肿瘤微环境响应聚氨基酸水凝胶化疗/免疫联合治疗系统的构建与抗肿瘤应用研究

51973218
2019
E0308.生物医用有机高分子材料
贺超良
面上项目
研究员
中国科学院长春应用化学研究所
57万元
生物医用高分子;局部缓释;联合治疗;水凝胶;环境响应
2020-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine 期刊论文 Zhen Zhang;Chaoliang He;Xuesi Chen
2 Physiologically relevant pH- and temperature-responsive polypeptide hydrogels with adhesive properties 期刊论文 Yingge Shi;Dong Li;Junfeng Ding;Chaoliang He;Xuesi Chen
3 Matrix metalloproteinase-sensitive poly(ethylene glycol)/peptide hydrogels as an interactive platform conducive to cell proliferation during 3D cell culture 期刊论文 Yan Rong;Zhen Zhang;Chaoliang He;Xuesi Chen
4 Hydrogel scaffolds with controlled postgelation modulation of structures for 3D cell culture and tissue engineering 期刊论文 Jiaxuan Yang;Yan Rong;Xuesi Chen;Chaoliang He
5 Design of an injectable polypeptide hydrogel depot containing the immune checkpoint blocker anti-PD-L1 and doxorubicin to enhance antitumor combination therapy 期刊论文 Yingge Shi;Dong Li;Chaoliang He;Xuesi Chen
6 肿瘤微环境刺激响应性纳米药物递送材料研究 奖励 陈莉;贺超良;丁建勋;张喆;陈笑非;姚雪枚
7 Thermo-induced physically crosslinked polypeptide-based block copolymer hydrogels for biomedical applications 期刊论文 Dan Zhao;Yan Rong;Dong Li;Chaoliang He;Xuesi Chen
8 A fast and versatile cross-linking strategy via o-phthalaldehyde condensation for mechanically strengthened and functional hydrogels 期刊论文 Zhen Zhang;Chaoliang He;Yan Rong;Hui Ren;Tianran Wang;Zheng Zou;Xuesi Chen
9 Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure 期刊论文 Hui Ren;Zhen Zhang;Xueliang Cheng;Zheng Zou;Xuesi Chen;Chaoliang He
10 Enhanced antitumor chemo-immunotherapy by local co-delivery of chemotherapeutics, immune checkpoint blocking antibody and IDO inhibitor using an injectable polypeptide hydrogel 期刊论文 Junfeng Ding;Tianran Wang;Zhixiong Chen;Zhiqiang Lin;Xuesi Chen;Chaoliang He
11 Recent advances in organic and polymeric carriers for local tumor chemo-immunotherapy 期刊论文 YiTing Bai;TianRan Wang;SongLing Zhang;XueSi Chen;ChaoLiang He
12 一种肉桂醛修饰的聚乙二醇-聚氨基酸嵌段共聚物、其制备方法及水凝胶 专利 贺超良;陈志雄;陈学思
13 Injectable antibacterial tissue-adhesive hydrogel based on biocompatible o-phthalaldehyde/amine crosslinking for efficient treatment of infected wounds 期刊论文 Zheng Zou;Zhen Zhang;Hui Ren;Xueliang Cheng;Xuesi Chen;Chaoliang He
14 A pH-triggered self-unpacking capsule containing zwitterionic hydrogel-coated MOF nanoparticles for efficient oral exendin-4 delivery 期刊论文 Yuhao Zhou;Zhixiong Chen;Dan Zhao;Dong Li;Chaoliang He;Xuesi Chen
15 Stimuli‐responsive hydrogel adhesives for wound closure and tissue regeneration 期刊论文 Hui Ren;Zhen Zhang;Xuesi Chen;Chaoliang He
16 一种MMP酶响应的可注射聚氨基酸水凝胶及其制备方法和应用 专利 贺超良;梁爽;荣岩;陈学思
17 Mucoadhesive, Antibacterial, and Reductive Nanogels as a Mucolytic Agent for Efficient Nebulized Therapy to Combat Allergic Asthma 期刊论文 Dan Zhao;Dong Li;Xueliang Cheng;Zheng Zou;Xuesi Chen;Chaoliang He
18 Injectable click polypeptide hydrogels via tetrazine-norbornene chemistry for localized cisplatin release 期刊论文 Zhen Zhang;Chaoliang He;Xuesi Chen
19 Effect of polymer topology and residue chirality on biodegradability of polypeptide hydrogels 期刊论文 Dong Li;Shun Shi;Dan Zhao;Yan Rong;Yuhao Zhou;Junfeng Ding;Chaoliang He;Xuesi Chen
20 Crucial impact of residue chirality on the gelation process and biodegradability of thermoresponsive polypeptide hydrogels 期刊论文 Dong Li;Dan Zhao;Chaoliang He;Xuesi Chen
21 An adhesive immune-stimulating multifunctional hydrogel for potent tumor chemoimmunotherapy and postoperative wound healing promotion 期刊论文 Tianran Wang;Junfeng Ding;Shuang Liang;Zhiqiang Lin;Jiaxuan Yang;Zhen Zhang;Zheng Zou;Gao Li;Xuesi Chen;Chaoliang He
22 Injectable polypeptide hydrogel depots containing dual immune checkpoint inhibitors and doxorubicin for improved tumor immunotherapy and post-surgical tumor treatment 期刊论文 Zhixiong Chen;Yan Rong;Junfeng Ding;Xueliang Cheng;Xuesi Chen;Chaoliang He
23 Rapidly thermoreversible and biodegradable polypeptide hydrogels with sol–gel–sol transition dependent on subtle manipulation of side groups 期刊论文 Dan Zhao;Dong Li;Fenli Quan;Yuhao Zhou;Zhen Zhang;Xuesi Chen;Chaoliang He
24 Injectable hydrogels as local depots at tumor sites for antitumor immunotherapy and immune-based combination therapy 期刊论文 Hongyu Ma;Chaoliang He;Xuesi Chen
25 Influence of residual chirality on the conformation and enzymatic degradation of glycopolypeptide based biomaterials 期刊论文 Shun Shi;Jiayu Wang;Tianran Wang;Hui Ren;Yuhao Zhou;Gao Li;Chaoliang He;Xuesi Chen
26 Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells 期刊论文 Yan Rong;Zhen Zhang;Chaoliang He;Xuesi Chen
27 Injectable chitosan hydrogels loaded with antioxidant agent as first-aid dressings for second-degree burn wounds 期刊论文 Hui Ren;Zhen Zhang;Kailun Lu;Yuanyuan Shen;Chaoliang He;Xuesi Chen
28 侧基可功能化的聚氨基酸嵌段聚合物、其制备方法及响应型可逆粘附性可注射水凝胶 专利 贺超良;时莹歌;陈学思
29 A nanocomposite vehicle based on metal-organic framework nanoparticle incorporated biodegradable microspheres for enhanced oral insulin delivery 期刊论文 Yuhao Zhou;Liang Liu;Yue Cao;Shuangjiang Yu;Chaoliang He;Xuesi Chen
30 pH- and temperature-responsive hydrogels based on tertiary amine-modified polypeptides for stimuli-responsive drug delivery 期刊论文 Zhiqiang Lin;Junfeng Ding;Xuesi Chen;Chaoliang He
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