基于多胺转运的萘酰亚胺类小分子化合物对肿瘤细胞凋亡信号通路的影响
90913001
2009
B0706.药物化学生物学
王超杰
重大研究计划
教授
河南大学
50万元
萘酰亚胺;细胞凋亡;靶向修饰;PI3K/AKT/mTOR
2010-01-01到2012-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway | 期刊论文 | Xie, Song-qiang|Zhang, Ya-hong|Li, Qian|Xu, Feng-hua|Miao, Jiu-wang|Zhao, Jin|Wang, Chao-jie| |
| 2 | Reactive oxygen species (ROS) accumulation induced by mononaphthalimide-spermidine leads to intrinsic and AIF-mediated apoptosis in HeLa cells | 期刊论文 | Yang, Lianhe|Zhao, Jin|Zhu, Yanqin|Tian, Zhiyong|Wang, Chaojie| |
| 3 | 乙酰水杨酸增强多胺衍生物ANISpm抗肝癌作用及其机制研究 | 期刊论文 | 谢松强|XIE Song-qiang 1,2,ZHANG Lei-lei 3,YANG Tao 1,2,MA|2.The Key Laboratory of Natural Medicine and Immun|3.Department of Pathology,Affiliated Huaihe Hospit|张蕾蕾|杨涛|马莹|张亚宏|李骞|王建红|赵瑾|王超杰| |
| 4 | 多胺衍生物NNIspm诱导肝癌细胞HepG2衰老及其分子机制 | 期刊论文 | 谢松强|2.The Key Laboratory of Natural Medicine and Immun|张亚宏|卢慧芳|申阿春|李骞|李景华|赵瑾|王超杰|XIE Song-qiang1,2,ZHANG Ya-hong2,LU Hui-fang1,2,SH| |
| 5 | COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines | 期刊论文 | Xie, Song-qiang|Zhang, Ya-hong|Li, Qian|Wang, Jian-hong|Li, Jing-hua|Zhao, Jin|Wang, Chao-jie| |
| 6 | NPC-16, a novel naphthalimide-polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells | 期刊论文 | Xie, Song-qiang|Li, Qian|Zhang, Ya-hong|Wang, Jian-hong|Mei, Zi-hou|Zhao, Jin|Wang, Chao-jie| |
| 7 | Nonhematotoxic Naphthalene Diimide Modified by Polyamine: Synthesis and Biological Evaluation | 期刊论文 | Wang, Yuxia|Zhang, Xingbo|Zhao, Jin|Xie, Songqiang|Wang, Chaojie| |
| 8 | Mononaphthalimide spermidine conjugate induces cell proliferation inhibition and apoptosis in HeLa cells | 期刊论文 | Yang, Lianhe|Li, Wei|Tian, Zhiyong|Zhao, Jin|Wang, Chaojie| |
| 9 | Antitumor conjugates with polyamine vectors and their molecular mechanisms. | 期刊论文 | 王超杰| |
| 10 | 萘酰亚胺-多胺缀合物NNINspm通过PI3 K/Akt信号通路诱导肝癌细胞凋亡 | 期刊论文 | 谢松强|李骞|张亚宏|王建红|赵瑾|王超杰|XIE Song-qiang1,2,LI Qian2,ZHANG Ya-hong2,WANG Jia|2.The Key Laboratory of Natural Medicine and Immun| |
| 11 | BND-12, a novel nonhaematotoxic naphthalimide derivative, inhibits tumour growth and metastasis of hepatocellular carcinoma | 期刊论文 | Xie, Song-qiang|Li, Qian|Zhang, Ya-hong|Li, Zhan|Zhao, Jin|Wang, Chao-jie| |
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