Pu, J. Ren, X. Qu|
12 A multicomponent recognition and separation system established via fluorescent, magnetic, dualencoded multifunctional bioprobes, 期刊论文 J. Hu, M. Xie, C. Wen, Z. Zhang, D. Pang|J. Hu, M. Xie, C. Wen, Z. Zhang, D. Pang|
13 Aptamer Biosensor Based on Fluorescence Resonance Energy Transfer from Upconverting Phosphors to Carbon Nanoparticles for Thrombin Detection in Human Plasma 期刊论文 Y. Wang, L. Bao, Z. Liu, and D. Pang,|Y. Wang, L. Bao, Z. Liu, and D. Pang,|
14 Artificial DNA Nano-Spring Powered by Protons, 期刊论文 C. Wang, Z. Huang, Y. Lin, J. Ren, X. Qu| C. Wang, Z. Huang, Y. Lin, J. Ren, X. Qu|
15 pH-controlled reversible drug binding and release using a cytosine-rich hairpin DNA 期刊论文 C. Xu, C. Zhao, J. Ren, X. Qu| C. Xu, C. Zhao, J. Ren, X. Qu|
16 Sensitive, selective and label-free protein detection using a smart polymeric transducer and aptamer/ligand system, 期刊论文 F. Pu, Z. Huang, D. Hu, J. Ren, X, Qu| F. Pu, Z. Huang, D. Hu, J. Ren, X, Qu|
17 Combination of Graphene Oxide and Thiol-Activated DNA Metallization for Sensitive Fluorescence Turn-On Detection of Cysteine and Their Use for Logic Gate Operations, 期刊论文 Y. Lin, Y. Tao, F. Pu, J. Ren, X. Qu,| Y. Lin, Y. Tao, F. Pu, J. Ren, X. Qu,|
18 Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli-Responsive Vehicles for Intracellular Drug Delivery, 期刊论文 C. Chen, J. Geng, F. Pu, X. Yang, J. Ren, X.Qu| C. Chen, J. Geng, F. Pu, X. Yang, J. Ren, X.Qu|
19 Triplex inducer-directed self-assembly of single-walled carbon nanotubes: a triplex DNA-based approach for controlled manipulation of nanostructures, 期刊论文 C. Zhao, K. Qu, C. Xu, J. Ren, X. Qu,| C. Zhao, K. Qu, C. Xu, J. Ren, X. Qu,|
20 Proton-Fueled DNA-Duplex-Based Stimuli-Responsive Reversible Assembly of Single-Walled Carbon Nanotubes, 期刊论文 C. Zhao, K. Qu, J. Ren, X. Qu,|C. Zhao, K. Qu, J. Ren, X. Qu,|
21 Pd@Pt core-shell nanostructures with controllable composition synthesized by a microwave method and their enhanced electrocatalytic activity toward oxygen reduction and methanol oxidation, 期刊论文 H. Zhang, Y. Yin, Y. Hu, C. Li, P. Wu, C. Cai| H. Zhang, Y. Yin, Y. Hu, C. Li, P. Wu, C. Cai|
22 pH-responsive DNA assembly regulated through A-motif, 期刊论文 C. Wang, Y. Tao, F. Pu, J. Ren, X. Qu| C. Wang, Y. Tao, F. Pu, J. Ren, X. Qu|
23 Evaluation of the Bioconjugation Efficiency of Different Quantum Dots as Probes for Immunostaining Tumor-Marker Proteins, 期刊论文 H. Xu, C. Chen, J. Peng, D. Pang,|H. Xu, C. Chen, J. Peng, D. Pang,|
24 Miyoshi, N. Sugimoto and X. Qu, Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes, 期刊论文 X. Wang, C. Wang, J. Ren, X, Qu|X. Wang, C. Wang, J. Ren, X, Qu|
25 Electrochemical detection of hepatitis C virus based on site-specific DNA cleavage of BamHI endonuclease, 期刊论文 S. Lin, Y. Hu, J. Jin, H. Zhang and C. Cai| S. Lin, Y. Hu, J. Jin, H. Zhang and C. Cai|
26 Photosensitizer-incorporated G-quadruplex DNA-functionalized magnetoflu orescent nanoparticles for targeted magnetic resonance/fluorescence multimodal imaging and subsequent photodynamic therapy of cancer, 期刊论文 4) M. Yin, M. Li, Z., Liu, J. Ren, X. Qu,|
27 Electrochemical measurement of the flux of hydrogen peroxide releasing from RAW 264.7 macrophage cells based on enzyme–attapulgite clay nanohybrids, 期刊论文 P. Wu, Z. Cai, J. Chen, H. Zhang, C. Cai,| P. Wu, Z. Cai, J. Chen, H. Zhang, C. Cai,|
28 Silica nanoparticles based label-free aptamer hybridization for ATP detection using hoechst33258 as the signal reporter 期刊论文 L. Cai, Z. Chen, X. Dong, H. Tang and D. Pang| L. Cai, Z. Chen, X. Dong, H. Tang and D. Pang|
29 A label-free fluorescent turn-on enzymatic amplification assay for DNA detection using ligand-responsive G-quadruplex formation, 期刊论文 C. Zhao, L. Wu, J. Ren, X. Qu,|C. Zhao, L. Wu, J. Ren, X. Qu,|
30 DNA-based logic gates operating as a biomolecular security device, 期刊论文 F. Pu, Z. Liu, X. Yang, J. Ren, X. Qu| F. Pu, Z. Liu, X. Yang, J. Ren, X. Qu|
31 i-Motif Quadruplex DNA-Based Biosensor for Distinguishing Single- and Multiwalled Carbon Nanotubes, 期刊论文 Y. Peng, X. Wang, Y. Xiao, J. Ren, X. Qu|Y. Peng, X. Wang, Y. Xiao, J. Ren, X. Qu|
32 Multivalued Logic Gates Based on DNA 期刊论文 F. Pu, J. Ren, X. Yang, X. Qu| F. Pu, J. Ren, X. Yang, X. Qu|
33 Chiral Metallo-Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions, 期刊论文 C. Zhao, J. Geng, L. Feng, J. Ren, X. Qu|C. Zhao, J. Geng, L. Feng, J. Ren, X. Qu|
34 A reversible DNA-silver nanoclusters-based molecular fluorescence switch and its use for logic gate operation, 期刊论文 Z. Huang, J. Ren, X. Qu| Z. Huang, J. Ren, X. Qu|
35 Contrasting enantioselective DNA preference: chiral helical macrocyclic lanthanide complex binding to DNA, 期刊论文 C. Zhao, J. Ren, J. Gregoliński, X. Qu|C. Zhao, J. Ren, J. Gregoliński, X. Qu|
36 Direct electrochemistry of glucose oxidase assembled on graphene and application to glucose detection, 期刊论文 P. Wu, Q. Shao, Y. Hu, J. Jin, Y. Yin, C. Cai| P. Wu, Q. Shao, Y. Hu, J. Jin, Y. Yin, C. Cai|
37 Electrochemical approach for the specific detection of hepatitis C virus based on site–specific DNA cleavage of BamHI endonuclease, 期刊论文 S. Liu, Q. Wang, D. Chen, J. Jin, C. Cai| S. Liu, Q. Wang, D. Chen, J. Jin, C. Cai|
38 Core/Shell Structured Noble Metal (Alloy)/Cadmium Selenide Nanocrystals, 期刊论文 Z. Tian, Z. Zhang, P. Jiang, D. Pang| Z. Tian, Z. Zhang, P. Jiang, D. Pang|
39 Speeding Up a Bidirectional DNA Walking Device 期刊论文 C. Wang, Y. Tao, G. Song, J. Ren, X. Qu| C. Wang, Y. Tao, G. Song, J. Ren, X. Qu|
40 Graphene–gold nanostructure composites fabricated by electrodeposition and their electrocatalytic activity toward the oxygen reduction and glucose oxidation, 期刊论文 Y. Hu, J. Jin, P. Wu, H. Zhang and C. Cai,| Y. Hu, J. Jin, P. Wu, H. Zhang and C. Cai,|
41 Enhancing the electrochemical reduction of hydrogen peroxide based on nitrogen-doped graphene for measurement of its releasing process from living cells, 期刊论文 P. Wu, Z. W. Cai, Y. Gao, H. Zhang, C. Cai,| P. Wu, Z. W. Cai, Y. Gao, H. Zhang, C. Cai,|
42 Enzymatic Manipulation of DNA-Modified Gold Nanoparticles for Screening G-Quadruplex Ligands and Evaluating Selectivities, 期刊论文 C. Chen, C. Zhao, X. Yang, J. Ren, X. Qu|C. Chen, C. Zhao, X. Yang, J. Ren, X. Qu|
43 Ultrasensitive and selective electrochemical identification of hepatitis C virus genotype 1b based on specific endonuclease combined with gold nanoparticles signal amplification, 期刊论文 S. Liu, P. Wu, W. Li, H. Zhang, C. Cai,| S. Liu, P. Wu, W. Li, H. Zhang, C. Cai,|
44 DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity, 期刊论文 H.. Yu, C. Zhao, Y. Chen, F. Fu, J. Ren, X. Qu| H.. Yu, C. Zhao, Y. Chen, F. Fu, J. Ren, X. Qu|
45 A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells, 期刊论文 L. Feng, Y. Chen, J. Ren, X. Qu|L. Feng, Y. Chen, J. Ren, X. Qu|
46 A Simple, Universal Colorimetric Assay for Endonuclease/Methyltransferase Activity and Inhibition Based on an Enzyme-Responsive Nanoparticle System, 期刊论文 G. Song, C. Chen, J. Ren, X. Qu,| G. Song, C. Chen, J. Ren, X. Qu,|
47 Electrochemical and spectroscopic studies on the conformational structure of hemoglobin assembled on gold nanoparticles, 期刊论文 Q. Shao, P. Wu, P. Gu, X. Q. Xu, H. Zhang, C. Cai|Q. Shao, P. Wu, P. Gu, X. Q. Xu, H. Zhang, C. Cai|
48 Logic gates and pH sensing devices based on a supramolecular telomere DNA/conjugated polymer system, 期刊论文 F. Pu, C. Y. Wang, D. Hu, J.Ren, X. Qu| F. Pu, C. Y. Wang, D. Hu, J.Ren, X. Qu|
49 Quantum Dot-Ferrichrome Bioprobes for Recognition of Pseudomonas fluorescens, 期刊论文 S. Wu, Z. Zhang, X. Wang, D. Pang| S. Wu, Z. Zhang, X. Wang, D. Pang|
50 Polyoxometalates as Inhibitors of the Aggregation of Amyloid beta Peptides Associated with Alzheimer's Disease 期刊论文 J. Geng, M. Li, J. Ren, E. Wang and X. Qu| J. Geng, M. Li, J. Ren, E. Wang and X. Qu|
51 Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease 期刊论文 M. Li, X. Yang, J. Ren, K. Qu and X. Qu| M. Li, X. Yang, J. Ren, K. Qu and X. Qu|
52 Recognition and regulation of unique nucleic acid structures by small molecules, 期刊论文 G. Song and J. Ren| G. Song and J. Ren|
53 Covalent conjugation of avidin with dye-doped silica nanopaticles and preparation of high density avidin nanoparticles as photostable bioprobes, 期刊论文 Z. Chen, L. Cai, X. Dong, H. Tang and D. Pang| Z. Chen, L. Cai, X. Dong, H. Tang and D. Pang|
54 uantum dots-based double-color imaging of HER2 positive breast cancer invasion, 期刊论文 X. Liu, C. Peng, C. Chen,D. Pang and Y. Li,|X. Liu, C. Peng, C. Chen,D. Pang and Y. Li,|
55 Kinetics-Controlled Formation of Gold Clusters Using a Quasi-Biological System, 期刊论文 M. Zhang, R. Cui, Z. Tian, Z. Zhang , D. Pang| M. Zhang, R. Cui, Z. Tian, Z. Zhang , D. Pang|
56 Aptamer-Capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Delivery and Imaging. 期刊论文 Z. Li, Z. Liu, M. Yin,J. Ren, X. Qu,|Z. Li, Z. Liu, M. Yin,J. Ren, X. Qu,|
57 Fluorescent-Magnetic-Biotargeting Multifunctional Nanobioprobes for Detecting and Isolating Multiple Types of Tumor Cells, 期刊论文 E. Song, J. Hu, C. Wen,Y. Shi and D. Pang, Z.|E. Song, J. Hu, C. Wen,Y. Shi and D. Pang, Z.|
58 Using Thermally Regenerable Cerium Oxide Nanoparticles in Biocomputing to Perform Label-free, Resettable, and Colorimetric Logic Operations 期刊论文 Y. Lin, C. Xu, J. Ren,X. Qu|Y. Lin, C. Xu, J. Ren,X. Qu|
59 A Universal, Label-Free, and Sensitive Optical Enzyme-Sensing System for Nuclease and Methyltransferase Activity Based on Light Scattering of Carbon Nanotubes, 期刊论文 C. Zhao, K. Qu, Y. Song, J. Ren, X. Qu,| C. Zhao, K. Qu, Y. Song, J. Ren, X. Qu,|
60 Intermediate-dominated controllable biomimetic synthesis of gold nanoparticles in a quasi-biological system, 期刊论文 R. Cui, M.. Zhang, Z. Tian, D. Pang|R. Cui, M.. Zhang, Z. Tian, D. Pang|
61 An enzyme-responsive nanocontainer as an intelligent signal-amplification platform for a multiple proteases assay 期刊论文 X. Yang, F. Pu, C. Chen, J. Ren and X. Qu|X. Yang, F. Pu, C. Chen, J. Ren and X. Qu|
62 A gold nanoparticle-based strategy for label-free and colorimetric screening of DNA triplex binders, 期刊论文 C. Chen, G. Song, X. Yang, J. Ren, X. Qu|C. Chen, G. Song, X. Yang, J. Ren, X. Qu|
63 Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers, 期刊论文 C. Chen, F. Pu, Z. Huang, Z. Liu, J. Ren, X. Q| C. Chen, F. Pu, Z. Huang, Z. Liu, J. Ren, X. Q|
64 DNA-templated ensemble for label-free and real-time fluorescence turn-on detection of enzymatic/oxidative cleavage of single-stranded DNA, 期刊论文 X. Yang, F. Pu, J. Ren, X. Qu,| X. Yang, F. Pu, J. Ren, X. Qu,|
65 A Quadruplex-Based, Label-Free, and Real-Time Fluorescence Assay for RNase H Activity and Inhibition, 期刊论文 D. Hu, F. Pu, Z. Huang, J. Ren, X. Qu,| D. Hu, F. Pu, Z. Huang, J. Ren, X. Qu,|
66 Metal-mediated fabrication of new functional G-quartet-based supramolecular nanostructure and potential application as controlled drug release system, 期刊论文 D. Hu, J. Ren, X. Qu,|D. Hu, J. Ren, X. Qu,|
67 Facile in situ fabrication of graphene-upconversion hybrid materials with amplified electrogenerated chemiluminescence, 期刊论文 M. Yin, L. Wu, Z. Li, J. Ren, X. Qu| M. Yin, L. Wu, Z. Li, J. Ren, X. Qu|
68 Robust and Highly Sensitive Fluorescence Approach for Point-of-Care Virus Detection Based on Immunomagnetic Separation, 期刊论文 W. Zhao, W. Zhang, H. Wang and D. Pang| W. Zhao, W. Zhang, H. Wang and D. Pang|
69 Carbon nanodots as fluorescence probes for rapid, sensitive, and label-free detection of Hg2+ and biothiols in complex matrices, 期刊论文 L. Zhou, Y. Lin, Z. Huang, J. Ren and X. Qu| L. Zhou, Y. Lin, Z. Huang, J. Ren and X. Qu|
70 Electrochemical DNA three-way junction based sensor for distinguishing chiral metallo-supramolecular complexes, 期刊论文 L. Feng, C. Zhao, Y. Xiao, J. Ren, X.Qu|L. Feng, C. Zhao, Y. Xiao, J. Ren, X.Qu|
71 Abruna and D. Pang, Color-tunable fluorescent-magnetic core/shell multifunctional nanocrystals, 期刊论文 Z. Tian, Z. Zhang, J. Gao, D. Pang|Z. Tian, Z. Zhang, J. Gao, D. Pang|
72 A Reusable DNA Single-Walled Carbon-Nanotube-Based Fluorescent Sensor for Highly Sensitive and Selective Detection of Ag+ and Cysteine in Aqueous Solutions, 期刊论文 C. Zhao, K. Qu,Y. Song, C. Xu, J. Ren, X. Qu| C. Zhao, K. Qu,Y. Song, C. Xu, J. Ren, X. Qu|
73 Silver metallization engineered conformational switch of G-quadruplex for fluorescence turn-on detection of biothiols, 期刊论文 Z. Chen, Y. Lin, C. Zhao, J. Ren, X. Qu| Z. Chen, Y. Lin, C. Zhao, J. Ren, X. Qu|
74 Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles 期刊论文 X. Yang, X. Liu, Z. Liu, F. Pu, J. Ren, X. Qu|
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