苯乙烯环氧化酶和羰基还原酶偶联体系的构建及其在手性烯丙型环氧仲醇和环氧酮合成中的应用

21572220
2015
B0111.仿生与绿色合成
吴中柳
面上项目
研究员
中国科学院成都生物研究所
65万元
烯丙型环氧醇;不对称环氧化;b-不饱和酮;a;苯乙烯环氧化酶;羰基还原酶
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Efficient bioreductive production of (S)-N-Boc-3-hydroxypiperidine using ketoreductase ChKRED03 期刊论文 Xu Guang-Peng;Wang Hai-Bo;Wu Zhong-Liu
2 Asymmetric bio-epoxidation catalyzed with the styrene monooxygenase from Pseudomonas sp. LQ26 期刊论文 Yan Liu;Yuchang Liu;Zhongliu Wu
3 Two "classical"Old Yellow Enzymes from Chryseobacterium sp. CA49: Broad substrate specificity of Chr-OYE1 and limited activity of Chr-OYE2 期刊论文 Pei Xiao-Qiong;Xu Meng-Yu;Wu Zhong-Liu
4 一种可调控多酶级联反应用于合成光学纯烯丙型环氧酮或醇 专利 吴中柳;刘育昌
5 一种新型苯乙烯环氧化酶及其功能 专利 吴中柳;蒲伟
6 Bioreductive dynamic kinetic resolution of ethyl 2-methoxy-3-oxo-3-phenylpropanoate. 期刊论文 Chao Li;XIaoqiong Pei;Dong Yi;Tongbiao Li;Zhongliu Wu
7 Switchable asymmetric bio-epoxidation of alpha,beta-unsaturated ketones 期刊论文 Liu Yu-Chang;Wu Zhong-Liu
8 Enzymatic cascades for the stereo-complementary epimerisation of in situ generated epoxy alcohols 期刊论文 Liu Yu Chang;Guo Chao;Liu Yan;Wang Hai Bo;Wu Zhong Liu
9 Rapid asymmetric reduction of ethyl 4-chloro-3-oxobutanoate using a thermostabilized mutant of ketoreductase ChKRED20 期刊论文 Zhao Feng-Jiao;Pei Xiao-Qiong;Ren Zhi-Qiang;Wu Zhong-Liu
10 Functional characterization of an (R)-selective styrene monooxygenase from streptomyces sp. NRRL S-31 期刊论文 Can Cui;Chao Guo;Hui Lin;ZhaoYun Ding;Yan Liu;Zhongliu Wu
11 Stereo-complementary bioreduction of saturated N-heterocyclic ketones 期刊论文 Li Chao;Liu Yan;Pei Xiao Qiong;Wu Zhong Liu
12 Structure-guided engineering of ChKRED20 from Chryseobacterium sp. CA49 for asymmetric reduction of aryl ketoesters 期刊论文 Li Tong Biao;Zhao Feng Jiao;Liu Zhongchuan;Jin Yun;Liu Yan;Pei Xiao Qiong;Zhang Zhi Gang;Wang Ganggang;Wu Zhong Liu
13 一种来自链霉菌的(R)-选择性苯乙烯单加氧酶 专利 吴中柳;崔璨;郭超;丁照云;刘艳
14 Characterization of two styrene monooxygenases from marine microbes 期刊论文 Pu Wei;Cui Can;Guo Chao;Wu Zhong Liu
15 Improving the thermostability of feruloyl esterase by DNA shuffling and site-directed mutagenesis 期刊论文 Jing-Jing Li;Xiao-Qiong Pei;Shuai-Bing Zhang;Zhong-Liu Wu
16 Construction and functional analysis of a whole-cell biocatalyst based on CYP108N7 期刊论文 Guo Chao;Wu Zhong-Liu
17 Biocatalytic Epoxidation for Green Synthesis 专著 Hui Lin;Meng-Yu Xu;Yan Liu;Zhong-Liu Wu
18 Crystal structure and iterative saturation mutagenesis of ChKRED20 for expanded catalytic scope 期刊论文 Zhao Feng-Jiao;Jin Yun;Liu Zhongchuan;Guo Chao;Li Tong-Biao;Li Zi-Yi;Wang Ganggang;Wu Zhong-Liu
19 Stereoselective bioreduction of ethyl 3-oxo-3-(2-thienyl) propanoateusing theshort-chain dehydrogenase/reductase ChKRED12 期刊论文 Zhiqiang Ren;Yan Liu;Xiaoqiong Pei;Zhongliu Wu
20 Single mutations of ketoreductase ChKRED20 enhance the bioreductive production of (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol 期刊论文 Zhao Feng-Jiao;Liu Yan;Pei Xiao-Qiong;Guo Chao;Wu Zhong-Liu
21 羰基还原酶ChKRED20突变体及其用途 专利 吴中柳;赵凤佼;刘艳;裴小琼;郭超
22 Two "classical"Old Yellow Enzymes from Chryseobacterium sp. CA49: Broad substrate specificity of Chr-OYE1 and limited activity of Chr-OYE2 期刊论文 Pei Xiao-Qiong;Xu Meng-Yu;Wu Zhong-Liu
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