结核分枝杆菌十异戊二烯焦磷酸合成酶功能研究及抗结核药物开发
31570130
2015
C0108.病原细菌学
刘卫东
面上项目
研究员
中国科学院天津工业生物技术研究所
62万元
十异戊二烯焦磷酸合成酶;蛋白质晶体结构;结核分枝杆菌;抗生素设计
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Structural studies reveal the molecular mechanism of PETase | 期刊论文 | Chun Chi Chen;Xu Han;Tzu Ping Ko;Weidong Liu;Rey Ting Guo |
| 2 | The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement | 期刊论文 | Chun Chi Chen;Xiangying Hu;Xueke Tang;Yunyun Yang;Tzu Ping Ko;Jian Gao;Yingying Zheng;Jian Wen Huang;Zhengsen Yu;Liping Li;Shuai Han;Ningning Cai;Yonghui Zhang;Weidong Liu;Rey Ting Guo |
| 3 | Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes | 期刊论文 | Malwal Satish R;Gao Jian;Hu Xiangying;Yang Yunyun;Liu Weidong;Huang Jian Wen;Ko Tzu Ping;Li Liping;Chen Chun Chi;O'Dowd Bing;Khade Rahul L;Zhang Yong;Zhang Yonghui;Oldfield Eric;Guo Rey Ting |
| 4 | Enhanced alpha-Zearalenol Hydrolyzing Activity of a Mycoestrogen-Detoxifying Lactonase by Structure-Based Engineering | 期刊论文 | Xu Zhongxia;Liu Weidong;Chen Chun-Chi;Li Qian;Huang Jian-Wen;Ko Tzu-Ping;Liu Guizhi;Liu Wenting;Peng Wei;Cheng Ya-Shan;Chen Yun b;Jin Jian;Li Huazhong;Zheng Yingying;Guo Rey-Ting |
| 5 | Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis | 期刊论文 | Kuo Chih Jung;Gao Jian;Huang Jian Wen;Ko Tzu Ping;Zhai Chao;Ma Lixin;Liu Weidong;Dai Longhai;Chang Yung Fu;Chen Ter Hsin;Hu Yumei;Yu Xuejing;Guo Rey Ting;Chen Chun Chi |
| 6 | Structural insight into catalytic mechanism of PET hydrolase | 期刊论文 | Xu Han;Weidong Liu;Jian-Wen Huang;Jiantao Ma;Yingying Zheng;Tzu-Ping Ko;Limin Xu;Ya-Shan Cheng;Chun-Chi Chen;Rey-Ting Guo |
| 7 | Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase. | 期刊论文 | Liu Meixia;Chen Chun-Chi;Chen Lu;Xiao Xiansha;Zheng Yingying;Huang Jian-Wen;Liu Weidong;Ko Tzu-Ping;Cheng Ya-Shan;Feng Xinxin;Oldfield Eric;Guo Rey-Ting;Ma Yanhe |
| 8 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase | 期刊论文 | Gao Jian;Ko Tzu Ping;Chen Lu;Malwal Satish R;Zhang Jianan;Hu Xiangying;Qu Fiona;Liu Weidong;Huang Jian Wen;Cheng Ya Shan;Chen Chun Chi;Yang Yunyun;Zhang Yonghui;Oldfield Eric;Guo Rey Ting |
| 9 | Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase. | 期刊论文 | Liu Meixia;Chen Chun-Chi;Chen Lu;Xiao Xiansha;Zheng Yingying;Huang Jian-Wen;Liu Weidong;Ko Tzu-Ping;Cheng Ya-Shan;Feng Xinxin;Oldfield Eric;Guo Rey-Ting;Ma Yanhe |
| 10 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase | 期刊论文 | Gao Jian;Ko Tzu Ping;Chen Lu;Malwal Satish R;Zhang Jianan;Hu Xiangying;Qu Fiona;Liu Weidong;Huang Jian Wen;Cheng Ya Shan;Chen Chun Chi;Yang Yunyun;Zhang Yonghui;Oldfield Eric;Guo Rey Ting |
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