RELA/ LncRNA-uc002jit.1/PARP1形成环路调节DNA修复对DNA损伤药物清除白血病干细胞的影响

81872898
2018
H3505.抗肿瘤药物药理
吴丽贤
面上项目
教授
福建医科大学
57万元
耐药;聚二磷酸腺苷核糖聚合酶;NF-κB;DNA修复;DNA损伤
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The role of the novel LincRNA uc002jit.1 in NF-kB-mediated DNA damage repair in acute myeloid leukemia cells. 期刊论文 Li D;Yu Z;Wang T;Li Y;Chen X;Wu L
2 MiR-519d-5p modulates the sensitivity of breast cancer to chemotherapy by forming a negative feedback loop with RELA. 期刊论文 Li D;Wang T;Yu Z;Zhang Y;Wu X;Zheng N;Zhang W;Wu L
3 Synthesis of Novel Dual Target Inhibitors of PARP and HSP90 and Their Antitumor Activities. 期刊论文 Lin S;Zhang L;Zhang X;Yu Z;Huang X;Xu J;Liu Y;Chen L;Wu L
4 Discovery of CN0 as a novel proteolysis-targeting chimera (PROTAC) degrader of PARP1 that can activate the cGAS/STING immunity pathway combined with daunorubicin. 期刊论文 Lin S;Tu G;Yu Z;Jiang Q;Liu J;Liu Q;Huang X;Xu J;Lin Y;Liu Y;Wu L
5 NF-κB and poly (ADP-ribose) polymerase 1 form a positive-feedback loop that regulates DNA repair in acute myeloid leukemia cells. 期刊论文 Li D;Luo Y;Chen X;Zhang L;Wang T;Zhuang Y;Fan Y;Xu J;Chen Y;Wu L
6 Positive Feedback Regulation of Poly(ADP-ribose) Polymerase 1 and the DNA-PK Catalytic Subunit Affects the Sensitivity of Nasopharyngeal Carcinoma to Etoposide. 期刊论文 Zhang L;Zhuang Y;Tu G;Li D;Fan Y;Ye S;Xu J;Zheng M;Wu Y;Wu L
7 Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer. 期刊论文 Liu Q;Tu G;Hu Y;Jiang Q;Liu J;Lin S;Yu Z;Li G;Wu X;Tang Y;Huang X;Xu J;Liu Y;Wu L
8 A PARP1 PROTAC as a novel strategy against PARP inhibitor resistance via promotion of ferroptosis in p53-positive breast cancer. 期刊论文 Li G;Lin S;Yu Z;Wu X;Liu J;Tu G;Liu Q;Tang Y;Jiang Q;Xu J;Huang Q;Wu L
9 Synthesis of novel dual target inhibitors of PARP and EGFR and their antitumor activities in triple negative breast cancers. 期刊论文 Lin S;Zhang X;Yu Z;Huang X;Xu J;Liu Y;Wu L
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