TRIP-Br2对内脏白色脂肪棕色化抵抗的影响及机制研究
81770847
2017
H0709.能量代谢调节异常与肥胖
强桂芬
面上项目
研究员
中国医学科学院药物研究所
53万元
肥胖;皮下脂肪;内脏脂肪;TRIP-Br2;白色脂肪棕色化
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 黄芩素在制备防治肥胖及其并发症药物中的用途 | 专利 | 杜冠华;强桂芬;何萍;侯碧玉;徐春阳;吕扬;杨秀颖;张莉;周启蒙 |
| 2 | Different lipids remodeling signature demonstrated the heterogeneity of White adipose tissue browning | 会议论文 | HE Ping;HOU Bi-yu;YANG Xiu-ying;ZHANG Li;QIANG Gui-fen;DU Guan-hua |
| 3 | Chronic Urotensin-II Administration Improves Whole-Body Glucose Tolerance in High-Fat Diet-Fed Mice | 期刊论文 | Chen Xi;Yin Lin;Jia Wei-hua;Wang Nuo-qi;Xu Chun-yang;Hou Bi-yu;Li Na;Zhang Li;Qiang Gui-fen;Yang Xiu-ying;Du Guan-hua |
| 4 | 一种多肽在制备预防或治疗代谢综合征药物中的用途 | 专利 | 杜冠华;杨秀颖;陈熙;陈柏年;强桂芬;张莉;贾伟华;殷琳 |
| 5 | 化合物palosuran防治骨骼肌萎缩等疾病的用途 | 专利 | 杜冠华;杨秀颖;陈熙;强桂芬;殷琳;贾伟华;王诺琪;张莉;侯碧玉 |
| 6 | Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue | 期刊论文 | Hou Bi-yu;Zhao Yan;He Ping;Xu Chun-yang;Ma Peng;Lam Sin Man;Li Bo-wen;Gil Victoria;Shui Guang-hou;Qiang Gui-fen;Liew Chong Wee;Du Guan-hua |
| 7 | Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice | 期刊论文 | Jia Wei-hua;Wang Nuo-qi;Yin Lin;Chen Xi;Hou Bi-yu;Wang Jin-hua;Qiang Gui-fen;Chan Chi Bun;Yang Xiu-ying;Du Guan-hua |
| 8 | 天然产物抗肥胖活性的研究进展 | 期刊论文 | 王以撒;李文兰;孙加琳;强桂芬;杜冠华 |
| 9 | 葛根素在肌肉萎缩、肌病、肌肉骨骼并发症中的用途 | 专利 | 杜冠华;杨秀颖;殷琳;强桂芬;张莉;陈熙;贾伟华;王诺琦 |
| 10 | Comprehensive Lipidome Profiling of the Kidney in Early-Stage Diabetic Nephropathy | 期刊论文 | Hou Bi-yu;He Ping;Ma Peng;Yang Xin-yu;Xu Chun-yang;Lam Sin Man;Shui Guanghou;Yang Xiuying;Zhang Li;Qiang Guifen;Du Guanhua |
| 11 | 药物共晶研究管理述评 | 会议论文 | 强桂芬;方莲花;王金华;李莉;杨秀颖;杜冠华 |
| 12 | 天然产物防治糖尿病周围神经病变的研究进展 | 期刊论文 | 徐春阳;李文兰;杨秀颖;强桂芬;杜冠华 |
| 13 | Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation | 期刊论文 | He Ping;Hou Bi-yu;Li Yan-liang;Xu Chun-yang;Ma Peng;Lam Sin Man;Gil Victoria;Yang Xin-yu;Yang Xiu-ying;Zhang Li;Shui Guang-hou;Song Jun-ke;Qiang Gui-fen;Liew Chong Wee;Du Guan-hua |
| 14 | Recent developments in natural products for white adipose tissue browning | 期刊论文 | Ma Peng;He Ping;Xu Chun-yang;Hou Bi-yu;Qiang Gui-fen;Du Guan-hua |
| 15 | Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung | 期刊论文 | Wang Zi-jing;Ma Peng;Wang Yi-sa;Hou Bi-yu;Zhou Can;Tian He;Li Bo-wen;Shui Guang-hou;Yang Xiu-ying;Qiang Gui-fen;Yin Cheng-qian;Du Guan-hua |
| 16 | 丹酚酸A防治肌肉萎缩、肌病及肌肉骨骼并发症的用途 | 专利 | 杜冠华;杨秀颖;张莉;强桂芬;贾伟华;侯碧玉;陈熙;殷琳 |
| 17 | 一种杂萜类天然药物 hypemonone A 在制备抗糖尿病药物中的应用 | 专利 | 吉腾飞;强桂芬;杜冠华;针擘;徐春阳;何萍;王佳佳 |
| 18 | Effect of skeletal muscle phenotype and gender on fasting-induced myokine expression in mice | 期刊论文 | Jia Wei-hua;Wang Nuo-qi;Yin Lin;Chen Xi;Hou Bi-yu;Qiang Gui-fen;Chan Chi Bun;Yang Xiu-ying;Du Guan-hua |
| 19 | Puerarin ameliorates skeletal muscle wasting and fiber type transformation in STZ-induced type 1 diabetic rats | 期刊论文 | Yin Lin;Chen Xi;Li Na;Jia Wei-hua;Wang Nuo-qi;Hou Bi-yu;Zhang Li;Qiang Gui-fen;Yang Xiu-ying;Du Gua-hua |
| 20 | 脂肪代谢障碍与抗炎治疗策略 | 期刊论文 | 徐春阳;李文兰;杨秀颖;强桂芬;杜冠华 |
| 21 | 抗肥胖药物靶点UCP1的基因工程细胞株和高通量药物筛选模型的建立及应用 | 专利 | 杜冠华;强桂芬;何萍;Chong Wee Liew;杨秀颖;张莉;侯碧玉;徐春阳 |
| 22 | Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-beta Signaling Pathway Activation in Tune 2 Diabetic Rats | 期刊论文 | Hou Bi-yu;Zhao Yue-rong;Qiang Gui-fen;Yang Xiu-ying;Xu Chun-yang;Chen Xi;Liu Chen-ge;Wang Xiao-bo;Zhang Li;Du Guan-hua |
| 23 | Glucose consumption assay discovers coptisine with beneficial effect on diabetic mice | 期刊论文 | Shi Li-li;Jia Wei-hua;Zhang Li;Xu Chun-yang;Chen Xi;Yin Lin;Wang Nuo-qi;Fang Lian-hua;Qiang Gui-fen;Yang Xiu-ying;Du Guan-hua |
| 24 | 探讨电镜包埋时间对脂肪组织超微结构的影响 | 期刊论文 | 曲宝清;张琪;张翠萍;何萍;强桂芬 |
| 25 | Integration of Metabolomics and Transcriptomics Reveals Ketone Body and Lipid Metabolism Disturbance Related to ER Stress in the Liver. | 期刊论文 | Ma Peng;Wang Zi-jing;Wang Yi-sa;Hou Bi-yu;Sun Jia-lin;Tian He;Li Bo-wen;Shui Guang-hou;Yang Xin-yu;Yang Xiu-ying;Qiang Gui-fen;Liew Chong Wee;Du Guan-hua |
| 26 | Hypoglycemic activity of puerarin through modulation of oxidative stress and mitochondrial function via AMPK | 期刊论文 | Hou Bi-yu;Zhao Yue-rong;Ma Peng;Xu Chun-yang;He Ping;Yang Xiu-ying;Zhang Li;Qiang Gui-fen;Du Guan-hua |
| 27 | Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2 | 期刊论文 | Xu Chun-yang;Hou Bi-yu;He Ping;Ma Peng;Yang Xin-yu;Yang Xiu-ying;Zhang Li;Qiang Gui-fen;Li Wen-lan;Du Guan-hua |
| 28 | 一种间苯三酚类化合物Hyperacmosin D及其在制备抗糖尿病药物中的应用 | 专利 | 吉腾飞;强桂芬;杜冠华;索鑫玥 |
| 29 | Lipidomics insight into chronic exposure to ambient air pollution in mice | 期刊论文 | Li Ran;Wang Yi-xuan;Hou Bi-yu;Lam Sin Man;Zhang Wen-hui;Chen Ru-cheng;Shui Guang-hou;Sun Qing-hua;Qiang Gui-feng;Liu Cui-qing |
| 30 | Toll-Like Receptor 3 Ablation Prevented High-fat Diet-induced Obesity and Metabolic Disorder. | 期刊论文 | Zhang Guo-qing;Li Ran;Li Wu;Yang Si-jia;Sun Qing;Liping Yu;Yin Hong-ping;Wang Cui;Hou Bi-yu;Wang Huan-huan;Yu L;Chen Ru-cheng;Shi Liyun;Zhang Ke-zhong;Liew Chong Wee;Qiang Gui-fen;Sun Qing-hua;Liu Cui-qing |
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