基于长寿人群探索“菌群-脑-肠轴”平衡的正性作用和机制
91849132
2018
H1901.衰老机制与调控
孙亮
重大研究计划
研究员
北京医院
50万元
正性作用;长寿;老年综合评估;脑肠轴;健康老龄化
2019-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | A single-cell transcriptomic atlas of primate pancreatic islet aging | 期刊论文 | Li Jingyi;Zheng Yuxuan;Yan Pengze;Song Moshi;Wang Si;Sun Liang;Liu Zunpeng;Ma Shuai;Belmonte Juan Carlos Izpisua;Chan Piu;Zhou Qi;Zhang Weiqi;Liu Guanghui;Tang Fuchou;Qu Jing |
| 2 | 广西壮族自治区南宁市上林地区长寿人群分布特征和影响因素研究 | 期刊论文 | 苏华斌;倪晓琳;王钊平;张丽;庞国防;吕渊;张为;原慧萍;孙亮;杨泽;胡才友 |
| 3 | Single-Cell Transcriptomic Atlas of Primate Ovarian Aging | 期刊论文 | Wang Si;Zheng Yuxuan;Li Jingyi;Yu Yang;Zhang Weiqi;Song Moshi;Liu Zunpeng;Min Zheying;Hu Huifang;Jing Ying;He Xiaojuan;Sun Liang;Ma Lifang;Esteban Concepcion Rodriguez;Chan Piu;Qiao Jie;Zhou Qi;Belmonte Juan Carlos Izpisua;Qu Jing;Tang Fuchou;Liu Guang-Hui |
| 4 | Identification of cardiovascular health gene variants related to longevity in a Chinese population | 期刊论文 | Zhang Li;Bai Chen;Nie Chao;Zhu Xiaoquan;Yuan Huiping;Sun Liang;Zhou Qi;Li Xiaoling;Xian Xuan;Yang Fan;Pang Guofang;Lv Yuan;Ni Xiaolin;Hu Caiyou;Yang Ze |
| 5 | Association between IL-1B (-511)/IL-1RN (VNTR) polymorphisms and type 2 diabetes: a systematic review and meta-analysis | 期刊论文 | Jiao J;Wang Z;Guo Y;Liu J;Huang X;Ni X;Gao D;Sun L;Zhu X;Zhou Q;Yang Z;Yuan H |
| 6 | A description of the relationship in healthy longevity and aging-related disease: from gene to protein | 期刊论文 | Xiaolin Ni;Zhaoping Wang;Danni Gao;Huiping Yuan;Liang Sun;Xiaoquan Zhu;Qi Zhou;Ze Yang |
| 7 | DNA损伤在衰老相关疾病中的研究进展 | 期刊论文 | 张楠;周起;陈晨;张莹;原慧萍;杨泽;吴铸;孙亮 |
| 8 | A single-cell transcriptomic landscape of the lungs of patients with COVID-19 | 期刊论文 | Wang S;Yao X;Ma S;Ping Y;Fan Y;Sun S;He Z;Shi Y;Sun L;Xiao S;Song M;Cai J;Li J;Tang R;Zhao L;Wang C;Wang Q;Zhao L;Hu H;Liu X;Sun G;Chen L;Pan G;Chen H;Li Q;Zhang P;Xu Y;Feng H;Zhao GG;Wen T;Yang Y;Huang X;Li W;Liu Z;Wang H;Wu H;Hu B;Ren Y;Zhou Q;Qu J;Zhang W;Liu GH;Bian XW |
| 9 | 基于遗传病因识别的老年性痴呆早期诊断方法及干预新技术 | 奖励 | 孙亮 |
| 10 | 肥胖与肠道Akkermansia菌相关性及其在老年人群中的特征 | 期刊论文 | 周起;董飞;李婉西;陈晨;张楠;吴铸;杨泽;孙亮 |
| 11 | 用以评估和校准人类生物学年龄的表观遗传学时钟的构建 | 期刊论文 | 倪晓琳;原慧萍;焦娟;王钊平;苏华斌;吕渊;庞国防;张为;孙亮;胡才友; 杨泽 |
| 12 | Association Between Gut Akkermansia and Metabolic Syndrome is Dose-Dependent and Affected by Microbial Interactions: A Cross-Sectional Study | 期刊论文 | Zhou Qi;Pang Guofang;Zhang Zhirong;Yuan Huiping;Chen Chen;Zhang Nan;Yang Ze;Sun Liang |
| 13 | Reservoir hosts prediction for COVID-19 by hybrid transfer learning model | 期刊论文 | Yang Yun;Guo Jing;Wang Pei;Wang Yaowei;Yu Minghao;Wang Xiang;Yang Po;Sun Liang |
| 14 | 高龄老人重要健康相关指标的流行病学研究和应用 | 奖励 | 孙亮 |
| 15 | 通过脑肠轴血清代谢物评估老年人认知功能的可行性研究 | 期刊论文 | 吴铸;周起;李颖;张楠;刘恒硕;陈晨;庞国防;梁庆华;胡才友;原慧萍;杨泽;孙亮 |
| 16 | 生物学年龄在健康老龄化中的研究进展 | 期刊论文 | 陈晨;张莹;杨睿悦;周起;栗向辉;杨泽;孙亮 |
| 17 | 广西壮族自治区多地区长寿人群分布特征及其相关因素研究 | 期刊论文 | 倪晓琳;张丽;王钊平;苏华斌;庞国防;吕渊;张为;原慧萍;孙亮;杨泽;胡才友 |
| 18 | 中国人类健康长寿相关因素的研究进展 | 期刊论文 | 孙亮;黎健 |
| 19 | Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county | 期刊论文 | Zhang Ying;Zhou Qi;Yang Ruiyue;Hu Caiyou;Huang Zezhi;Zheng Chenguang;Liang Qinghua;Gong Ranhui;Zhu Xiaoquan;Gong Huan;Yuan Huiping;Chen Chen;Li Xianghui;Zhang Nan;Yang Ze;Sun Liang |
| 20 | Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective | 期刊论文 | Wang Zhaoping;Ni Xiaolin;Zhang Li;Sun Liang;Zhu Xiaoquan;Zhou Qi;Yang Ze;Yuan Huiping |
| 21 | Gut bacteria Akkermansia is associated with reduced risk of obesity: evidence from the American Gut Project | 期刊论文 | Qi Zhou;Yanfeng Zhang;Xiaoxia Wang;Ruiyue Yang;Xiaoquan Zhu;Ying Zhang;Chen Chen;Huiping Yuan;Ze Yang;Liang Sun |
| 22 | Copper exposure association with prevalence of non-alcoholic fatty liver disease and insulin resistance among US adults (NHANES 2011-2014) | 期刊论文 | Chen Chen;Zhou Qi;Yang Ruiyue;Wu Zhu;Yuan Huiping;Zhang Nan;Zhi Mingchun;Zhang Ying;Ni Xiaolin;Wang Zhaoping;Gao Danni;Zhu Xiaoquan;Cai Jianping;Yang Ze;Sun Liang |
| 23 | Single-cell transcriptomic atlas of primate cardiopulmonary aging | 期刊论文 | Ma Shuai;Sun Shuhui;Li Jiaming;Fan Yanling;Qu Jing;Sun Liang;Wang Si;Zhang Yiyuan;Yang Shanshan;Liu Zunpeng;Wu Zeming;Zhang Sheng;Wang Qiaoran;Zheng Aihua;Duo Shuguang;Yu Yang;Belmonte Juan Carlos Izpisua;Chan Piu;Zhou Qi;Song Moshi;Zhang Weiqi;Liu Guanghui |
| 24 | Investigation of the Reference Interval Values of Fasting Plasma Glucose, Blood Pressure, and Blood Lipids in the Longevity People Aged 90 Years Old and Above | 期刊论文 | Zhaoping Wang;Xiaolin Ni;Danni Gao;Liang Sun;Xiaoquan Zhu;Juan Jiao;Qi Zhou;Chen Chen;Nan Zhang;Zhu Wu;Ze Yang;Huiping Yuan |
| 25 | FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction | 期刊论文 | Lei Jinghui;Wang Si;Kang Wang;Chu Qun;Liu Zunpeng;Sun Liang;Ji Yun;Esteban Concepcion Rodriguez;Yao Yan;Belmonte Juan Carlos Izpisua;Chan Piu;Liu Guang-Hui;Zhang Weiqi;Song Moshi;Qu Jing |
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