识别核仁素的G-四链体探针的构建与识别机理研究
21375135
2013
B0406.生命与公共安全分析
上官棣华
面上项目
研究员
中国科学院化学研究所
80万元
核仁素;药物发现;G-四链体;分子识别;分子探针
2014-01-01到2017-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Dicyanomethylene-Functionalized Squaraine as a Highly Selective Probe for Parallel G-Quadruplexes | 期刊论文 | Jin Bing;Zhang Xin;Zheng Wei;Liu Xiangjun;Zhou Jin;Zhang Nan;Wang Fuyi;Shangguan Dihua |
| 2 | N,N-二戊烷取代的喹吖啶酮类化合物及其制备方法与应用 | 专利 | 上官棣华;柳影;刘祥军;王林林 |
| 3 | HQO作为监测活细胞中线粒体自噬过程荧光探针的应用 | 专利 | 上官棣华;柳影;周进;王林林;刘祥军 |
| 4 | 2,9-双甲基苯并噻唑乙烯基邻菲咯啉与DNA的相互作用及应用研究 | 期刊论文 | 常昂;刘祥军;吴尚荣;柳影;王林林;张楠;李松青;上官棣华 |
| 5 | Effects of side chains on DNA binding, cell permeability, nuclear localization and cytotoxicity of 4-aminonaphthalimides | 期刊论文 | Zhou Jin;Chang Ang;Wang Linlin;Liu Ying;Liu Xiangjun;Shangguan Dihua |
| 6 | Activity enhancement of G-quadruplex/hemin DNAzyme by spermine | 期刊论文 | Qi Cui;Zhang Nan;Yan Jingli;Liu Xiangjun;Bing Tao;Mei Hongcheng;Shangguan Dihua |
| 7 | Flow cytometric bead sandwich assay based on a split aptamer | 期刊论文 | Luyao Shen;Tao Bing;Xiangjun Liu;Junyan Wang;Linlin Wang;Nan Zhang;Dihua Shangguan |
| 8 | Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides | 期刊论文 | Zhang Nan;Bing Tao;Liu Xiangjun;Qi Cui;Shen Luyao;Wang Linlin;Shangguan Dihua |
| 9 | 核酸适配体在识别并结合整合素α4中的应用 | 专利 | 上官棣华;邴涛;汪寅生;刘祥军 |
| 10 | 2,9-双苯乙烯取代的邻菲罗啉类化合物及其制备方法与应用 | 专利 | 上官棣华;刘祥军;吴尚荣;王林林 |
| 11 | 一种识别并结合人转铁蛋白受体的核酸适体序列及其应用 | 专利 | 上官棣华;张楠;邴涛;刘祥军;沈璐瑶 |
| 12 | 核酸适配体在识别并结合L选择素中的应用 | 专利 | 上官棣华;邴涛;汪寅生;刘祥军 |
| 13 | A Bis-methylpiperazin-styryl Phenanthroline as a FluorescentLigand for G-Quadruplexes | 期刊论文 | Wu Shangrong;Wang Linlin;Zhang Nan;Liu Ying;Zheng Wei;Chang Ang;Wang Fuyi;Li Songqin;Shangguan Dihua |
| 14 | 基于新铜试剂的Cu2+荧光探针的合成及性能研究 | 期刊论文 | 常昂;吴尚荣;柳影;张鑫;魏涌标;李松青;刘祥军;上官棣华 |
| 15 | Activity Enhancement of G-Quadruplex/Hemin DNAzyme by Flanking d(CCC) | 期刊论文 | Chang Tianjun;Gong Hongmei;Ding Pi;Liu Xiangjun;Li Weiguo;Bing Tao;Cao Zehui;Shangguan Dihua |
| 16 | Interaction of bisbenzimidazole-substituted carbazole derivatives with G-quadruplexes and living cells | 期刊论文 | Wei Yongbiao;Zhang Xin;Wang Linlin;Liu Ying;Bing Tao;Liu Xiangjun;Shangguan Dihua |
| 17 | Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes | 期刊论文 | Zhang Xin;Jin Bing;Zheng Wei;Zhang Nan;Liu Xiangjun;Bing Tao;Wei Yongbiao;Wang Fuyi;Shangguan Dihua |
| 18 | DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives | 期刊论文 | Liu Ying;Wang Linlin;Zhou Jin;Wu Shangrong;Wei Yongbiao;Chang Ang;Liu Xiangjun;Shangguan Dihua |
| 19 | Detection of G-Quadruplex Structures Formed by G-Rich Sequences from Rice Genome and Transcriptome Using Combined Probes | 期刊论文 | Chang Tianjun;Li Weiguo;Ding Zhan;Cheng Shaofei;Liang Kun;Liu Xiangjun;Bin Tao;Shangguan Dihua |
| 20 | Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo | 期刊论文 | Wei Yongbiao;Hu Xiaoxiao;Shen Luyao;Jin Bing;Liu Xiangjun;Tan Weihong;Shangguan Dihua |
| 21 | 一种识别耐阿霉素乳腺癌细胞的核酸适体及其筛选方法和应用 | 专利 | 上官棣华;张楠;邴涛;刘祥军 |
| 22 | Facile Phase Transfer and Surface Biofunctionalization of Hydrophobic Nanoparticles Using Janus DNA Tetrahedron Nanostructures | 期刊论文 | Li Juan;Hong Cheng-Yi;Wu Shu-Xian;Liang Hong;Wang Li-Ping;Huang Guoming;Chen Xian;Yang Huang-Hao;Shangguan Dihua;Tan Weihong |
| 23 | Ratiometric fluorescent silver nanoclusters for the determination of mercury and copper ions | 期刊论文 | Liu Xiangjun;Wang Linlin;Zhang Nan;Shangguan Dihua |
| 24 | Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo | 期刊论文 | Liu Ying;Hu Xiaoxiao;Wang Linlin;Liu Xiangjun;Bing Tao;Tan Weihong;Shangguan Dihua |
| 25 | Fluorescence Light-Up Probe for Parallel G-Quadruplexes | 期刊论文 | Jin Bing;Zhang Xin;Zheng Wei;Liu Xiangjun;Qi Cui;Wang Fuyi;Shangguan Dihua |
| 26 | Visible-light-induced cleavage of 4-alpha-amino acid substituted naphthalimides and its application in DNA photocleavage | 期刊论文 | Zhou Jin;Fang Canliang;Liu Ying;Zhao Yao;Zhang Nan;Liu Xiangjun;Wang Fuyi;Shangguan Dihua |
| 27 | Facile Discovery of Cell-Surface Protein Targets of Cancer Cell Aptamers | 期刊论文 | Bing Tao;Shangguan Dihua;Wang Yinsheng |
| 28 | 一种不对称菁染料及其与不同结构DNA的相互作用 | 期刊论文 | 吴尚荣;金冰;张楠;柳影;刘祥军;李松青;上官棣华 |
| 29 | A Cyanine Dye to Probe Mitophagy: Simultaneous Detection of Mitochondria and Autolysosomes in Live Cells | 期刊论文 | Liu Ying;Zhou Jin;Wang Linlin;Hu Xiaoxiao;Liu Xiangjun;Liu Meirong;Cao Zehui;Shangguan Dihua;Tan Weihong |
| 30 | Microbead-Based Platform for Multiplex Detection of DNA and Protein | 期刊论文 | Liu Xiangjun;Bing Tao;Shangguan Dihua |
| 31 | 面向活细胞分析的分子探针的构建及应用研究 | 奖励 | 上官棣华;常天俊;张楠;刘祥军;邴涛;柳影;金冰;周进;魏涌标;张鑫;吴尚荣 |
| 32 | Intercellular ConnectionsRelated to Cell–Cell Crosstalk Specifically Recognized by an Aptamer | 期刊论文 | Zhang Nan;Bing Tao;Shen，Luyao;Song，Rusheng;Wang Linlin;Liu Xiangjun;Liu Meirong;Li Juan;Tan Weihong;Shangguan Dihua |
| 33 | Triplex-quadruplex structural scaffold: a new binding structure of aptamer | 期刊论文 | Bing Tao;Zheng Wei;Zhang Xin;Shen Luyao;Liu Xiangjun;Wang Fuyi;Cui Jie;Cao Zehui;Shangguan Dihua |
| 34 | Development of squaraine based G-quadruplex ligands using click chemistry | 期刊论文 | Zhang Xin;Wei Yongbiao;Bing Tao;Liu Xiangjun;Zhang Nan;Wang Junyan;He Junqing;Jin Bing;Shangguan Dihua |
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