天麻活性成分20C基于Pyk2为靶点的抗帕金森病机制研究

81603316
2016
H3208.中药神经精神药理
张钊
青年科学基金项目
副研究员
中国医学科学院药物研究所
18万元
天麻活性成分;基因模型;帕金森病;多巴胺;富含脯氨酸的酪氨酸激酶
2017-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Myelin injury in the central nervous system and Alzheimer's disease 期刊论文 Wang Sha-Sha;Zhang Zhao;Zhu Tian-Bi;Chu Shi-Feng;He Wen-Bin;Chen Nai-Hong
2 RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3 beta and JNK signaling pathways in dopaminergic neuron-like cells 期刊论文 Zhang Xiao-Ling;Wang Zhen-Zhen;Shao Qian-Hang;Zhang Zhao;Li Lin;Guo Zhen-Yu;Sun Hong-Mei;Zhang Yi;Chen Nai-Hong
3 A Novel Bibenzyl Compound (20C) Protects Mice from 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine/Probenecid Toxicity by Regulating the alpha-Synuclein-Related Inflammatory Response 期刊论文 Zhang Qiu Shuang;Heng Yang;Chen Ying;Luo Piao;Wen Lu;Zhang Zhao;Yuan Yu He;Chen Nai Hong
4 RTP801 is a critical factor in the neurodegeneration process of A53T-synuclein in a mouse model of Parkinson's disease under chronic restraint stress 期刊论文 Zhang Zhao;Chu Shi-Feng;Wang Sha-Sha;Jiang Yi-Na;Gao Yan;Yang Peng-Fei;Ai Qi-Di;Chen Nai-Hong
5 The extended application of The Rat Brain in Stereotaxic Coordinates in rats of various body weight. 期刊论文 Yang Pengfei;Wang Zhenzhen;Zhang Zhao;Liu Dandan;Manolios Emmanuel Nicholas;Chen Chen;Yan Xu;Zuo Wei;Chen Naihong
6 Endoplasmic reticulum stress, an important factor in the development of Parkinson's disease 期刊论文 Mou Z;Yuan YH;Zhang Z;Song LK;Chen NH
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