以S1PR1为靶点的新型免疫抑制剂的药理学研究

81202545
2012
H3504.抗炎与免疫药物药理
金晶
青年科学基金项目
副研究员
中国医学科学院药物研究所
23万元
银屑病;多发性硬化症;自身免疫性疾病;鞘氨醇-1-磷酸1型受体激动剂;狼疮性肾炎
2013-01-01到2015-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design 期刊论文 田育林，金晶，汪小涧，扈金萍，肖琼，周琬琪，陈晓光，尹大力|
2 Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P(1)) receptor 期刊论文 Xiao Qiong|Qi Jianguo|Chen Xiaoguang|Yin Dali|
3 Design, synthsis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P) receptor 期刊论文 田育林，金晶，汪小涧，韩伟娟， 李刚，周琬琪，肖琼，齐建国，陈晓光，尹大力|
4 Development of a selective S1P(1) receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis 期刊论文 Xiao Qiong|Xue Nina|Yin Dali|Chen Xiaoguang|
5 Development of a selective S1P(1) receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis 期刊论文 Xiao Qiong|Xue Nina|Yin Dali|Chen Xiaoguang|
6 新型免疫抑制剂SYL934的抗皮肤移植排斥反应研究 期刊论文 周琬琪|扈金萍|尹大力|陈晓光|
7 新型S1P1受体激动剂Syl948抗皮肤移植排斥反应研究 期刊论文 汪小涧|周琬琪|尹大力|陈晓光|
8 Quantitative determinationof 2-amino-2-(2-(4′-(2-propyloxazol-4-yl)-[1,1′-biphenyl]-4-yl)ethyl)propane-1,3-diol and its active phosphorylated metabolite in ratblood by LC–MS/MS and application to PK/PD analysis 期刊论文 Xiaojian Wang|Jing Jin|Jinping Hu|Yan Li|
9 Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design 期刊论文 Xiao Qiong|Zhou Wanqi|Chen Xiaoguang|Yin Dali|
10 新型前药类S1P1激动剂Syl978的药理活性 期刊论文 周琬琪|薛妮娜|尹大力|陈晓光|
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