多组学及质谱成像技术研究人参-五味子调控微生物-肠-脑轴治疗阿尔茨海默症的作用机制

81873193
2018
H3303.中西医结合研究新技术与新方法
宋凤瑞
面上项目
研究员
中国科学院长春应用化学研究所
56万元
阿尔兹海默症;质谱成像;代谢组学;人参-五味子;肠内菌
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Investigation of plasma metabolomics and neurotransmitter dysfunction in the process of Alzheimer's disease rat induced by amyloid beta 25-35 期刊论文 Mengying Wei;Yuanyuan Liu;Zifeng Pi;Kexin Yue;Shizhe Li;Mingxin Hu;Zhiqiang Liu;Fengrui Song;Zhongying Liu
2 An integrated strategy using LC-MS/MS combined with in vivo microdialysis for the simultaneous determination of lignans of Schisandra chinensis (Turcz.) Baill. Fructus and endogenous neurotransmitters: application in pharmacokinetic and pharmacodynamic studies 期刊论文 Jun Fu;Hongxu Zhang;Shu Liu;Jiajie Wu;Yuying Zhang;Yang Gao;Fengrui Song;Yuhua Qin;Xiuli Hu;Zhongying Liu
3 Stabilities of superoxide dismutase and metal-free superoxide dismutase studied by electrospray ionization–ion mobility–mass spectrometry 期刊论文 Zhao Bing;Zhuang XiaoYu;Bian XinYu;Liu Shu;Liu Zhiqiang;Song Fengrui
4 Screening apo‐SOD1 conformation stabilizers from natural flavanones by using Native ion mobility mass spectrometry and fluorescence spectroscopy methods 期刊论文 Bing Zhao;Xinyu Bian;Xiaoyu Zhuang;Shu Liu;Zhiqiang Liu;Fengrui Song
5 Teamed boronate affinity-functionalized branched polyethyleneimine-modified magnetic nanoparticles for the selective capture of ginsenosides from rat plasma 期刊论文 Ningning Zhao;Zhiqiang Liu;Junpeng Xing;Zhong Zheng;Fengrui Song;Shu Liu
6 Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC–Q-TOF-MS 期刊论文 Mengying Wei;Yuanyuan Liu;Zifeng Pi;Shizhe Li;Mingxin Hu;Yang He;Kexin Yue;Tianshu Liu;Zhiqiang Liu;Fengrui Song;Zhongying Liu
7 Effects of aprotic solvents on the stability of metal-free superoxide dismutase probed by native electrospray ionization-ion mobility-mass spectrometry 期刊论文 Bing Zhao;Xiaoyu Zhuang;Xinyu Bian;Zifeng Pi;Shu Liu;Zhiqiang Liu;Fengrui Song
8 Trace determination and characterization of ginsenosides in rat plasma through magnetic dispersive solid-phase extraction based on core-shell polydopamine-coated magnetic nanoparticles 期刊论文 Zhao Ningning;Liu Shu;Xing Junpeng;Pi Zifeng;Song Fengrui;Liu Zhiqiang
9 Putative multiple reaction monitoring strategy for the comparative pharmacokinetics of postoral administration RensheneYuanzhi compatibility through liquid chromatographyetandem mass Spectrometry 期刊论文 Yufei Sun;Guifang Feng;Yan Zheng;Shu Liu;Yan Zhang;Zifeng Pi;Fengrui Song;Zhqiang Liu
10 Studies on the mechanism of Panax Ginseng in the treatment of deficiency of vital energy dementia rats based on urine metabolomics 期刊论文 Yu Huang;Zhiqiang Liu;Shu Liu;Fengrui Song;Yongri Jin
11 Pharmacokinetic and metabolomics approach based on UHPLC-MS to evaluate therapeutic effect of lignans from S. Chinensis in alzheimer's disease 期刊论文 Yuan Zhou;Mengying Wei;Meiling Fan;Zhongying Liu;Aimin Wang;Yuanyuan Liu;Lihui Men;Zifeng Pi;Zhiqiang Liu;Fengrui Song
12 Unfolding and aggregation of oxidized metal-deficient superoxide dismutase and isoflavone inhibition based on ion mobility mass spectrometry and ThT fluorescence assay 期刊论文 Xinyu Bian;Xiaoyu Zhuang;Zhong Zheng;Shu Liu;Zhiqiang Liu;Fengrui Song
13 Mass spectrometry-based urinary metabolomics for exploring the treatment effects of Radix ginseng-Schisandra chinensis herb pair on Alzheimer's disease in rats 期刊论文 Aimin Wang;Zifeng Pi;Shu Liu;Zhong Zheng;Zhiqiang Liu;Fengrui Song
14 An integrated platform for a high-throughput pharmacokinetic study of glycosides using a boronic acid-functionalized 96-well glass plate 期刊论文 Zhao Ningning;Gu Qianqian;Liu Zhiqiang;Song Fengrui;Pi Zifeng;Liu Shu
15 In-depth investigation of the mechanisms of Schisandra chinensis polysaccharide mitigating Alzheimer’s disease rat via gut microbiota and feces metabolomics 期刊论文 Jun Fu;Jixun Li;YUzhen SunZ;Shu Liu;Fengrui Song;Zhongying Liu
16 An integrated study on the comprehensive mechanism of schisandra chinensis polysaccharides mitigating Alzheimer's disease rats using a UPLC-Q-TOF-MS based serum and urine metabolomics strategy 期刊论文 Jun Fu;Jixun Li;Yuzhen Sun;Shu Liu;Fengrui Song;Zhongyin Liu
17 Urinary and plasmatic metabolomics strategy to explore the holistic mechanism of lignans in S. chinensis in treating Alzheimer’s disease using UPLC-Q-TOF-MS† 期刊论文 Mengying Wei;Zhongying Liu;Yuanyuan Liu;Shizhe Li;Mingxin Hu;Kexin Yue;Tianshu Liu;Yang He;Zifeng Pi;Zhiqiang Liu;Fengrui Song
18 Magnetic nanoparticles-based lactate dehydrogenase microreactor as a drug discovery tool for rapid screening inhibitors from natural products 期刊论文 Guirong Cheng;Zifeng Pi;Zhong Zheng;Shu Liu;Zhiqiang Liu;Fengrui Song
19 Pharmacodynamic and urinary metabolomics studies on the mechanism of Schisandra polysaccharide in the treatment of Alzheimer’s disease 期刊论文 Yuanyuan Liu;Zhongying Liu;Mengying Wei;Mingxin Hu;Kexin Yue;Rongbing Bi;Shan Zhai;Zifeng Pi;Fengrui Song;Zhiqiang Liu
20 Urine metabolic profiling of dementia rats with vital energy deficiency using ultra‐high‐performance liquid chromatography coupled with an orbitrap mass spectrometer 期刊论文 Yu Huang;Zhiqiang Liu;Shu Liu;Fengrui Song;Xiuli Hu;Yuhua Qin;Yongri Jin
21 Comparative pharmacokinetics of Ding‐Zhi‐Xiao‐Wan preparation and its single herbs in rats by using a putative multiple‐reaction monitoring UPLC‐MS/MS method 期刊论文 Yufei Sun;Yang He;Shuxin Liu;Hongxue Gao;Zifeng Pi;Fengrui Song;Zhiqiang Liu;Shu Liu
22 Ion‐mobility tandem mass spectrometry combined with molecular docking to research the interaction between flavonoside isomers and metal‐free superoxide dismutase 期刊论文 Xinyu Bian;Xiaoyu Zhuang;Junpeng Xing;Shu Liu;Zhiqiang Liu;Fengrui Song
23 Treatment effects of Radix ginseng-Schisandra chinensis herb pair on Alzheimer’s disease: An investigation of MS-based metabolomics investigation 期刊论文 Aimin Wang;Minjie Shi;Junpeng Xing;Shu Liu;Zhiqiang Liu;Fengrui Song
24 Studies on the cross-interaction between hIAPP and Aβ25–35 期刊论文 Bo Pang;Xiaoyu ZHuang;Shu Liu;Zhiqiang Liu;Fengrui Song
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