Chartelline和Chartellamide骨架化合物新合成方法研究及其抗肿瘤活性、构效关系与机制评价

81760625
2017
H3402.天然药物化学
刘雄利
地区科学基金项目
教授
贵州大学
30万元
抗肿瘤活性;chartelline;治疗靶点;Chartellamide;构效关系
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Asymmetric construction of six vicinal stereogenic centers on hexahydroxanthones via organocatalytic one-pot reactions 期刊论文 Min Zhang;Xue-Wen He;Ya Xiong;Xiong Zuo;Wei Zhou;Xiong-Li Liu
2 Design, synthesis and evaluation of structurally diverse chrysin-chromenespirooxindole hybrids as anticancer agents 期刊论文 Wen-Hui Zhang;Shuang Chen;Xiong-Li Liu;Ting-Ting Feng;Wu-De Yang;Ying Zhou
3 Efficient 1,6-addition reactions of 3-substituted oxindoles: Access to isoxazole-fused 3,30-disubstituted oxindole scaffolds and hexahydro-1h-pyrido[2,3-b]indol-2-one scaffolds 期刊论文 Xiong-Wei Liu;Zhen Yao;Guan-Lian Wang;Zhi-Yong Chen;Xiong-Li Liu;Min-Yi Tian;Qi-Di Wei;Ying Zhou;Jian-Fei Zhang
4 山酮素骨架拼接双螺环氧化吲哚化合物及其制备方法及应用 专利 刘雄利;左雄;陈爽;周根;周英;袁伟成
5 Thermal-mediated [1,3]-hydrogen transfer as the key step: access to oxindole–chromone hybrid collection with structural diversity 期刊论文 Yi Gong;Sheng-Wen Xu;Xiong-Wei Liu;Zheng Li;Xiong-Li Liu;Zhen Yao;Ying Zhou
6 An asymmetric iminium ion catalysis-enabled cascade cycloaddition reaction of chromoneoxindole synthons with enals: construction of a spirooxindole–hexahydroxanthone framework 期刊论文 Wen-Hui Zhang;Yan-you Zhou;Xue-Wen He;Yi Gong;Xiong-Li Liu;Ying Zhou
7 Dienolate-Mediated, Regioselective C2-Polarity Reversal of Chromone-Based Reactants and Their Application in Nucleophilic Strategies 期刊论文 Zhen Yao;Xiong-Wei Liu;Zheng Li;Sheng-Wen Xu;Lijin Xu;Xiong-Li Liu
8 Stereocontrolled construction of six vicinal stereogenic centers on a hexahydroxanthone framework through a formal [2+1+3] annulation 期刊论文 Shun-Qin Chang;Xiong Zou;Yi Gong;Xue-Wen He;Xiong-Li Liu;Ying Zhou
9 DNA损伤修复相关肿瘤机制与抗肿瘤化合物研究 奖励 周英;俸婷婷;刘雄利;宋旭;吴传芳;袁伟成;田维毅
10 Regioselective synthesis and evaluation of 2-amino 3-cyano chromenechrysin hybrids as potential anticancer agents 期刊论文 Hui-Juan Wang;Yan-You Zhou;Xiong-Li Liu;Wen-Hui Zhang;Shuang Chen;Xiong-Wei Liu;Ying Zhou
11 [1,5]-Proton transfer as a key strategy: Rapid access to natural product-inspired library of 3-pyrazolyl isoflavones 期刊论文 Zheng Li;Ting-Ting Feng;Ying Zhou;You-Ping Tian;Wei Zhou;Xiong-Li Liu
12 Ammonium hydroxide as the ultimate amino source for the synthesis of N-unprotected 3-tetrasubstituted aminooxindoles via catalystfree direct amination 期刊论文 Jing Yue;Xi-Tao Ma;Xiong-Li Liu;Jun-Xin Wang;Xiong-Wei Liu;Ying Zhou
13 山酮素骨架和异噁唑螺环氧化吲哚拼接衍生物及其制备方法及应用 专利 刘雄利;韦启迪;左雄;陈爽;周英;袁伟成
14 Molecular Hybridization-Guided Construction of Convolutamydine A-fused β-Ionone Scaffolds and their Biological Evaluation for Anticancer Activities 期刊论文 Xiong-Wei Liu;Jun Yang;Guan-Lian Wang;Yi Gong;Ting-Ting Feng;Xiong-Li Liu;Yu Cao;Ying Zhou;Wei-Cheng Yuan
15 色酮拼接3-羟甲基氧化吲哚衍生物及其制备方法及应用 专利 刘雄利;张文会;徐圣文;左雄;周英;田民义
16 一种色原酮吡唑啉酮骨架拼接二氢查尔酮类化合物及其制备方法及应用 专利 刘雄利;汪军鑫;周韦;常顺琴;田民义;周英
17 Regio- and stereoselective [3 + 2] cycloaddition reaction: access to isoxazole-dispirobisoxindoles featuring three contiguous stereocenters 期刊论文 Shuang Chen;Guan-Lian Wang;Sheng-Wen Xu;Min-Yi Tian;Min Zhang;Xiong-Li Liu;Wei-Cheng Yuan
18 Bifunctional oxindole-chromone 4C building block directed asymmetric synthesis of bispirocyclic hexahydroxanthones featuring five contiguous stereocenters and two side-by-side oxindoles 期刊论文 Xiong-Li Liu;Yi Gong;Shuang Chen;Xiong Zuo;Zhen Yao;Ying Zhou
19 A bifunctional pyrazolone–chromone synthon directed organocatalytic double Michael cascade reaction: forging five stereocenters in structurally diverse hexahydroxanthones 期刊论文 Xiong-Li Liu;Xiong Zuo;Jun-Xin Wang;Shun-qin Chang;Qi-Di Wei;Ying Zhou
20 Highly Efficient, Catalyst-Free, Diastereoselective, Diversity-Oriented Synthesis of Dihydrocoumarin–Pyrrolidine–Spirooxindoles Bearing Three Contiguous Stereocenters 期刊论文 Xiong Zuo;Shuang Chen;Sheng-Wen Xu;Shun-Qin Chang;Xiong-Li Liu;Ying Zhou;Wei-Cheng Yuan
21 异恶唑拼接3,3'-硫代吡咯啉酮双螺环氧化吲哚化合物及其制备方法及应用 专利 刘雄利;王关炼;常顺琴;徐胜文;汪军鑫;左雄;周英
22 环戊烷并色满酮拼接螺环氧化吲哚类化合物及其制备方法及应用 专利 刘雄利;徐圣文;周韦;周豪杰;周彦佑;何学雯;周英
23 Molecular hybridization-guided one-pot multicomponent synthesis of chromanone-fused 3,3′-pyrrolidinyldispirooxindoles through a 1,3-dipolar cycloaddition reaction 期刊论文 Yi Gong;Guan-Lian Wang;Qi-Di Wei;Lin Chen;Xiong-Li Liu;Min-Yi Tian;Jun Yang;Ting-Ting Feng;Ying Zhou
24 白杨素拼接吡喃螺环氧化吲哚类化合物及其制备方法及应用 专利 刘雄利;张文会;周英;陈爽;田民义;俸婷婷;刘雄伟
25 Organocatalytic Reaction of Chromone-Oxindole Synthon: Access to Chromanone-Based Spirocyclohexaneoxindoles with Five Adjacent Stereocenters 期刊论文 Xiong Zuo;Xiong-Li Liu;Jun-Xin Wang;Yi-Ming Yao;Yan-You Zhou;Qi-Di Wei;Yi Gong;Ying Zhou
26 Study on antitumor activities of the chrysin-chromene-spirooxindole on Lewis lung carcinoma C57BL/6 mice in vivo 期刊论文 Wen-Hui Zhang;Shuang Chen;Xiong-Li Liu;Bing-Lin;Xiong-Wei Liu;Ying Zhou
27 Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents 期刊论文 Zhi-Gang Yin;Xiong-Wei Liu;Hui-Juan Wang;Min Zhang;Xiong-Li Liu;Ying Zhou
28 Highly efficient enantioselective synthesis of bispiro[benzofuranoxindole/benzofuran-chromanone]s through organocatalytic inter-/ intramolecular Michael cycloaddition 期刊论文 Min Zhang;Jun-Xin Wang;Shun-Qin Chang;Xiong-Li Liu;Xiong Zuo;Ying Zhou
29 山酮素骨架拼接异噁唑与双螺环氧化吲哚衍生物及其制备方法及应用 专利 刘雄利;巩艺;左雄;陈爽;周英;袁伟成
30 山酮素骨架拼接氧化吲哚或苯并呋喃酮类化合物及其制备方法及应用 专利 刘雄利;汪军鑫;常顺琴;左雄;周英;袁伟成
31 Decarboxylative, Diastereoselective and exo-Selective 1,3-Dipolar Cycloaddition for Diversity-Oriented Construction of Structural Spiro[Butyrolactone–Pyrrolidine–Chromanone] Hybrids 期刊论文 Dong-Gui Guo;Zheng Li;Xiao-Xue Han;Lei Zhang;Min Zhang;Xiong-Li Liu
32 Stereocontrolled Synthesis of Bispirooxindole-Based Hexahydroxanthones with Five Contiguous Stereocenters 期刊论文 Xiong-Li Liu;Gen Zhou;Yi Gong;Zhen Yao;Xiong Zuo;Wen-Hui Zhang;Ying Zhou
33 Organocatalytic Michael/Michael Cycloaddition Enabled Asymmetric Construction of Hexahydroxanthones with Skeletal Diversity 期刊论文 Xiong-Li Liu;Qi-Di Wei;Xiong Zuo;Sheng-Wen Xu;Zhen Yao;JunXin Wang;Ying Zhou
34 Diversity-oriented regioselective domino Michael/Aldol reaction of 3-ylideneoxindoles: A direct access to indanol-fused 3-oxindoles 期刊论文 Dan-Dan Wang;Qi-Di Wei;Guan-Lian Wang;Yi Gong;Xiong-Li Liu;Gen Zhou;Ying Zhou;Jian-Fei Zhang
35 Synthesis of methanesulfone-containing tetrasubstituted carbon stereocenters 期刊论文 Wei Zhou;You-Ping Tian;Hao-Jie Zhou;Hui-Juan Wang;Yan Ren;Xiong-Li Liu
36 Thermal-mediated catalyst-free heterolytic cleavage of 3-halooxindoles: rapid access to 3-functionalized-2-oxindoles 期刊论文 Xiong-Li Liu;Jing Yue;Shuang Chen;Huan-Huan Liu;Kai-Mo Yang;Ting-Ting Feng;Ying Zhou
37 Recent advances of chromone-based reactants in the catalytic asymmetric domino annulation reaction 期刊论文 Min Zhang;Yi Gong;Wei Zhou;Ying Zhou;Xiong-Li Liu
38 Highly Diastereo-, α-Regioselective Catalyst-Free Construction of Adjacent Dispirobisoxindoles with Three Contiguous Quaternary Carbon Centers 期刊论文 Xiong-Li Liu;Shun-Qin Chang;Yan Jiang;Sheng-Wen Xu;Xiong Zuo;Shuang Chen;Min-Yi Tian
39 二氢色原酮骨架拼接多环吡咯螺环氧化吲哚化合物及其制备方法及应用 专利 刘雄利;岳静;陈爽;汪军鑫;徐圣文;周英
40 3-叔胺四取代氧化吲哚化合物及其制备方法 专利 刘雄利;徐圣文;杨楷模;刘欢欢;岳静;陈爽
41 Transition-metal-free cascade benzannulations for synthesizing 2-hydroxybenzophenones 期刊论文 Xue-Wen He;Wei Zhou;Min Zhang;Min-Yi Tian;Hui-Juan Wang;You-Ping Tian;Xiong-Li Liu
42 山酮素异恶唑骨架拼接吡唑啉酮或苯并呋喃酮类化合物及其制备方法及应用 专利 刘雄利;姚一鸣;常顺琴;左雄;周英;韦启迪
43 Chromone–indanedione reactant: a bifunctional 3C synthon for diastereoselective construction of skeleton-diversified bispiro- [chromanocyclopentane-oxindole-indanedione] 期刊论文 Wei Zhou;Zheng Li;You-Ping Tian;Xiao-Xue Han;Xiong-Li Liu
44 二氢色原酮拼接吡咯螺环氧化吲哚化合物及其制备方法及应用 专利 刘雄利;岳静;汪军鑫;徐圣文;常顺琴;周英
45 Catalytic Asymmetric Domino Michael/Annulation Reaction of Bifunctional Chromone Synthons with ,-Unsaturated -Keto Esters: Rapid Access to Polysubstituted Spirocyclic Hexahydroxanthones 期刊论文 Hao-Jie Zhou;Wei Zhou;Xiong-Li Liu;You-Ping Tian;Jun-Xin Wang;Ying Zhou
46 Oxindole-chromones C3 Synthons Directed Stereocontrolled Construction of Five Contiguous Stereocenters on Spiro [tetrahydrocyclopenta[b]chromanone-oxindole]s 期刊论文 Sheng-Wen Xu;Xiong-Wei Liu;Xiong Zuo;Gen Zhou;Yi Gong;Xiong-Li Liu;Ying Zhou
47 含连续三季碳的硫代吡咯酮拼接双螺环氧化吲哚化合物及其制备方法及应用 专利 刘雄利;常顺琴;陈爽;左雄;徐圣文;姚一鸣;周英
48 吡唑啉酮山酮素骨架拼接氧化吲哚或苯并呋喃酮类化合物及其制备方法及应用 专利 刘雄利;汪军鑫;左雄;陈爽;周英;袁伟成
49 二氢香豆素骨架拼接硫代吡咯啉酮螺环氧化吲哚化合物及其制备方法及应用 专利 刘雄利;左雄;陈爽;常顺琴;徐圣文;周英
50 Diastereoselective construction of structurally diverse trifluoromethyl bispiro-[oxindole-pyrrolidine-chromanone]s through [3þ2] cycloaddition reactions 期刊论文 Zheng Li;Yu Lu;You-Ping Tian;Xiao-Xue Han;Xiang-Wei Liu;Ying Zhou;Xiong-Li Liu
51 Molecular hybridization-guided annulation reactions of isatins with 4-methylpent-3-en-2-one: A direct access to spirooxindole tetrahydropyranones 期刊论文 Gen Zhou;Qi-Di Wei;Guan-Lian Wang;Yi Gong;Huan-Huan Liu;Xiong-Li Liu;Lin Chen;Ying Zhou
52 Diversity-oriented Construction of Chromanone-fused Polycyclic Pyrrolidinyl-dispirooxindoles 期刊论文 Ting-Ting Feng;Yi Gong;Qi-Di Wei;Guan-Lian Wang;Huan-Huan Liu;Min-Yi Tian;Xiong-Li Liu;Zhi-Yong Chen;Ying Zhou
53 DBU-Catalyzed Inter- and Intramolecular Double Michael Addition of Donor–Acceptor Chromone-Pyrazolone/Benzofuranone Synthons: Access to Spiro-Pyrazolone/Benzofuranone-Hexahydroxanthone Hybrids 期刊论文 Qi Di Wei;Yi-Ming Yao;Shun-Qin Chang;Wu-De Yang;Min-Yi Tian;Xiong-Li Liu;Ying Zhou
54 One-pot multicomponent construction of chromanone-fused pyrrolidinyl spirooxindole collections through a decarboxylative 1,3-dipolar [3þ2] cycloaddition reaction 期刊论文 Shuang Chen;Jing Yue;Xiong-Li Liu;Jun-Xin Wang;Xiong Zuo;Yu Cao
55 山酮素骨架拼接螺环氧化吲哚类化合物及其制备方法及应用 专利 刘雄利;周彦佑;何学雯;常顺琴;周英
56 Diversity-oriented TsOH catalysis-enabled construction of tanshinone-substituted bis(indolyl/pyrrolyl)methanes and their biological evaluation for anticancer activities 期刊论文 Xiong-Wei Liu;Zhi-Yong Chen;Guan-Lian Wang;Xi-Tao Ma;Yi Gong;Xiong-Li Liu;Ting-Ting Feng;Ying Zhou
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