抗包虫先导化合物结构优化及活性筛选平台的建立
U1803282
2018
李军
联合基金项目
研究员
新疆医科大学
258万元
结构优化改造;活性筛选平台;创新药;包虫病;蠕虫
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 丝氨酸蛋白酶在细粒棘球绦虫中的表达及活性鉴定 | 期刊论文 | 田梦潇;臧小燕;郭刚;齐文静;郭宝平;任远;李军;张文宝 |
| 2 | Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections | 奖励 | 李军;王味思;姚俊敏 |
| 3 | Echinococcus granulosus sensu stricto and antigen B may decrease infammatory bowel disease through regulation of M1/2 | 期刊论文 | Jianling Bao;Wenjing Qi;Chang Sun;Mengxiao Tian;Hongjie Jiao;Gang Guo;Baoping Guo;Yuan Ren;Huajun Zheng;Yuezhu Wang;Mei Yan;Zhaoxia Zhang;Donald P.McManus;Jun Li;Wenbao Zhang |
| 4 | Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice | 期刊论文 | Wang Weisi;Yao Junmin;Chen Zhuo;Sun Yiming;Shi Yuqing;Wei Yufen;Zhou Hejun;Yu Yingfang;Li Shizhu;Duan Liping |
| 5 | 新疆察布查尔县小型啮齿类动物多房棘球蚴感染情况调查 | 期刊论文 | 郭宝平;郭刚;张莉;向晶晶;王小平;任远;齐文静;张慧;李军;张文宝;汪海燕 |
| 6 | 2019年度新疆维吾尔自治区外国专家“天山奖” | 奖励 | 李军 |
| 7 | 一种抑制剂在制备治疗囊型包虫病药物方面的用途 | 专利 | 张文宝;李军;王甜;郑雪婷 |
| 8 | 抗包虫的咔唑氨基醇类化合物的药物新用途 | 专利 | 张文宝;李军;武娟;张慧;齐文静;王味思;段李平;吴川川;田梦潇;龚巧巧;艾柯代·卡得 |
| 9 | Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections | 期刊论文 | Jun Li;Weisi Wang;Junmin Yao;Tian Wang;Shi-Zhu Li;Wenjing Qi;Shuai Han;Yuan Ren;Zhisheng Dang;Xiumin Han;Gang Guo;Baoping Guo;Liqin Wang;Liping Duan;Wenbao Zhang |
| 10 | Bioinformatic comparison of Kunitz protease inhibitors in Echinococcus granulosus sensu strictoand E. multilocularis and the genes expressed in different developmental stages of E. granulosuss.s. | 期刊论文 | Hui Zhang;Mengxiao Tian;Wenjing Qi;Juan Wu;Huajun Zheng;Gang Guo;Liang Zhang;Shiwanthi L. Ranasinghe;Donald P. McManus;Jun Li;Wenbao Zhang |
| 11 | 中国畜牧兽医学会兽医寄生虫学分会第16次学术研讨会,第一届“正典杯”优秀论文二等奖 | 奖励 | 王味思;李军 |
| 12 | Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine | 期刊论文 | Yingfang Yu;Jun Li;Weisi Wang;Tian Wang;Wenjing Qi;Xueting Zheng;Lei Duan;Jia-Xu Chen;Shi-Zhu Li;Xiumin Han;Wenbao Zhang;Liping Duan |
| 13 | 咔唑氨基醇类化合物及其制备方法和抗寄生虫的用途 | 专利 | 段李平;李军;王味思;张文宝 |
| 14 | 咔唑氨基醇化合物H1402对棘球蚴感染小鼠组织淋巴细胞及其亚群的影响 | 期刊论文 | 武娟;齐文静;张慧;吴川川;焦红杰;黎飞海;艾柯代·卡得;帕力塔吉·麦麦提祖农;张星星;田梦潇;龚巧巧;刘丽英;吾丽凡;李军;张文宝 |
| 15 | High endemicity of alveolar echinococcosis in Yili Prefecture, Xinjiang Autonomous Region, the People’s Republic of China: Infection status in different ethnic communities and in small mammals | 期刊论文 | Baoping Guo;Zhuangzhi Zhang;Yongzhong Guo;Gang Guo;Haiyan Wang;Jianjun Ma;Ronggui Chen;Xueting Zheng;Jianling Bao;Li He;Tian Wang;Wenjing Qi;Mengxiao Tian;Junwei Wang;Canlin Zhou;Patrick Giraudoux;Christopher G. Marston;Donald P. McManus;Wenbao Zhang;Jun Li |
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