TIMP-2对阿尔茨海默病血脑屏障损伤的保护作用及机制研究

81872855
2018
H3501.神经精神药物药理
彭英
面上项目
研究员
中国医学科学院药物研究所
57万元
阿尔茨海默病;组织基质金属蛋白酶抑制剂;血脑屏障;基质金属蛋白酶2
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 TIMP2在制备预防或治疗创伤性脑损伤药物中的应用 专利 彭英;唐婧姝;康钰莹;兰嘉琦
2 A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro 期刊论文 Yong Zhang;Yu-Jun Zhou;Jing-Shu Tang;Jia-Qi Lan;Yu-Ying Kang;Lei Wu;Ying Peng
3 靶向E3泛素连接酶的药物研究进展 期刊论文 商廿颍;赵春阳;彭英
4 Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of Amyotrophic lateral sclerosis. 期刊论文 Zhou Yujun;Tang Jingshu;Lan Jiaqi;Zhang Yong;Wang Hongyue;Chen Qiuyu;Kang Yuying;Sun Yang;Feng Xinhong;Wu Lei;Jin Hongtao;Chen Shizhong;Peng Ying
5 ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis 期刊论文 Jingshu Tang;Yuying Kang;Yujun Zhou;Xinnan Li;Jiaqi Lan;Lei Wu;Xinhong Feng;Ying Peng
6 TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin beta 1 complex and regulating downstream FAK/RhoA signaling 期刊论文 Jingshu Tang;Yuying Kang;Longjian Huang;Lei Wu;Ying Peng
7 Neuroprotective effects of Hemocoagulase Agkistrodon on experimental traumatic brain injury 期刊论文 Jingshu Tang;Yuying Kang;Longjian Huang;Xinhong Feng;Lei Wu;Ying Peng
8 L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer's disease mouse model and cultured hippocampal neurons 期刊论文 Huang Longjian;Lan Jiaqi;Tang Jingshu;Kang Yuying;Feng Xinhong;Wu Lei;Peng Ying
9 Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Protein-Protein Interaction. 期刊论文 Yong Zhang;Zeyu Shi;Yujun Zhou;Qiong Xiao;Hongyue Wang;Ying Peng
10 The MMP-2/TIMP-2 system in Alzheimer disease. 期刊论文 Wang Hongyue;Huang Longjian;Wu Lei;Lan Jiaqi;Feng Xinhong;Li Pingping;Peng Ying
11 Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases 期刊论文 Xinnan Li;Longjian Huang;Jiaqi Lan;Xinhong Feng;Pingping Li;Lei Wu;Ying Peng
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