两性离子修饰的树状大分子纳米平台的构筑及其乳腺癌诊疗应用

21773026
2017
B0707.化学生物学理论、方法与技术
史向阳
面上项目
教授
东华大学
65万元
纳米金;树状大分子;纳米硫化铜;肿瘤联合治疗;肿瘤多模态成像
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Overcoming T Cell Exhaustion via Immune Checkpoint Modulation with a Dendrimer-Based Hybrid Nanocomplex 期刊论文 Gao Yue;Ouyang Zhijun;Yang Chao;Song Cong;Jiang Chunjuan;Song Shaoli;Shen Minguiu;Shi Xiangyang
2 Targeted Tumor Hypoxia Dual-Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer-Based Nanosensitizers 期刊论文 Fan Yu;Tu Wenzhi;Shen Mingwu;Chen Xuming;Ning Yuesheng;Li Junjun;Chen Tingfeng;Wang Han;Yin Fangfang;Liu Yong;Shi Xiangyang
3 一种吡啶修饰的树状大分子铜络合物杂化纳米材料的制备方法 专利 史向阳;范钰;张九龙;史梦晗;李丹;彭琛
4 一种树状大分子包裹纳米金颗粒探针及其制备和应用 专利 史向阳;陈玫秀;范钰
5 Multifunctional Dendrimer-Entrapped Gold Nanoparticles Conjugated with Doxorubicin for pH-Responsive Drug Delivery and Targeted Computed Tomography Imaging 期刊论文 Zhu J.;Wang G.;Alves C.S.;Tomás H.;Xiong Z.;Shen M.;Rodrigues J.;Shi X.
6 Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy 期刊论文 Zhang Mengen;Zhu Jingyi;Zheng Yun;Guo Rui;Wang Shige;Mignani Serge;Caminade Anne-Marie;Majoral Jean-Pierre;Shi Xiangyang
7 一种两性离子修饰的树状大分子复合材料及其制备和应用 专利 史向阳;刘晋源;熊智娟;彭琛;张九龙
8 Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Labeling and Tracking T Cells Via Dual-Modal Computed Tomography and Fluorescence Imaging. 期刊论文 Chen Meixiu;Betzer Oshra;Fan Yu;Gao Yue;Shen Mingwu;Sadan Tamar;Popovtzer Rachela;Shi Xiangyang
9 Core-shell tecto dendrimers formed: Via host-guest supramolecular assembly as pH-responsive intelligent carriers for enhanced anticancer drug delivery 期刊论文 Wang Jianhong;Li Du;Fan Yu;Shi Menghan;Yang Yunxia;Wang Le;Peng Yitian;Shen Mingwu;Shi Xiangyang
10 Dual-mode endogenous and exogenous sensitization of tumor radiotherapy through antifouling dendrimer-entrapped gold nanoparticles 期刊论文 Yang Chao;Gao Yue;Fan Yu;Cao Liu;Li Jin;Ge Yulong;Tu Wenzhi;Liu Yong;Cao Xueyan;Shi Xiangyang
11 一种基于树状大分子的放疗增敏型乏氧双模态造影剂的制备方法 专利 史向阳;涂文志;范钰;刘勇
12 一种两性离子修饰树状大分子包裹硫化铜纳米颗粒/pDNA复合物的制备方法 专利 史向阳;欧阳智俊;熊智娟;肖云超;高悦;刘仁娜
13 Antifouling Dendrimer-Entrapped Copper Sulfide Nanoparticles Enable Photoacoustic Imaging-Guided Targeted Combination Therapy of Tumors and Tumor Metastasis 期刊论文 Ouyang Zhijun;Li Du;Xiong Zhijuan;Song Cong;Gao Yue;Liu Renna;Shen Mingwu;Shi Xiangyang
14 PAMAM Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for Radiotherapy-Enhanced MR Imaging and Chemotherapy of Tumors and Tumor Metastasis 期刊论文 Yu Fan;Jiulong Zhang;Menghan Shi;Dan Li;Chunhua Lu;Xueyan Cao;Chen Peng;Serge Mignani;Jean-Pierre Majoral;Xiangyang Shi
15 Modular design of multifunctional core-shell tecto dendrimers complexed with copper(II) for MR imaging-guided chemodynamic therapy of orthotopic glioma 期刊论文 Song Cong;Ouyang Zhijun;Gao Yue;Guo Honghua;Wang Shunjuan;Wang Dayuan;Xia Jindong;Shen Mingwu;Shi Xiangyang
16 Ultrasound-enhanced fluorescence imaging and chemotherapy of multidrug-resistant tumors using multifunctional dendrimer/carbon dot nanohybrids. 期刊论文 Li Dan;Lin Lizhou;Fan Yu;Liu Long;Shen Mingwu;Wu Rong;Du Lianfang;Shi Xiangyang
17 A Dual-Responsive Platform Based on Antifouling Dendrimer-CuS Nanohybrids for Enhanced Tumor Delivery and Combination Therapy 期刊论文 Xiong Zhijuan;Wang Yue;Zhu Wei;Ouyang Zhijun;Zhu Yu;Shen Mingwu;Xia Jindong;Shi Xiangyang
18 一种包裹纳米金颗粒的两性离子和吗啡啉修饰的聚酰胺-胺树状大分子的制备方法 专利 史向阳;熊智娟;沈明武
19 Gene silencing-mediated immune checkpoint blockade for tumor therapy boosted by dendrimer-entrapped gold nanoparticles 期刊论文 Xue Xue;Li Jin;Fan Yu;Shen Mingwu;Shi Xiangyang
20 一种基于荧光碳点修饰的树状大分子的双载药靶向纳米平台的制备方法 专利 史向阳;李丹;范钰
21 Zwitterionic Gadolinium(III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis 期刊论文 Liu Jinyuan;Xiong Zhijuan;Zhang Jiulong;Peng Chen;Klajnert Maculewicz Barbara;Shen Mingwu;Shi Xiangyang
22 A multifunctional low-generation dendrimer-based nanoprobe for the targeted dual mode MR/CT imaging of orthotopic brain gliomas 期刊论文 Xu Xiaoying;Liu Kang;Wang Yue;Zhang Changchang;Shi Menghan;Wang Peng;Shen Linghong;Xia Jindong;Ye Ling;Shi Xiangyang;Shen Mingwu
23 一种叶绿素铜修饰的树状大分子铜络合物纳米诊疗材料的制备方法 专利 史向阳;范钰;朱宇
24 Dendrimer-based strategies for cancer therapy: Recent advances and future perspectives [基于树状大分子的癌症治疗策略: 最新进展和未来展望] 期刊论文 Xiong Z.;Shen M.;Shi X.
25 Design and Biomedical Applications of Poly(amidoamine) Dendrimer-Based Hybrid Nanoarchitectures 期刊论文 Fan Yu;Sun Wenjie;Shi xiangyang
26 Adoptive cellular immunotherapy of tumors via effective CpG delivery to dendritic cells using dendrimer-entrapped gold nanoparticles as a gene vector. 期刊论文 Chen Huan;Fan Yu;Hao Xinxin;Yang Chao;Peng Yucheng;Guo Rui;Shi Xiangyang;Cao Xueyan
27 Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles 期刊论文 Xu Xiaoying;Zhao Lingzhou;Li Xin;Wang Peng;Zhao Jinhua;Shi Xiangyang;Shen Mingwu
28 PAMAM Dendrimer-Based Nanodevices for Nuclear Medicine Applications 期刊论文 Xiao Tingting;Li Du;Shi Xiangyang;Shen Mingwu
29 Zwitterion-functionalized dendrimer-entrapped gold nanoparticles for serum-enhanced gene delivery to inhibit cancer cell metastasis 期刊论文 Xiong Zhijuan;Alves Carla S.;Wang Jianhua;Li Aijun;Liu Jinyuan;Shen Mingwu;Rodrigues Joao;Tomas Helena;Shi Xiangyang
30 Efficient co-delivery of microRNA 21 inhibitor and doxorubicin to cancer cells using core-shell tecto dendrimers formed via supramolecular host-guest assembly. 期刊论文 Song Cong;Xiao Yunchao;Ouyang Zhijun;Shen Mingwu;Shi Xiangyang
31 Design of dual drug-loaded dendrimer/carbon dot nanohybrids for fluorescence imaging and enhanced chemotherapy of cancer cells 期刊论文 Li Dan;Fan Yu;Shen Mingwu;Banyai Istvan;Shi Xiangyang
32 一种RGD修饰树状大分子包裹的CuS纳米颗粒的制备方法 专利 史向阳;熊智娟;沈明武
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