蛋白磷酸酶4经RAC1/MLK3/JNK信号通路调节肝细胞脂性凋亡参与NASH进程的机制研究
81770858
2017
H0710.脂质代谢异常
黄秀清
面上项目
研究员
北京医院
53万元
脂性凋亡;蛋白磷酸酶4;脂代谢紊乱;非酒精性脂肪性肝炎;脂毒性
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 肝细胞脂性凋亡在NASH中的作用和机制研究 | 期刊论文 | 陈皓;窦琳;杨光;沈涛;唐蔚青;满永;张曦月;黄秀清 |
| 2 | Dexrazoxane Protects Cardiomyocyte from Doxorubicin-Induced Apoptosis by Modulating miR-17-5p | 期刊论文 | Yu Xiaoxue;Ruan Yang;Shen Tao;Qiu Quan;Yan Mingjing;Sun Shenghui;Dou Lin;Huang Xiuqing;Wang Que;Zhang Xiyue;Man Yong;Tang Weiqing;Jin Zening;Li Jian |
| 3 | 蛋白磷酸酶4显性负性突变体介导的活性抑制 改善棕榈酸诱导的肝细胞脂性凋亡 | 期刊论文 | 刘进;窦琳;陈皓;马佳睿;左慧演;徐芳芷;张曦月;满永;席超;黄秀清 |
| 4 | 细胞外囊泡在非酒精脂肪肝发病机制及诊断治疗中的作用 | 期刊论文 | 杨光;窦琳;沈涛;唐蔚青;满永;黎健;黄秀清 |
| 5 | Bone marrow macrophage-derived exosomal miR-143-5p contributes to insulin resistance in hepatocytes by repressing MKP5 | 期刊论文 | Li Linfang;Zuo Huiyan;Huang Xiuqing;Shen Tao;Tang Weiqing;Zhang Xiaoyi;An Tong;Dou Lin;Li Jian |
| 6 | miR-488-3p protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting cyclinG1 | 期刊论文 | Mingjing Yan;Yuan Cao;Que Wang;Kun Xu;Lin Dou;Xiuqing Huang;Beidong Chen;Weiqing Tang;Ming Lan;Bing Liu;Kaiyi Zhu;Yao Yang;Shenghui Sun;Xiyue Zhang;Yong Man;Mingyan He;Tao Shen;Jian Li |
| 7 | miR-154-5p Functions as an Important Regulator of Angiotensin II-Mediated Heart Remodeling | 期刊论文 | Wang Que;Yu Xiaoxue;Dou Lin;Huang Xiuqing;Zhu Kaiyi;Guo Jun;Yan Mingling;Wang Siming;Man Yong;Tang Weiqing;Shen Tao;Li Jian |
| 8 | GPR120 facilitates cholesterol efflux in macrophages through activation of AMPK signaling pathway | 期刊论文 | Tong An;Xiaoyi Zhang;Hongxia Li;Lin Dou;Xiuqing Huang;Yong Man;Xiyue Zhang;Tao Shen;Guoping Li;Jian Li;Weiqing Tang |
| 9 | Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in Hepatocytes | 期刊论文 | Hao Chen;Jiarui Ma;Jin Liu;Lin Dou;Tao Shen;Huiyan Zuo;Fangzhi Xu;Li Zhao;Weiqing Tang;Yong Man;Yanyan Ma;Jian Li;Xiuqing Huang |
| 10 | Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes | 期刊论文 | Yu Xiaoxue;Ruan Yang;Huang Xiuqing;Dou Lin;Lan Ming;Cui Ju;Chen Beidong;Gong Huan;Wang Que;Yan Mingjing;Sun Shenghui;Qiu Quan;Zhang Xiyue;Man Yong;Tang Weiqing;Li Jian;Shen Tao |
| 11 | Cardiac Aging: From Basic Research to Therapeutics | 期刊论文 | Yan Mingjing;Sun Shenghui;Xu Kun;Huang Xiuqing;Dou Lin;Pang Jing;Tang Weiqing;Shen Tao;Li Jian |
| 12 | miR-23a/b-3p promotes hepatic lipid accumulation by regulating srebp-1c and fas | 期刊论文 | Linfang Li;Xiaoyi Zhang;Hangjiang Ren;Xiuqing Huang;Tao Shen;Weiqing Tang;Lin Dou;Jian Li |
| 13 | Protein Phosphatase 4 Promotes Hepatocyte Lipoapoptosis by Regulating RAC1/MLK3/JNK Pathway | 期刊论文 | Huang Xiuqing;Yang Guang;Zhao Li;Yuan Huiping;Chen Hao;Shen Tao;Tang Weiqing;Man Yong;Ma Jiarui;Ma Yanyan;Dou Lin;Li Jian |
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