抗凝新药LFG的组成寡糖对内源性凝血途径选择性抑制的研究

81872774
2018
H3402.天然药物化学
吴明一
面上项目
研究员
中国科学院昆明植物研究所
57万元
糖类药物;出血倾向;寡糖;岩藻糖化糖胺聚糖;抗凝血
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Effects of native fucosylated glycosaminoglycan, its depolymerized derivatives on intrinsic factor Xase, coagulation, thrombosis, and hemorrhagic risk 期刊论文 Lutan Zhou;Na Gao;Huifang Sun;Chuang Xiao;Lian Yang;Lisha Lin;Ronghua Yin;Zi Li;Hongbin Zhang;Xu Ji;Jinhua Zhao
2 Low molecular weight glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivative thereof 专利 Jinhua Zhao;Mingyi Wu;Na Gao;Zi Li;Sensen Lai;Longyan Zhao
3 Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof 专利 Jinhua Zhao;Jinkai Liu;Mingyi Wu;Na Gao;Feng lu;Zi Li
4 A new fucosylated glycosaminoglycan containing disaccharide branches from Acaudina molpadioides: unusual structure and anti-intrinsic tenase activity 期刊论文 Hui Mao;Ying Cai;Shanni Li;Huifang Sun;Lisha Lin;Ying Pan;Wenjiao Yang;Zhicheng He;Ru Chen;Lutan Zhou;Weili Wang;Ronghua Yin;Jinhua Zhao
5 A non-anticoagulant heparin-like snail glycosaminoglycan promotes healing of diabetic wound 期刊论文 Yuebo Wu;Zhipeng Zhou;Lan Luo;Maixian Tao;Xiao Chang;Lian Yang;Xingyong Huang;Lin Hu;Mingyi Wu
6 Low molecular weight glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivative thereof 专利 Jinhua Zhao;Mingyi Wu;Na Gao;Zi Li;Sensen Lai;Longyan Zhao
7 Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments 期刊论文 Ying Cai;Wenjiao Yang;Xiaomei Li;Lutan Zhou;Zhongjuan Wang;Lisha Lin;Dingyuan Chen;Longyan Zhao;Zhongkun Li;Shubai Liu;Ronghua Yin;Zhili Zuo;Na Gao;Jinhua Zhao
8 一种抑制内源性凝血因子X酶复合物的寡糖化合物及其制备方法与用途 专利 赵金华;李振国;高娜;吴明一;陈艳明;赵龙岩;务勇圣;李姿;肖创;周剑波;许建萍;周路坦;郭亚芳;秦红波;刘吉开
9 The components and activities analysis of a novel anticoagulant candidate dHG-5 期刊论文 Huifang Sun;Na Gao;Lin Ren;Shuang Liu;Lisha Lin;Wengqi Zheng;Lutan Zhou;Ronghua Yin;Jinhua Zhao
10 Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa–Factor VIIIa Interactions 期刊论文 Chuang Xiao;Longyan Zhao;Na Gao;Mingyi Wu;Jinhua Zhao
11 NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber 期刊论文 Wenjiao Yang;Dingyuan Chen;Zhicheng He;Lutan Zhou;Ying Cai;Hui Mao;Na Gao;Zhili Zuo;Ronghua Yin;Jinhua Zhao
12 Fuc3S4S substituted oligoglycosaminoglycan and preparation method thereof 专利 Jinhua Zhao;Jinxing He;Mingyi Wu;Zhiwen Liu;Na Gao;Longyan Zhao;Zi Li;Feng Lu;Li Xu;Chuang Xiao;Lian Yang;Jun Chen;Lutan Zhou;Wenlie Peng;Jikai Liu;Zhenguo Li;Yanming Chen
13 From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors 期刊论文 Lisha Lin;Longyan Zhao;Na Gao;Ronghua Yin;Sujuan Li;Huifang Sun;Luntan Zhou;Guiling Zhao;Steven W. Purcell;Jinhua Zhao
14 Chemical synthesis and pharmacological properties of heparin pentasaccharide analogues 期刊论文 Zhipeng Zhou;Linlin Zhang;Xin Wu;Lan Luo;Jian Wu;Dan Xu;Mingyi Wu
15 Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization 期刊论文 Ru Chen;Ronghua Yin;Shanni Li;Ying Pan;Hui Mao;Ying Cai;Lisha Lin;Weili Wang;Taocui Zhang;Lutan Zhou;Na Gao;Xiaodong Luo;Jinhua Zhao
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