DNA修复通路基因复合突变对遗传性乳腺癌-卵巢癌综合征中表型扩展的作用与机制研究
81802669
2018
H1804.肿瘤遗传与进化
刘嘉琦
青年科学基金项目
副主任医师
中国医学科学院肿瘤医院
21万元
DNA修复通路;复合突变模型;CRISPR/Cas9基因编辑系统;遗传性乳腺癌-卵巢癌综合征;表型扩展
2019-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 50例中国男性乳腺癌临床特征和遗传学病因 | 期刊论文 | 秦岭;邢泽宇;刘嘉琦;钱天一;王畅畅;王昕;王翔 |
| 2 | Genome-wide cell-free DNA methylation analyses improve accuracy of non-invasive diagnostic imaging for early-stage breast cancer. | 期刊论文 | Liu Jiaqi;Zhao Hengqiang;Huang Yukuan;Xu Shouping;Zhou Yan;Zhang Wei;Li Jiaqi;Ming Yue;Wang Xinyu;Zhao Sen;Li Kai;Dong Xiying;Ma Yunlong;Qian Tianyi;Chen Xinyi;Xing Zeyu;Zhang Yan;Chen Hongyan;Liu Zhihua;Pang Da;Zhou Meng;Wu Zhihong;Wang Xiaowo;Wang Xiang;Wu Nan;Su Jianzhong |
| 3 | Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer. | 期刊论文 | Wang Xin;Qian Tianyi;Bao Siqi;Zhao Hengqiang;Chen Hongyan;Xing Zeyu;Li Yalun;Zhang Menglu;Meng Xiangzhi;Wang Changchang;Wang Jie;Gao Hongxia;Liu Jiaqi;Zhou Meng;Wang Xiang |
| 4 | 一种乳腺癌患者携带胚系致病变异的风险预测系统 | 专利 | 刘嘉琦;郑羽;吴南;苏建忠;杨永鑫;赵恒强;吴志宏;范燃;郑思思;陈泽根 |
| 5 | 乳腺颗粒细胞瘤1例并文献回顾 | 期刊论文 | 冯轲昕;杨召阳;刘嘉琦;邢泽宇;刘刚;张宏图;王翔 |
| 6 | Decreased level of peripheral CD8(+)CD28(+)T cells is associated with lymph node metastasis in patients with breast cancer | 期刊论文 | Li Yalun;Qian Tianyi;Zhao Hengqiang;Zhang Zhen;Ming Yue;Qiao Guangdong;Liu Jiaqi |
| 7 | Genomic instability-derived plasma extracellular vesicle-microRNA signature as a minimally invasive predictor of risk and unfavorable prognosis in breast cancer. | 期刊论文 | Bao Siqi;Hu Ting;Liu Jiaqi;Su Jianzhong;Sun Jie;Ming Yue;Li Jiaxin;Wu Nan;Chen Hongyan;Zhou Meng |
| 8 | Progress and Future Trends in PET/CT and PET/MRI Molecular Imaging Approaches for Breast Cancer | 期刊论文 | Yue Ming;Nan Wu;Tianyi Qian;Xiao Li;David Q. Wan;Caiying Li;Yalun Li;Zhihong Wu;Xiang Wang;Jiaqi Liu;Ning Wu |
| 9 | Breast-conserving therapy is safe both within BRCA1/2 mutation carriers and noncarriers with breast cancer in the Chinese population | 期刊论文 | Huang Xin;Cai Xiu-Yu;Liu Jia-Qi;Hao Wen-Wen;Zhou Yi-Dong;Wang Xiang;Xu Ying;Chen Chang;Lin Yan;Wang Chang-Jun;Song Yu;Sun Qiang |
| 10 | 乳腺癌患者的生育力保护及保存 | 期刊论文 | 刘嘉琦;齐立强 |
| 11 | The Distinct Performances of Ultrasound, Mammograms, and MRI in Detecting Breast Cancer in Patients With Germline Pathogenic Variants in Cancer Predisposition Genes. | 期刊论文 | Liu Jiaqi;Wang Xin;Dong Lin;Huang Xin;Zhao Hengqiang;Li Jiaxin;Huang Shengkai;Yuan Pei;Wang Wenyan;Wang Jie;Xing Zeyu;Jia Ziqi;Ming Yue;Li Xiao;Qin Ling;Liu Gang;Wu Jiang;Li Yiqun;Zhang Menglu;Feng Kexin;Ying Jianming;Wang Xiang |
| 12 | Mutational landscape and genetic signatures of cell-free DNA in tumour-induced osteomalacia | 期刊论文 | Wu Nan;Zhang Zhen;Zhou Xi;Zhao Hengqiang;Ming Yue;Wu Xue;Zhang Xian;Yang Xin-Zhuang;Zhou Meng;Bao Hua;Chen Weisheng;Wu Yong;Liu Sen;Wang Huizi;Niu Yuchen;Li Yalun;Zheng Yu;Shao Yang;Gao Na;Yang Ying;Liu Ying;Li Wenli;Liu Jia;Zhang Na;Yang Xu;Xu Yuan;Li Mei;Sun Yingli;Su Jianzhong;Zhang Jianguo;Xia Weibo;Qiu Guixing;Liu Yong;Liu Jiaqi;Wu Zhihong |
| 13 | DrABC: Deep Learning Accurately Predicts Germline Pathogenic Mutation Status in Breast Cancer Patients Based on Phenotype Data | 期刊论文 | Jiaqi Liu;Hengqiang Zhao;Yu Zheng;Lin Dong;Sen Zhao;Yukuan Huang;Shengkai Huang;Tianyi Qian;Jiali Zou;Shu Liu;Jun Li;Zihui Yan;Yalun Li;Shuo Zhang;Xin Huang;Wenyan Wang;Yiqun Li;Jie Wang;Yue Ming;Xiaoxin Li;Zeyu Xing;Ling Qin;Zhengye Zhao;Ziqi Jia;Jiaxin Li;Gang Liu;Menglu Zhang;Kexin Feng;Jiang Wu;Jianguo Zhang;Yongxin Yang;Zhihong Wu;Zhihua Liu;Jianming Ying;Xin Wang;Jianzhong Su;Xiang Wang;Nan Wu |
| 14 | Contralateral risk-reducing local therapy in breast cancer patients with BRCA1/2 mutations: systemic review and meta-analysis. | 期刊论文 | Jia Ziqi;Li Jiaxin;Zhang Yuelun;Wang Xin;Xing Jiahua;Xing Zeyu;Huang Xin;Liu Gang;Zhang Menglu;Feng Kexin;Wu Jiang;Wang Wenyan;Wang Jie;Liu Jiaqi;Wang Xiang |
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