Toll样蛋白受体13的天然免疫识别
21877106
2018
B0707.化学生物学理论、方法与技术
王晓辉
面上项目
研究员
中国科学院长春应用化学研究所
63万元
分子识别;核糖核酸;Toll样受体蛋白13;分子动力学模拟;生物物理化学
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | ACT001 Inhibits TLR4 Signaling by Targeting Co-Receptor MD2 and Attenuates Neuropathic Pain | 期刊论文 | Tianshu Zhang;Cong Lin;Siru Wu;Sha Jin;Xiaodong Li;Yinghua Peng;Xiaohui Wang |
| 2 | Nalmefene non-enantioselectively targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling: wet-lab techniques and in silico simulations | 期刊论文 | Zhang Xiaozheng;Wang Hongshuang;Wang Yibo;Li Hongyuan;Wu Siru;Gao Jingwei;Zhang Tianshu;Xie Jun;Wang Xiaohui |
| 3 | Dissecting Role of Charged Residue from Transmembrane Domain 5 of Latent Membrane Protein 1 via In Silico Simulations and Wet-Lab Experiments | 期刊论文 | Yibo Wang;Bo Zhang;Cong Lin;Ying Liu;Min Yang;Yinghua Peng;Xiaohui Wang |
| 4 | Small-Molecule Modulators of Toll-like Receptors | 期刊论文 | Wang Yibo;Zhang Shuting;Li Hongyuan;Wang Hongshuang;Zhang Tianshu;Hutchinson Mark;Yin Hang;Wang Xiaohui |
| 5 | Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions | 期刊论文 | Lushpa Vladislav A.;Goncharuk Marina V;Lin Cong;Zalevsky Arthur O.;Talyzina Irina A.;Luginina Aleksandra P.;Vakhrameev Daniil D.;Shevtsov Mikhail B.;Goncharuk Sergey A.;Arseniev Alexander S.;Borshchevskiy Valentin I;Wang Xiaohui;Mineev Konstantin S. |
| 6 | Cannabidiol-dihydroartemisinin conjugates for ameliorating neuroinflammation with reduced cytotoxicity | 期刊论文 | Fanfan Wang;Ming Li;Cong Lin;Sha Jin;Hongyuan Li;Yuyuan Lu;Hengshan Wang;Hongshuang Wang;Xiaohui Wang |
| 7 | Exploring the trimerization process of a transmembrane helix with an ionizable residue by molecular dynamics simulations: a case study of transmembrane domain 5 of LMP-1 | 期刊论文 | Bo Zhang;Yinghua Peng;Yibo Wang;Xiaohui Wang |
| 8 | Targeting the transmembrane domain 5 of latent membrane protein 1 using small molecule modulators | 期刊论文 | Zhang Bo;Wang Yibo;Lin Cong;Li Hongyuan;Wang Xiaojie;Peng Yinghua;Mineev Konstatin S.;Wilson Andrew J.;Wang Hongshuang;Wang Xiaohui |
| 9 | Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood–brain barrier leakage in mice | 期刊论文 | Zhang Tianshu;Zhang Xiaozheng;Lin Cong;Wu Siru;Wang Fanfan;Wang Hongshuang;Wang Yibo;Hutchinson Mark R.;Peng Yinghua;Li Hongyuan;Wang Xiaohui |
| 10 | Exploring the Thermodynamics of 7-Amino Actinomycin D-Induced Single-Stranded DNA Hairpin by Spectroscopic Techniques and Computational Simulations | 期刊论文 | Yinghua Peng;Yibo Wang;Xiaohui Wang |
| 11 | Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2 | 期刊论文 | Siru Wu;Cong Lin;Tianshu Zhang;Bo Zhang;Yushan Jin;Hongshuang Wang;Hongyuan Li;Yibo Wang;Xiaohui Wang |
| 12 | Dissecting the Role of N-Glycan at N413 in Toll-like Receptor 3 via Molecular Dynamics Simulations | 期刊论文 | Yibo Wang;Siru Wu;Cong Zhang;Yushan Jin;Xiaohui Wang |
| 13 | Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling | 期刊论文 | Hongyuan Li;Yinghua Peng;Cong Lin;Xiaozheng Zhang;Tianshu Zhang;Yibo Wang;Yuanpeng Li;Siru Wu;Hongshuang Wang;Mark R. Hutchinson;Linda R. Watkins;Xiaohui Wang |
| 14 | Structure-activity relationship study of dihydroartemisinin C-10 hemiacetal derivatives as Toll-like receptor 4 antagonists | 期刊论文 | Wang Shuo;Wang Hongshuang;Lin Cong;Zhang Tianshu;Gao Jingwei;Wu Siru;Wang Yibo;Li Hongyuan;Min Weihong;Liu Chunlei;Wang Xiaohui |
| 15 | Stereochemistry and innate immune recognition:(+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling | 期刊论文 | Zhang Xiaozheng;Peng Yinghua;Grace Peter M.;Metcalf Matthew D.;Kwilasz Andrew J.;Wang Yibo;Zhang Tianshu;Wu Siru;Selfridge Brandon R.;Portoghese Philip S.;Rice Kenner C.;Watkins Linda R.;Hutchinson Mark R.;Wang Xiaohui |
| 16 | Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide | 期刊论文 | Yibo Wang;Yinghua Peng;Bo Zhang;Xiaozheng Zhang;Hongyuan Li;Andrew J.Wilson;Konstantin S.Mineev;Xiaohui Wang |
| 17 | Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain. | 期刊论文 | Yinghua Peng;Xiaozheng Zhang;Tianshu Zhang;Peter M. Grace;Hongyuan Li;Yibo Wang;Hang Li;Hongqian Chen;Linda R. Watkins;Mark R. Hutchinson;Xiaohui Wang |
| 18 | Peptide-based inhibitors of protein–protein interactions: biophysical, structural and cellular consequences of introducing a constraint | 期刊论文 | Hongshuang Wang;Robert S. Dawber;Peiyu Zhang;Martin Walko;Andrew J. Wilson;Xiaohui Wang |
| 19 | Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell | 期刊论文 | Wang Xiaohui;Northcutt Alexis L;Cochran Thomas A;Zhang Xiaozheng;Fabisiak Timothy J;Haas Mackenzie E;Amat Jose;Li Hongyuan;Rice Kenner C;Maier Steven F;Bachtell Ryan K;Hutchinson Mark R;Watkins Linda R |
| 20 | TLR4 biased small molecule modulators. | 期刊论文 | Lin Cong;Wang Hongshuang;Zhang Miyuan;Mustafa Sanam;Wang Yibo;Li Hongyuan;Yin Hang;Hutchinson Mark R.;Wang Xiaohui |
| 21 | Exploring Methamphetamine Nonenantioselectively Targeting Toll-like Receptor 4/Myeloid Differentiation Protein 2 by in Silico Simulations and Wet-Lab Techniques | 期刊论文 | Zhang Xiaozheng;Wang Yibo;Wang Hongshuang;Li Hongyuan;Zhang Tianshu;Peng Yinghua;Wang Xiaohui |
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