基于5S rRNA的黑曲霉CRISPR-Cas9高效多位点无痕基因组编辑系统研究

31700085
2017
C2102.合成生物学与生物改造技术
郑小梅
青年科学基金项目
副研究员
中国科学院天津工业生物技术研究所
25万元
CRISPR-Cas9基因组编辑系统;多位点无痕基因组编辑;合成微生物;合成生物学使能技术;黑曲霉
2018-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Systems metabolic engineering for citric acid production by Aspergillus niger in the post-genomic era 期刊论文 Tong Zhenyu;Zheng Xiaomei;Tong Yi;Shi Yong-Cheng;Sun Jibin
2 5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger 期刊论文 Zheng Xiaomei;Zheng Ping;Zhang Kun;Cairns Timothy C;Meyer Vera;Sun Jibin;Ma Yanhe
3 一种新型向导RNA表达盒及在CRISPR/Cas系统中的应用 专利 孙际宾;郑小梅;郑平;马延和
4 A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a case study using aplD in Aspergillus niger 期刊论文 Cairns Timothy C;Feurstein Claudia;Zheng Xiaomei;Zheng Ping;Sun Jibin;Meyer Vera
5 Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories 期刊论文 Cairns Timothy C;Zheng Xiaomei;Zheng Ping;Sun Jibin;Meyer Vera
6 Disruption or reduced expression of the orotidine-5 '-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger 期刊论文 Zhang Lihui;Zheng Xiaomei;Cairns Timothy C.;Zhang Zhidan;Wang Depei;Zheng Ping;Sun Jibin
7 Comprehensive optimization of the metabolomic methodology for metabolite profiling of Corynebacterium glutamicum 期刊论文 Zhang Qiongqiong;Zheng Xiaomei;Wang Yu;Yu Jiandong;Zhang Zhidan;Dele Osibanjo Taiwo;Zheng Ping;Sun Jibin;Jia Shiru;Ma Yanhe
8 有机酸产量提高的菌株及其构建方法和应用 专利 孙际宾;郑小梅;张立辉;周文娟;郑平;马延和
9 Heterologous and endogenous U6 snRNA promoters enable CRISPR/Cas9 mediated genome editing in Aspergillus niger 期刊论文 Zheng Xiaomei;Zheng Ping;Sun Jibin;Zhang Kun;Ma Yanhe
10 柠檬酸绿色制造新技术及产业化应用 奖励 佟毅;孙际宾;李义;郑小梅;岳洪浩;张德国;周勇;卢宗梅;陈博;彭超
11 面向工业生物技术的系统生物学 期刊论文 郑小梅;郑平;孙际宾
12 Comprehensive Improvement of Sample Preparation Methodologies Facilitates Dynamic Metabolomics of Aspergillus niger 期刊论文 Zheng Xiaomei;Yu Jiandong;Cairns Timothy C;Zhang Lihui;Zhang Zhidan;Zhang Qiongqiong;Zheng Ping;Sun Jibin;Ma Yanhe
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