基于miRNA-144-3p介导GABA合成/转运/释放研究百合地黄汤(仲景原方)调控前额叶皮层GABA能神经元活性发挥抗抑郁作用的机制

81903948
2019
H3301.中西医结合基础理论
马柯
青年科学基金项目
副教授
山东中医药大学
20万元
抑郁症;百合地黄汤;GABA能神经元;前额叶皮层;百合病
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种具有抗抑郁功效的百合地黄汤标准煎液制备方法及应用(METHOD FOR PREPARING ANTIDEPRESSIVE STANDARD BAIHE DIHUANG DECOCTION AND USE THEREOF) 专利 马柯;王世军;王媛;赵海军;张洪秀;马山
2 Antidepressant mechanism of classical herbal formula lily bulb and Rehmannia decoction: insights from gene expression profile of medial prefrontal cortex of mice with stress-induced depression-like behavior 期刊论文 Hongxiu Zhang;Xiansu Chi;Wenchao Pan;Shijun Wang;Zhe Zhang;Haijun Zhao;Yuan Wang;Zhichun Wu;Miaomiao Zhou;Shan Ma;Qitao Zhao;Ke Ma
3 Baihe Dihuang (Lilium Henryi Baker and Rehmannia Glutinosa) decoction attenuates somatostatin interneurons deficits in prefrontal cortex of depression via miRNA-144-3p mediated GABA synthesis and release. 期刊论文 Xiaoyan Xue;Jin Pan;Hongxiu Zhang;Yanting Lu;Qiancheng Mao;Ke Ma
4 百合地黄汤治疗阴虚内热型抑郁症的机制 期刊论文 潘瑾;潘文超;迟显苏;薛晓燕;高志礼;王墉;马铭涵;逯艳婷;马婷;马柯
5 Mechanism of lily bulb and Rehmannia decoction in the treatment of lipopolysaccharide-induced depression-like rats based on metabolomics study and network pharmacology 期刊论文 Xiansu Chi;Xiaoyan Xue;Jin Pan;Jiang Wu;Huishan Shi;Yong Wang;Yanting Lu;Zhe Zhang;Ke Ma
6 Integrated analysis of the chemical-material basis and molecular mechanisms for the classic herbal formula of Lily Bulb and Rehmannia Decoction in alleviating depression 期刊论文 Hongxiu Zhang;Xiaoyan Xue;Jin Pan;Xiaobin Song;Xing Chang;Qiancheng Mao;Yanting Lu;Haijun Zhao;Yuan Wang;Xiansu Chi;Shijun Wang;Ke Ma
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