开发标的结核分枝杆菌二萜烯合成酶之抗生素：蛋白质晶体结构与高通量筛选
31470240
2014
C0108.病原细菌学
郭瑞庭
面上项目
教授
中国科学院天津工业生物技术研究所
85万元
蛋白质晶体结构;结核分枝杆菌;二萜烯合成酶;药物筛选
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Functionaland structural analyses of a 1,4- β-endoglucanase from Ganoderma lucidum | 期刊论文 | Liu Guizhi;Li Qian;Shang Na;Huang Jian-Wen;Ko Tzu-Ping;Liu Weidong;Zheng Yingying;Han Xu;Chen Yun;Chen Chun-Chi;Jin Jian;Guo Rey-Ting |
| 2 | Structural studies reveal the molecular mechanism of PETase | 期刊论文 | Chen Chun-Chi;Han Xu;Ko Tzu-Ping;Liu Weidong;Guo Rey-Ting |
| 3 | Bacterial cell growth inhibitors targeting undecaprenyl diphosphate synthase and undecaprenyl diphosphate phosphatase. | 期刊论文 | Wang Yang;Desai Janish;Zhang Yonghui;Malwal Satish R;Shin Christopher J;Feng Xinxin;Sun Hong;Liu Guizhi;Guo Rey-Ting;Oldfield Eric |
| 4 | The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement | 期刊论文 | Chen Chun-Chi;Hu Xiangying;Tang Xueke;Yang Yunyun;Ko Tzu-Ping;Gao Jian;Yingying Zheng;Huang Jian-Wen;Yu Zhengsen;Li Liping;Han Shuai;Cai Ningning;Zhang Yonghui;Liu Weidong;Guo Rey-Ting |
| 5 | Head-to-Head Prenyl Synthases in Pathogenic Bacteria | 期刊论文 | Schwalen Christopher J.;Feng Xinxin;Liu Weidong;O-Dowd Bing;Ko Tzu-Ping;Shin Christopher J.;Guo Rey-Ting;Mitchell Douglas A.;Oldfield Eric |
| 6 | 內酯酶及利用內酯酶降解 α-玉米赤黴烯醇的方 法 | 专利 | 郭瑞庭;鄭迎迎;許中霞;陳純琪;彭衛;劉衛東;劉嚞睿;馬延和 |
| 7 | Functional and structural analysis of Pichia pastoris-expressed Aspergillus niger 1,4-beta-endoglucanase | 期刊论文 | Yan Junjie;Liu Weidong;Li Yujie;Lai Hui-Lin;Zheng Yingying;Huang Jian-Wen;Chen Chun-Chi;Chen Yun;Jin Jian;Li Huazhong;Guo Rey-Ting |
| 8 | “Head-to-middle” and “head-to-tail” cis-prenyl transferases: structure of isosesquilavandulyl diphosphate synthase (Cover story) | 期刊论文 | Gao Jian;Ko Tzu-Ping;Chen Lu;Satish R. Malwal;Zhang Jianan;Hu Xiangying;Qu Fiona;Liu Weidong;Huang Jian-Wen;Cheng Ya-Shan;Chen Chun-Chi;Yang Yunyun;Zhang Yonghui;Eric Oldfield;Guo Rey-Ting |
| 9 | Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis | 期刊论文 | Wang Jing;Chen Chun-Chi;Yang Yunyun;Liu Weidong;Ko Tzu-Ping;Shang Na;Hu Xiangying;Xie Yonghua;Huang Jian-Wen;Zhang Yonghui;Guo Rey-Ting |
| 10 | Structure, function, and inhibition of Staphylococcus aureus heptaprenyl diphosphate synthase | 期刊论文 | Desai Janish;Liu Yi-Liang;Wei Hongli;Liu Weidong;Ko Tzu-Ping;Guo Rey-Ting;Oldfield Eric |
| 11 | Moenomycin biosynthesis: structure and mechanism of action of the prenyltransferase MoeN5 | 期刊论文 | Zhang Lilan;Chen Chun-Chi;Ko Tzu-Ping;Huang Jian-Wen;Zheng Yingying;Liu Weidong;Wang Iren;Malwal Satish R.;Feng Xinxin;Wang Ke;Huang Chun-Hsiang;Hsu Shang-Te Danny;Wang Andrew H.-J.;Oldfield Eric;Guo Rey-Ting |
| 12 | Structure and function of a "head-to-middle"prenyltransferase: lavandulyl diphosphate synthase (Cover story) | 期刊论文 | Liu Meixia;Chen Chun-Chi;Chen Lu;Xiao Xiansha;Zheng Yingying;Huang Jian-Wen;Liu Weidong;Ko Tzu-Ping;Cheng Ya-Shan;Feng Xinxin;Oldfield Eric;Guo Rey-Ting;Ma Yanhe |
| 13 | Structural insight into catalytic mechanism of PET hydrolase | 期刊论文 | Han Xu;Liu Weidong;Huang Jian-Wen;Ma Jiantao;Zheng Yingying;Ko Tzu-Ping;Xu Limin;Cheng Ya-Shan;Chen Chun-Chi;Guo Rey-Ting |
| 14 | Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-β-endoglucanase from Thielavia terrestris | 期刊论文 | Gao Jian;Huang Jian-Wen;Li Qian;Liu Weidong;Ko Tzu-Ping;Zheng Yingying;Xiao Xiansha;Kuo Chih-Jung;Chen Chun-Chi;Guo Rey-Ting |
| 15 | Structures of trypanosome vacuolar soluble pyrophosphatases: anti-parasitic drug targets | 期刊论文 | Yang Yunyun;Ko Tzu-Ping;Chen Chun-Chi;Huang Guozhong;Zheng Yingying;Liu Weidong;Wang Iren;Ho Meng-Ru;Hsu Shang-Te Danny;Dowd Bing O’;Huff Hannah C;Huang Chun-Hsiang;Docampo Roberto;Oldfield Eric;Guo Rey Ting |
| 16 | Crystal Structure of a Mycoestrogen-Detoxifying Lactonase from Rhinocladiella mackenziei: Molecular Insight into ZHD Substrate Selectivity | 期刊论文 | Zheng Yingying;Liu Wenting;Chen Chun-Chi;Hu Xiangying;Liu Weidong;Ko Tzu-Ping;Tang Xueke;Wei Hongli;Huang Jian-Wen;Guo Rey-Ting |
| 17 | 内酯酶及利用内酯酶降解 α-玉米赤霉烯醇的方法 | 专利 | 郭瑞庭;郑迎迎;许中霞;陈纯琪;彭卫;刘卫东;刘嚞睿;马延和 |
| 18 | Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50 | 期刊论文 | Huang Jian-Wen;Liu Weidong;Lai Hui-Lin;Cheng Ya-Shan;Zheng Yingying;Li Qian;Sun Hong;Kuo Chih-Jung;Guo Rey-Ting;Chen Chun-Chi |
| 19 | LACTONE HYDROLASE AND METHOD OF DEGRADING ALPHA-ZEARALENOL USING THE SAME | 专利 | Guo Rey-Ting;Zheng Ying-Ying;Xu Zhong-Xia;Chen Chun-Chi;Peng Wei;Liu Wei-Dong;Liu Je-Ruei;Ma Yan-He |
| 20 | Enhanced alpha-zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering (Cover story) | 期刊论文 | Xu Zhongxia;Liu Weidong;Chen Chun-Chi;Li Qian;Huang Jian-Wen;Ko Tzu-Ping;Liu Guizhi;Liu Wenting;Peng Wei;Cheng Ya-Shan;Chen Yun;Jin Jian;Li Huazhong;Zheng Yingying;Guo Rey-Ting |
| 21 | Structure and function of a "head-to-middle"prenyltransferase: lavandulyl diphosphate synthase (Cover story) | 期刊论文 | Liu Meixia;Chen Chun-Chi;Chen Lu;Xiao Xiansha;Zheng Yingying;Huang Jian-Wen;Liu Weidong;Ko Tzu-Ping;Cheng Ya-Shan;Feng Xinxin;Oldfield Eric;Guo Rey-Ting;Ma Yanhe |
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