新型氟代HMG-CoA还原酶抑制剂的设计与合成

21172148
2011
B0101.元素化学
吴范宏
面上项目
教授
上海应用技术大学
60万元
合成;含氟结构修饰;设计;HMG-CoA还原酶抑制剂
2012-01-01到2015-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Crystalstructure and mechanistic investigation of the reaction of5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)--1H-pyrazole-3-carbonitrilewith unsaturated carbonyl compounds 期刊论文 Chuanxiang Liu|Yong Chen|Yingxin Sun|fanhong wu|
2 Synthesis andin vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones 期刊论文 Shaowu Zhang|Zhi Wang|Hui Wang|Fanhong Wu|
3 Pd-Catalyzed C-H Activation/C=C Bond Formation: A New Route to 3-Fluoromethyl Substituted Pyrazol-4-acrylates 会议论文 Chao Fang|Xiang Fang|Hongyuan Xiao|Fanhong Wu|
4 Molecular modeling studies of atorvastatin analogues as HMGR inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations 期刊论文 Wang Z.|Cheng L. P.|Kai Z. P.|Wu F. H.|
5 Derivatives of α,α-aryl Naphthalimide Nitriles as Fluoride ion Sensors: Convenient Precursors for the Synthesis of Aryl Naphthalimide Ketones 期刊论文 Chen J. J.|Liu C. X.|Guan F.|Wu F. H.|
6 Highly enantioselective construction of 3-hydroxy oxindoles through a decarboxylative aldol addition of trifluoromethyl α-fluorinated gem-diols to n-benzyl isatins 期刊论文 He, Xiao-Peng|Liang, Jing|Yang, Xueyan|Wu, Fanhong|
7 A metal-free and recyclablesynthesis of benzothiazoles using thiourea as a sulfur surrogate 期刊论文 Heng Zhang|Ruiheng Tao|Fengkai Cheng|Yangbo Feng|
8 Synthesis of 1,3,5-Trisubstituted [4-tert-Butyl 2-(5,5-difluoro- 2,2-dimethyl-6-vinyl-1,3-dioxan-4-yl)acetate]pyrazoles via a Pd-Catalyzed C—H Activation 期刊论文 Fang, Xiang|Yang, Xueyan|Ni, Meng|Wu, Fanhong|
9 A Green and Novel Method for the Synthesis of 4,4-Difluoro-3-oxo-2-(triphenylphosphoranylidene) delta-Lactones by Reformatsky Reaction 期刊论文 Fang Xiang|Zhang Dong|Liu Wu|Wu Fanhong|
10 Microwave-assisted fast synthesis of 5-fluorine-containing-3-aryl-1, 3--oxazolidin-2-ones 会议论文 Xueyany Yang|Xiang Fang|Zhonghua Wang|Fanhong Wu|
11 Synthesis of g,g-difluoro-b-hydroxy-d-lactones as new precursors of HMG-CoA reductase inhibitor 期刊论文 Hongyuan Xiao|Yan Yin|Huimin Xia|Fanhong Wu|
12 3D-QSAR and Docking Studies on 2-acyliminobenzimidazoles Derivatives as Potent ALK Inhibitors 期刊论文 Lv Q. Q.|Wang Z.|Wang Z. H.|Wu F. H.|
13 Synthesis of Fluoroalkylated Allylic-β-hydroxyesters and Fluoroalkylated β,γ-Epoxy Esters from Ethyl 3-Hydroxy-4-pentenoate 期刊论文 Xiong, Ying|Wang, Qiong|Zhao, Min|Wu, Fanhong|
14 Synthesis of Fluoroalkylated Allylic-beta-hydroxyesters and Fluoroalkylated beta,Y-Epoxy Esters from Ethyl 3-Hydroxy-4-pentenoate 期刊论文 Xiong Ying|Wang Qiong|Zhao Min|Wu Fanhong|
15 A Green and Novel Method for the Synthesis of 4,4-Difluoro-3- oxo-2-(triphenylphosphoranylidene) δ-Lactones by Reformatsky Reaction 期刊论文 Fang, Xiang|Zhang, Dong|Liu, Lu|Wu, Fanhong|
16 One-Pot Addition–Intramolecular N-Cyclization of Carbamates Mediated by Alkali Metallic Reagents as an Approach to 4-(Fluoroalkyl)oxazolidin-2-ones 期刊论文 Fang, Xiang|Ju, Zhenghua|Hu, Yunli|Wu, Fanhong|
17 Organocatalytic Enantioselective Michael Addition/Carbon-Carbon Bond Cleavage of Trifluoromethyl α-Fluoro-β-dicarbonyls to β-Nitroole？nes Promoted by Chiral Thiourea Catalyst 会议论文 Ibrayim Saidalimu|Xiang Fang|Yanlin Yu|Fanhong Wu|
18 Discovery of potent and selective urea-based ROCKinhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by3D-QSAR, molecular docking and molecular dynamics simulations 期刊论文 Hong Zhou|Guofeng Sun|Yu Jiang|Yangbo Feng|
19 One-Pot Addition-Intramolecular N-Cyclization of Carbamates Mediated by Alkali Metallic Reagents as an Approach to 4-(Fluoroalkyl)oxazolidin-2-ones 期刊论文 Fang, Xiang|Ju, Zheng-Hua|Hu, Yun-Li|Wu, Fan-Hong|
20 Efficient synthesis of 5-fluoroalkyloxazoles via fluoroalkylation of N-allyl ureas 会议论文 Xiang Fang|Yunli Hu|Jing Liang|Fanhong Wu|
21 Regioselective nucleophilic addition of 3-aryl-5-difluoromethyl-isoxazoles to aldehydes. 期刊论文 Dong Zhang|Yanlin Yu|Zhengdong Zhang|Fanhong Wu|
22 Derivativesof α,α-aryl Naphthalimide Nitriles as Fluoride ion Sensors, Convenient Precursors for the Synthesis ofAryl Naphthalimide 期刊论文 Kai Ji|Xinyu Wang|Min Xu|fanhong wu|
23  Enantioselective Reformatsky Reaction between Cinnamaldehyde and Diflurinated Organozinc Reagent: Synthesis of Chiral γ,γ-difluoro-β-hydroxy Esters as Precursors of Statin Analogs. 期刊论文 Fang C.|Yin Y.|Zhang H.|Wu F. H.|
24 The research for introducing gem-difluoromethylene group into the organic molecules. 期刊论文 Fang C.|吴范宏|
25 HighlyRegio- and Diastereoselective Addition of Organolithium Reagents to ChiralFluoroalkyl α,β-Unsaturated N-tert- Butanesulfinyl Ketimines, A General and Efficient Access to TertiaryFluoroalkyl Allylic Amines and α-Fluoroalkyl α-Amino Acids. 期刊论文 Peng Liu|Zhenjiang Liu|fanhong wu|
26 Highly Regio- and Diastereoselective Addition of Organolithium Reagents to Chiral Fluoroalkyl α,β-Unsaturated N-tert- Butanesulfinyl Ketimines: A General and Efficient Access to Tertiary Fluoroalkyl Allylic Amines and α-Fluoroalkyl α-Amino Acids 期刊论文 Liu P.|Liu Z. J.|Wu F. H.|
27 Organocatalytic Asymmetric Michael Addition/Carbon-Carbon Bond Cleavage of Trifluoromethyl alpha-Fluorinated gem-Diols to Nitroolefins 期刊论文 Yang, Xueyan|He, Xiaopeng|Zhang, Jingyuan|Wu, Fanhong|
28 Synthesis of gamma,gamma-difluoro-beta-hydroxy-delta-lactones as new precursors of HMG-CoA reductase inhibitor 期刊论文 Xiao, Hongyuan|Yin, Yan|Xia, Huimin|Wu, Fanhong|
29 Synthesis of 1,3,5-Trisubstituted [4-tert-Butyl 2-(5,5-difluoro-2,2-dimethyl-6-vinyl-1,3-dioxan-4-yl) acetate]pyrazoles via a Pd-Catalyzed C—H Activation 期刊论文 Xiang Fang|Xueyan Yang|Meng Li|Fanhong Wu|
30 A Convenient Synthesis of 3-Aryl-4-fluoroalkyl-2-oxazolidinone 期刊论文 Zhao Min|Fang Xiang|Yang Xueyan|Wu Fanhong|
31 Microwave-assisted expeditious synthesis of 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2-ones 期刊论文 Wu, JingJing|Fang, Xiang|Yang, Xueyan|Wu, Fanhong|
32 cRGDyK-modified camretastain A4-loaded grapheneoxide nanosheets for targeted anticancer drug delivery 期刊论文 Qingqing Tian|Fang Ding|Yanyan Yu|Fanhong Wu|
33 一种有效合成3-芳基-4-氟烷基-2-噁唑烷酮的方法 期刊论文 赵敏|方向|杨雪艳|吴范宏|
34 一种有效合成5-氟烷基噁唑啉的方法 期刊论文 杨波|方向|杨雪艳|吴范宏|
35 Synthesis of difluoroalkyl-γ-butyrolactones fromiododifluoromethyl ketones and 4-pentenoic acids 期刊论文 Jingjing Wu|Heng Chen|Shaowu Zhang|Fanhong Wu|
36 A novel chemodosimeter for fluoride ions based on deprotonation of the C–H group followed by an autoxidative decyanation process 期刊论文 Jiali Zhang|Wen Ding|Min Zhou|Fanhong Wu|
37 HighlyRegio- and Diastereoselective Addition of Organolithium Reagents to ChiralFluoroalkyl α,β-Unsaturated N-tert- Butanesulfinyl Ketimines, A General and Efficient Access to TertiaryFluoroalkyl Allylic Amines and α-Fluoroalkyl α-Amino Acids. 期刊论文 Peng Liu|Zhenjiang Liu|fanhong wu|
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