组蛋白去乙酰化酶抑制剂Lar-7的构效关系及其抗肿瘤活性的研究

21172220
2011
B0706.药物化学生物学
蒋晟
面上项目
教授
中国科学院广州生物医药与健康研究院
60万元
肿瘤;组蛋白去乙酰化酶;Lar-7;构效关系;抑制剂
2012-01-01到2015-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Identification of an Annonaceous Acetogenin Mimetic, AA005, as an AMPK Activator and Autophagy Inducer in Colon Cancer Cells 期刊论文 Xiao, Qi-Cai|Jiang, Sheng|Yao, Zhu-Jun|Zhou, Guang-Biao|
2 PQJS380 A novel lead compound to induce apoptosis in acute lymphoblastic leukemia cells 期刊论文 Yao, Yiwu|Chen, Dong|Xue, Hongman|Pan, Jingxuan|
3 Discovery of Novel Class I Histone DeacetylaseInhibitors with Promising in Vitro Selectivity for Cancers Cells and in VivoAntitumor Activities 期刊论文 S. Li|H. Yao|Z. Li|Sheng Jiang|
4 Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors 期刊论文 Meng QingQing|Yao RiSheng|Li Zheng|Jiang Sheng|
5 Design, synthesis, and biological evaluation of 1, 3-disubstitutedpyrazolederivatives as new class I and IIb histone deacetylaseinhibitors 期刊论文 Q. Sun|C. Liu|Z. Tu|蒋晟|
6 The application of click chemistry in thesynthesis of agents with anticancer activity 期刊论文 Y. Wang,|B. Zhao|W.-C. Ye|Sheng Jiang|
7 Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors 期刊论文 Liu, Chunping|Yang, Yang|Tu, Zhengchao|Jiang, Sheng|
8 Design, synthesis, and biological evaluation of largazole derivatives:alteration of the zinc-binding domain 期刊论文 X. Li|D. Zhang|Z. Tu|蒋晟|
9 2-Carbomethoxy-3-hydroxyquinoxaline-di-N-oxide as a novel ligand for the copper-catalyzed coupling reaction of phenols and aryl halides. 期刊论文 Yatao Qiu , Weijun Jia , Zhiyi Yao , Fanhong Wu|Sheng Jiang|
10 Biological Evaluation of New Largazole Analogues: Alteration of Macrocyclic Scaffold with Click Chemistry 期刊论文 Sun, Qiao|Yao, Yiwu|Liu, Jinsong|Jiang, Sheng|
11 Design, synthesis, and biological evaluation of largazole derivatives: alteration of the zinc-binding domain 期刊论文 Li, Xianling|Zhang, Dayong|Tu, Zhengchao|Jiang, Sheng|
12 Comprehensive Analysis for Histone Acetylation of Human Colon Cancer Cells Treated with a novel HDAC Inhibitor 期刊论文 Ma, Zhenyi|Xu, Liyan|Li, Enmin|Zhang, Kai|
13 Synthesis of 3-[(Z)-Pentadec-8-enyl]catechol and Its Anti-angiogenesis Activity 期刊论文 Yang Mei|He Jiangbo|Cheng Yongxian|Jiang Sheng|
14 New Ligands for Copper-Catalyzed C-N Coupling Reactions at Gentle Temperature 期刊论文 Su, Jinyue|Qiu, Yatao|Jiang, Sheng|Zhang, Dayong|
15 Suberoylanilide hydroxamic acid suppresses inflammation-induced neovascularization 期刊论文 Zhou, Hongyan|Jiang, Sheng|Chen, Jianping|Su, Shao Bo|
16 Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry 期刊论文 Xue, Xiaowen|Liu, Jinsong|Tu, Zhengchao|Jiang, Sheng|
17 Total synthesis of securinega alkaloids (-)-norsecurinine, (-)-niruroidine and (-)-flueggine A 期刊论文 Zhao, Bing-Xin|Wang, Ying|Ye, Wen-Cai|Jiang, Sheng|
18 Identification of novel bivalent mimetics of annonaceous acetogenins via a scaffold-hopping strategy 期刊论文 Li, Zhen|Zhou, Guang-Biao|Yao, Zhu-Jun|Jiang, Sheng|
19 Largazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells 期刊论文 Wei, Ming-Ming|Liu, Zi|Jiang, Sheng|Zhou, Guang-Biao|
20  Total synthesis of securinega alkaloids (-)-norsecurinine, (-)-niruroidine and (-)-flueggine A. 期刊论文 B.-X. Zhao|Y. Wang|W.-C. Ye*,|蒋晟|
21 组蛋白去乙酰化酶抑制剂抗肿瘤临床研究进展 期刊论文 姚毅武|姚和权|蒋晟|薛晓文|
22 组蛋白去乙酰化酶抑制剂抗肿瘤临床研究进展 期刊论文 姚毅武|姚和权|蒋晟|薛晓文|
23 Biological evaluation of new mimetics of annonaceous acetogenins: Alteration of right scaffold by click linkage with aromatic functionalities 期刊论文 Qiu, Yatao|Zhou, Guang-Biao|Yao, Zhu-Jun|Jiang, Sheng|
24 Largazole, an inhibitor of class I histone deacetylases, attenuates inflammatory corneal neovascularization 期刊论文 Chen, Jianping|Ren, Xiangrong|Jin, Jiayi|Su, Shao Bo|
25 全新的Largazole类似物的生物活性评价:通过点击化学改变大环的构想 期刊论文 蒋晟|
26 Largazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells 期刊论文 蒋晟|
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