抑制肿瘤细胞以端粒酶为信号转导途径的作用机理研究

90813001
2008
B0702.生物分子的化学生物学
曲晓刚
重大研究计划
研究员
中国科学院长春应用化学研究所
50万元
生物热力学;构象转化;端粒DNA;端粒酶;配体-DNA识别
2009-01-01到2011-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Molecular-Glue-Triggered DNA Assembly To Form a Robust and Photoresponsive Nano-Network 期刊论文
2 Stabilization of unstable CGC+ triplex DNA by single-walled carbon nanotubes under physiological conditions 期刊论文
3 A simple, universal colorimetric assay for endonuclease/methyltransferase activity and inhibition based on an enzyme-responsive nanoparticle system 期刊论文
4 Selective and quantitative cancer cell detection using target-directed functionalized graphene and its synergetic peroxidase-like activity 期刊论文
5 Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli-Responsive Vehicles for Intracellular Drug Delivery 期刊论文
6 Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers 期刊论文
7 (被选为本期扉页) Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes 期刊论文
8 Artificial DNA nano-spring powered by protons 期刊论文
9 i-Motif Quadruplex DNA-Based Biosensor for Distinguishing Single- and Multiwalled Carbon Nanotubes 期刊论文
10 Sensitive, selective and label-free protein detection using a smart polymeric transducer and aptamer/ligand system 期刊论文
11 Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA 期刊论文
12 Alzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form 期刊论文
13 Rapid and ultra-sensitive detection of AMP using a fluorescent and magnetic nano-silica sandwich complex 期刊论文
14 A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells 期刊论文
15 Visual and quantitative detection of copper ions using magnetic silica nanoparticles clicked on multiwalled carbon nanotubes 期刊论文
16 DNA-Templated Silver Nanoparticles as a Platform for Highly Sensitive and Selective Fluorescence Turn-On Detection of Dopamine 期刊论文
17 Triplex inducer-directed self-assembly of single-walled carbon nanotubes: a triplex DNA-based approach for controlled manipulation of nanostructures 期刊论文
18 A Reusable DNA Single-Walled Carbon Nanotube Based Fluorescent Sensor for Highly Sensitive and Selective Detection of Ag+ and Cysteine in Aqueous Solutions 期刊论文
19 A DNA nanomachine induced by single-walled carbon nanotubes on gold surface 期刊论文
20 Proton-Fueled DNA Duplex-Based Stimuli-Responsive Reversible Assembly of Single-Walled Carbon Nanotubes 期刊论文
21 Modulating DNA-templated silver nanoclusters for fluorescence turn-on detection of thiol compounds 期刊论文
22 Polyoxometalates as Inhibitors of the Aggregation of Amyloid ?-Peptides Associated with Alzheimer’s Disease 期刊论文
23 DNA-based logic gates operating as a biomolecular security device 期刊论文
24 Small-molecule selectively recognizes human telomeric G-quadruplex DNA and regulates its conformational switch 期刊论文
25 A stimuli responsive DNA walking device 期刊论文
26 Carbon nanodots as fluorescence probes for rapid, sensitive, and label-free detection of Hg2+ and biothiols in complex matrices 期刊论文
27 Chiral Metallo–Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions 期刊论文
28 Visualizing Human Telomerase Activity with Primer-Modified Au Nanoparticles 期刊论文
29 Combination of Graphene Oxide and Thiol-Activated DNA Metallization for Sensitive Fluorescence Turn-On Detection of Cysteine and Their Use for Logic Gate Operations 期刊论文
30 A label-free fluorescent turn-on enzymatic amplification assay for DNA detection using ligand-responsive G-quadruplex formation 期刊论文
31 pH-controlled reversible drug binding and release using a cytosine-rich hairpin DNA 期刊论文
32 Light regulation of peroxidase activity by spiropyran functionalized carbon nanotubes used for label-free colorimetric detection of lysozyme 期刊论文
33 A Quadruplex-based, Label-free and Real-time Fluorescence Assay for RNase H Activity and Inhibition 期刊论文
34 A Label-Free, Quadruplex-Based Functional Molecular Beacon (LFG4-MB) for Fluorescence Turn-On Detection of DNA and Nuclease 期刊论文
35 Enzymatic manipulation of DNA-modified gold nanoparticles for screening G-quadruplex ligands and evaluating selectivities 期刊论文
36 A Universal, Label-Free, and Sensitive Optical Enzyme-Sensing System for Nuclease and Methyltransferase Activity Based on Light Scattering of Carbon Nanotubes 期刊论文
37 Synthesis and Characterization of Red-Luminescent Graphene Oxide Functionalized with Silica-Coated Eu3+ Complex Nanoparticles 期刊论文
38 Multivalued Logic Gates Based on DNA 期刊论文
39 Detection of a Prognostic Indicator in Early-Stage Cancer Using Functionalized Graphene-Based Peptide Sensors 期刊论文
40 The use of multifunctional magnetic mesoporous core/shell heteronanostructures in a biomolecule separation system 期刊论文
41 Sensing metal ions with ion selectivity of a crown ether and fluorescence resonance energy transfer between carbon dots and graphene 期刊论文
42 Colorimetric Biosensing Using Smart Materials 期刊论文
43 Label-Free Colorimetric Detection of Single Nucleotide Polymorphism by Using Single-Walled Carbon Nanotube Intrinsic Peroxidase-Like Activity 期刊论文
44 Graphene Oxide: Intrinsic Peroxidase Catalytic Activity and Its Application to Glucose Detection 期刊论文
45 DNA-templated ensemble for label-free and real-time fluorescence turn-on detection of enzymatic/oxidative cleavage of single-stranded DNA 期刊论文
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