肿瘤突变负荷估测模型的建立及其在免疫检查点抑制剂疗效预测中的临床应用
81871889
2018
H1818.肿瘤免疫治疗
王志杰
面上项目
主任医师
中国医学科学院肿瘤医院
58万元
肺肿瘤
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | EPHA mutation as a predictor of immunotherapeutic efficacy in lung adenocarcinoma | 期刊论文 | Hua Bai;Jianchun Duan;Chengcheng Li;Wenzhuan Xie;Wenfeng Fang;Yu Xu;Guoqiang Wang;Rui Wan;Jing Sun;Jiachen Xu;Xin Wang;Kailun Fei;Zhengyi Zhao;Shangli Cai;Li Zhang;Jie Wang;Zhijie Wang |
| 2 | Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC | 期刊论文 | Yiting Sun;Jianchun Duan;Wenfeng Fang;Zhijie Wang;Xinyang Du;Xin Wang;Chengcheng Li;Shangli Cai;Jie Zhao;Sini Li;Li Zhang;Hua Bai;Jie Wang |
| 3 | Toripalimab Plus Chemotherapy for Patients With Treatment-Naive Advanced Non– Small-Cell Lung Cancer: A Multicenter Randomized Phase III Trial (CHOICE-01) | 期刊论文 | Zhijie Wang;Lin Wu;Baolan Li;Ying Cheng;Xiaoling Li;Xicheng Wang;Liang Han;Xiaohong Wu;Yun Fan;Yan Yu;Dongqing Lv;Jianhua Shi;Jianjin Huang;Shaozhang Zhou;Baohui Han;Guogui Sun;Qisen Guo;Youxin Ji;Xiaoli Zhu;Sheng Hu;Wei Zhang;Qiming Wang;Yuming Jia;Ziping Wang;Yong Song;Jingxun Wu;Meiqi Shi;Xingya Li;Zhigang Han;Yunpeng Liu;Zhuang Yu;An-Wen Liu;Xiuwen Wang;Caicun Zhou;Diansheng Zhong;Liyun Miao;Zhihong Zhang... |
| 4 | Allele frequency-adjusted blood-based tumor mutational burden as a predictor of overall survival for non-small cell lung cancer patients treated with PD-1/PD-L1 inhibitors | 期刊论文 | Zhijie Wang;Jianchun Duan;Guoqiang Wang;Jing Zhao;Jiachen Xu;Jiefei Han;Zhengyi Zhao;Jun Zhao;Bo Zhu;Minglei Zhuo;Jianguo Sun;Hua Bai;Rui Wan;Xin Wang;Kailun Fei;Shuhang Wang;Xiaochen Zhao;Yuzi Zhang;Mengli Huang;Depei Huang;Chuang Qi;Chan Gao;Yuezong Bai;Hua Dong;Lei Xiong;Yanhua Tian;Di Wang;Chunwei Xu;Wenxian Wang;Junling Li;Xingsheng Hu;Shangli Cai;Jie Wang |
| 5 | PAPPA2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non-small cell lung cancer. | 期刊论文 | Yiting Dong;Lele Zhao;Jianchun Duan;Hua Bai;Dongsheng Chen;Si Li;Yangyang Yu;Mingzhe Xiao;Qin Zhang;Qianqian Duan;Tingting Sun;Chuang Qi;Jie Wang;Zhijie Wang |
| 6 | The Feasibility of Using Biomarkers Derived from Circulating Tumor DNA Sequencing as Predictive Classifiers in Patients with Small-Cell Lung Cancer | 期刊论文 | Yu Feng;Yutao Liu;Mingming Yuan;Guilan Dong;Hongxia Zhang;Tongmei Zhang;Lianpeng Chang;Xuefeng Xia;Lifeng Li;Haohua Zhu;Puyuan Xing;Hongyu Wang;Yuankai Shi;Zhijie Wang;Xingsheng Hu |
| 7 | Safety, Antitumor Activity, and Pharmacokinetics of Toripalimab, a Programmed Cell Death 1 Inhibitor, in Patients With Advanced Non-Small Cell Lung Cancer A Phase 1 Trial | 期刊论文 | Zhijie Wang;Jianming Ying;Jiachen Xu;Pei Yu;Jianchun Duan;Hua Bai;Changyuan Guo;Lin Li;Zhenlin Yang;Rui Wan;Kailun Fei;Zhe Zhao;Xinyang Du;Junhui Zhao;Ning Lv;Jie Wang |
| 8 | Biophysical heterogeneity of myeloid-derived microenvironment to regulate resistance to cancer immunotherapy | 期刊论文 | 赵杰;董依廷;张筠笛;王洁;王志杰 |
| 9 | A novel tumor mutational burden estimation model as a predictive and prognostic biomarker in NSCLC patients | 期刊论文 | Yanhua Tian;Jiachen Xu;Qian Chu;Jianchun Dua;Jianjun Zhang;Hua Bai;Zhenlin Yang;Wenfeng Fang;Liangliang Cai;Rui Wan;Kailun Fei;Jie He;Shugeng Gao;Li Zhang;Zhijie Wang;Jie Wang |
| 10 | TGFBR2 mutation predicts resistance to immune checkpoint inhibitors in patients with non-small cell lung cancer | 期刊论文 | Teng Li;Han Wang;Jiachen Xu;Chengcheng Li;Yudong Zhang;Guoqiang Wang;Yutao Liu;Shangli Cai;Wenfeng Fang;Junling Li;Zhijie Wang |
| 11 | 肺腺癌预后标志物的应用 | 专利 | 王洁;王志杰;张筠笛;徐佳晨;白桦;段建春 |
| 12 | 模型及构建方法、处理方法及装置、储存介质、电子设备 | 专利 | 王志杰;王洁;费凯伦;段建春;白桦 |
| 13 | Maximum Somatic Allele Frequency-Adjusted Blood-Based Tumor Mutational Burden Predicts the Efficacy of Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer | 期刊论文 | Yiting Dong;Yixiang Zhu;Minglei Zhuo;Xiaomin Chen;Yinpeng Xie;Jianchun Duan;Hua Bai;Shiguang Hao;Zicheng Yu;Yuting Yi;Yanfang Guan;Jie Yuan;Xuefeng Xia;Xin Yi;Jie Wang;Zhijie Wang |
| 14 | 基于外周血分子分型的肺癌个体化诊疗体系建立及临床推广应用 | 奖励 | 王洁;王志杰;高亦博;赵军;白凡;阮力;白桦;高燕宁;段建春;赫捷;陈克能;朱冠山;李峻岭;卓明磊;王书航 |
| 15 | Assessment of Blood Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Patients With Non–Small Cell Lung Cancer With Use of a Next-Generation Sequencing Cancer Gene Panel | 期刊论文 | Zhijie Wang;Jianchun Duan;Shangli Cai;Miao Han;Hua Dong;Jun Zhao;Bo Zhu;Shuhang Wang;Minglei Zhuo;Jianguo Sun;Qiming Wang;Hua Bai;Jiefei Han;Yanhua Tian;Jing Lu;Tongfu Xu;Xiaochen Zhao;Guoqiang Wang;Xinkai Cao;Fugen Li;Dalei Wang;Yuejun Chen;Yuezong Bai;Jing Zhao;Zhengyi Zhao;Yuzi Zhang;Lei Xiong;Jie He;Shugeng Gao;Jie Wang |
| 16 | 基于HLA-I 抗原呈递能力的免疫治疗评估方法及装置 | 专利 | 王志杰;王洁;韩解非;董依廷;白桦;段建春 |
| 17 | Blockade of STAT3/IL-4 overcomes EGFR T790M-cis-L792F-induced resistance to osimertinib via suppressing M2 macrophages polarization | 期刊论文 | Yiting Sun;Yiting Dong;Xiao-Qing Liu;Yundi Zhang;Hua Bai;Jianchun Duan;Zhihua Tian;Xiang Yan;Jie Wang;Zhijie Wang |
| 18 | 基于外周血分子分型的肺癌个体化诊疗体系建立及临床推广应用 | 奖励 | 王洁;王绿化;王志杰;毕楠;陈克能;白桦;白凡;高亦博;段建春;阮力 |
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