天然产物独特结构单元的生物合成机制研究

20832009
2008
B0111.仿生与绿色合成
刘文
重点项目
研究员
中国科学院上海有机化学研究所
200万元
生物合成;结构基因;独特结构单元;天然产物;组合生物合成
2009-01-01到2012-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Analysis of YM-216391 biosynthetic gene cluster and improvement of the cyclopeptide production in a heterologous host 期刊论文 Jian Xiaohong|Pan Haixue|Ning Tingting|Shi Yuanyuan|Li Yan|Zeng Xiaowei|Xu Jian|Tang, Gongli|
2 Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS 期刊论文 Zhang, Qi|van der Donk, Wilfred A.|Liu, Wen|
3 Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications 期刊论文 Liao, Rijing|Liu, Wen|Duan, Lian|Lei, Chun|Pan, Haixue|Ding, Ying|Zhang, Qi|Chen, Daijie|Shen, Ben|Yu, Yi|
4 Thiostrepton Maturation Involving a Deesterification-Amidation Way To Process the C-Terminally Methylated Peptide Backbone 期刊论文 Liao, Rijing|Liu, Wen|
5 Alternative epimerization inC7N-aminocyclitol biosynthesis is catalyzed by ValD, a large protein of thevicinal oxygen chelate superfamily 期刊论文 Hui Xu|Yirong Zhang|Jongtae Yang|Taifo Mahmud|Linquan Bai|Zixin Deng|
6 Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B. 期刊论文 Wei Ding|Wei Deng|Mancheng Tang|Qi Zhang|Gongli Tang|Yurong Bi|Wen Liu|
7 In vivo investigation of the role of SfmO2 in saframycin A biosynthesis by structural characterization of the analogue saframycin O 期刊论文 Peng Chao|Tang Yunmin|Li Lei|Ding Wei|Deng Wei|Pu Jinyue|Liu, Wen|Tang, Gongli|
8 Insights into Bacterial 6-Methylsalicylic Acid Synthase and Its Engineering to Orsellinic Acid Synthase for Spirotetronate Generation 期刊论文 Wei Ding|Chun Lei|Qingli He|Qinglin Zhang|Yurong Bi|Wen Liu|
9 Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics 期刊论文 Lipeng Zhai|Shuangjun Lin|Dongjing Qu|Xuechuan Hong|Linquan Bai|Wenqing Chen|Zixin Deng|
10 抗肿瘤活性四氢异喹啉抗生素的生物合成研究进展 期刊论文 唐满成|唐功利|
11 Dual Carbamoylations on the Polyketide and Glycosyl Moiety by Asm21 Result in Extended Ansamitocin Biosynthesis 期刊论文 Yan Li|Peiji Zhao|Qianjin Kang|Juan Ma|Linquan Bai|Zixin Deng|
12 Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor 期刊论文 Qu, Xudong|Jiang, Nan|Xu, Fei|Shao, Lei|Tang, Gongli|Wilkinson, Barrie|Liu, Wen|
13 Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis 期刊论文 Jongtae Yang|Hui Xu|Yirong Zhang|Linquan Bai|Zixin Deng|Taifo Mahmud|
14 Structural and Functional Analysis of Validoxylamine A 79-phosphate Synthase ValL Involved in Validamycin A Biosynthesis 期刊论文 Lina Zheng|Xiang Zhou|Huaidong Zhang|Xiaofeng Ji|Lei Li|Lin Huang|Linquan Bai|Houjin Zhang|
15 Self-resistance to antitumor antibiotic: a DNA glycosylase triggers the base excision repair system in yatakemycin biosynthesis. 期刊论文 Xu Hui|Huang Wei|He Qingli|Zhao Zhixiong|Zhang Feng|Wang Renxiao|Kang Jingwu|Tang, Gongli|
16 Insights into Pyrroindomycin Biosynthesis Reveal a Uniform Paradigm for Tetramate/Tetronate Formation 期刊论文 Qiongqiong Wu|Zhuhua Wu|Xudong Qu|Wen Liu|
17 ThioFinder: A Web-Based Tool for the Identification of Thiopeptide Gene Clusters in DNA Sequences 期刊论文 Jing Li|Xudong Qu|Xinyi He|Lian Duan|Guojun Wu|Dexi Bi|Zixin Deng|Wen Liu|Hong- Yu Ou|
18 Characterization of the Polyoxin Biosynthetic Gene Cluster from Streptomyces cacaoi and Engineered Production of Polyoxin H 期刊论文 Wenqing Chen|Huchen Zhou|Xiufen Zhou|Huarong Tan|Zixin Deng|Tingting Huang|Xinyi He|Qingqing Meng|Delin You|Linquan Bai|Jialiang Li|Mingxuan Wu|Rui Li|
19 Functional characterization of the first twoactinomycete 4-amino-4-deoxychorismate lyase genes. 期刊论文 Yirong Zhang|Linquan Bai|Zixin Deng|
20 NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide 期刊论文 Yu, Yi|Guo, Heng|Zhang, Qi|Duan, Lian|Ding, Ying|Liao, Rijing|Lei, Chun|Shen, Ben|Liu, Wen|
21 Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units 期刊论文 Zhang Feng|He Haiyan|Tang Mancheng|Tang Yumin|Zhou Qiang|Tang Gongli|
22 Quartromicin biosynthesis: two alternative polyketide chains produced by one polyketide synthase assembly line 期刊论文 He Haiyan|Pan Haixue|Wu Longfei|Zhang Beibei|Chai Hanbo|Liu Wen|Tang Gongli|
23 Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework 期刊论文 Yu, Yi|Liu, Wen|Duan, Lian|Zhang, Qi|Liao, Rijing|Ding, Ying|Pan, Haixue|Wendt-Pienkowski, Evelyn|Tang, Gongli|Shen, Ben|
24 Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS 期刊论文 Yingying Wu|Qianjin Kang|Yuemao Shen|Wenjin Su|Linquan Bai|
25 Identification of phoslactomycin biosynthetic gene clusters from Streptomyces platensis SAM-0654 and characterization of PnR1 and PnR2 as positive transcriptional regulators. 期刊论文 Chen Yunliang|Zhao Juan|Liu wei|Gao Junfang|Tao Liming|Pan, Haixue|Tang Gongli|
26 Cloning of Separate Meilingmycin Biosynthesis Gene Clusters by Use of Acyltransferase-Ketoreductase Didomain PCR Amplification 期刊论文 Yunlong He|Yuhui Sun|Tiangang Liu|Xiufen Zhou|Linquan Bai|Zixin Deng|
27 Characterization of the Biosynthesis Gene Cluster for the Pyrrole Polyether Antibiotic Calcimycin (A23187) in Streptomyces chartreusis NRRL 3882 期刊论文 Qiulin Wu|Jingdan Liang|Shuangjun Lin|Xiufen Zhou|Linquan Bai|Zixin Deng|Zhijun Wang|
28 Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems 期刊论文 Chen, Dandan|Zhang, Qi|Zhang, Qinglin|Cen, Peilin|Xu, Zhinan|Liu, Wen|
29 Cloning and Characterization of the Polyether Salinomycin Biosynthesis Gene Cluster of Streptomyces albus XM211 期刊论文 Chunyan Jiang|Hougen Wang|Qianjin Kang|Jing Liu|Linquan Bai|
30 Transcriptome Mining of Active Biosynthetic Pathways and Their Associated Products in Streptomyces flaveolus 期刊论文 Qu, Xudong|Lei, Chun|Liu, Wen|
31 Biosynthesis of 3,5-AHBA-derived natural products 期刊论文 Qianjin Kang|Yuemao Shen|Linquan Bai|
32 Radical-mediated enzymatic carbon chain fragmentation-recombination 期刊论文 Zhang, Qi|Li, Yuxue|Chen, Dandan|Yu, Yi|Duan, Lian|Shen, Ben|Liu, Wen|
33 Toward steadfast growth of antibiotic research in China: From natural products to engineered biosynthesis 期刊论文 Qianjin Kang|Linquan Bai|Zixin Deng|
34 Genetically engineered production of 1,1′-bis-valienamine and validienamycin in Streptomyces hygroscopicus and their conversion to valienamine 期刊论文 Hui Xu|Jongtae Yang|Linquan Bai|Zixin Deng|Taifo Mahmud|
35 NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide 期刊论文 Yu, Yi|Guo, Heng|Zhang, Qi|Duan, Lian|Ding, Ying|Liao, Rijing|Lei, Chun|Shen, Ben|Liu, Wen|
36 Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS 期刊论文 Yingying Wu|Qianjin Kang|Yuemao Shen|Wenjin Su|Linquan Bai|
37 Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems 期刊论文 Chen, Dandan|Zhang, Qi|Zhang, Qinglin|Cen, Peilin|Xu, Zhinan|Liu, Wen|
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