基于稳定同位素标记衍生化的靶向脂质组学LC-MS分析方法

21775088
2017
B0403.谱学方法与理论
赵先恩
面上项目
教授
曲阜师范大学
64万元
分析方法学开发;同位素标记;液-质联用;衍生化;靶向脂质组学
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 食品中目标物的高效富集分离与低背景检测研究 奖励 夏莲;渠凤丽;李国梁;赵先恩;张世娟
2 Stable isotope labeling derivatization and magnetic dispersive solid phase extraction coupled with UHPLC-MS/MS for the measurement of brain neurotransmitters in post-stroke depression rats administrated with gastrodin 期刊论文 Zhao Xian En;He Yongrui;Zhu Shuyun;Xu Yanqiu;You Jinmao;Bai Yu;Liu Huwei
3 12-Plex UHPLC-MS/MS analysis of sarcosine in human urine using integrated principle of multiplex tags chemical isotope labeling and selective imprint enriching 期刊论文 Chen Shi-En;Hu Jingwen;Yan Ping;Sun Jing;Jia Wenhui;Zhu Shuyun;Zhao Xian-En;Liu Huwei
4 Aggregation-enhanced emission of metal nanoclusters triggered by peptide self-assembly and application in chymotrypsin inhibitor screening 期刊论文 Zi Yuqiu;Xu Dawei;Li Cong;Qu Fei;Zhao Xian-En
5 一种含羟基的胆固醇及其代谢物的检测分析方法 专利 朱树芸;汪鑫;赵先恩;徐燕秋;孙鲁平;尤进茂
6 8-Plex stable isotope labeling absolute quantitation strategy combined with dual-targeted recognizing function material for simultaneous separation and determination of glucosylsphingosine and galactosylsphingosine in human plasma 期刊论文 Chen Shi-En;Zhu Shuyun;Hu Jingwen;Sun Jing;Zheng Zhenjia;Zhao Xian-En;Liu Huwei
7 同位素标记结合超高效液相色谱-串联质谱分析神经类固醇 会议论文 徐燕秋;汪鑫;赵先恩;白玉;刘虎威
8 Cu2+ modulated DNA-templated silver nanoclusters as a turn-on fluorescence probe for the detection of quinolones 期刊论文 Wang R.;Yan X.;Sun J.;Wang X.;Zhao X.-E.;Liu W.;Zhu S.
9 稳定同位素标记衍生试剂开发及LC-MS/MS药物分析方法 会议论文 赵先恩;汪鑫;徐燕秋;朱树芸;白玉;刘虎威
10 同位素标记-磁固相萃取UHPLC-MS/MS分析含羟基的胆固醇代谢物与药物分子 会议论文 赵先恩;汪鑫;徐燕秋;朱树芸;尤进茂;白玉;刘虎威
11 Lead halide perovskites with aggregation-induced emission feature coupled with gold nanoparticles for fluorescence detection of heparin 期刊论文 Qu Fei;Yin Tian;Fa Qianqian;Jiang Dafeng;Zhao Xian-en
12 9-Plex ultra high performance liquid chromatography tandem mass spectrometry determination of free hydroxyl polycyclic aromatic hydrocarbons in human plasma and urine 期刊论文 Sun Luping;Zhu Shuyun;Zheng Zhenjia;Sun Jing;Zhao Xian-En;Liu Huwei
13 Recent progresses of derivatization approaches in the targeted lipidomics analysis by mass spectrometry 期刊论文 Zhao Xian-En;Zhu Shuyun;Liu Huwei
14 一种检测神经鞘氨醇己三糖苷的多通道质谱衍生试剂及其制备方法与应用 专利 赵先恩;胡静雯;朱树芸
15 Synchronous measuring of triptolide changes in rat brain and blood and its application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats 期刊论文 Zhu Shuyun;Wang Xin;Zheng Zhenjia;Zhao Xian-En;Bai Yu;Liu Huwei
16 A convenient fluorescent assay for quinolones based on their inhibition towards the oxidase-like activity of Cu2+ 期刊论文 Zhu Shuyun;Cao Han;Yan Xiaolu;Sun Jing;Qiu Jiayi;Qu Xiaoqing;Zuo Ya-Nan;Wang Xiao;Zhao Xian-En
17 Colorimetric determination of the activities of tyrosinase and catalase via substrate-triggered decomposition of MnO2 nanosheets 期刊论文 Zhao Xian-En;Zuo Ya-Nan;Qu Xiaoqing;Sun Jing;Liu Lingyuan;Zhu Shuyun
18 衍生化-磁固相萃取高效液相色谱荧光检测内分泌干扰物 期刊论文 孙怡琳;亢洋;郑龙芳;张琬茹;马爱新;赵建;王晓;赵先恩
19 检测神经鞘氨醇葡萄糖苷和神经鞘氨醇半乳糖苷的多通道质谱衍生试剂及其制备方法与应用 专利 赵先恩;陈世恩;朱树芸
20 Probing NAD( )/NADH-dependent biocatalytic transformations based on oxidase mimics of MnO2 期刊论文 Zhu Shuyun;Lei Cuihua;Sun Jing;Zhao Xian En;Wang Xiao;Yan Xiaolu;Liu Wei;Wang Hua
21 A "turn-on" fluorescence sensor for ascorbic acid based on graphene quantum dots: Via fluorescence resonance energy transfer 期刊论文 Gao Y.;Yan X.;Li M.;Gao H.;Sun J.;Zhu S.;Han S.;Jia L.-N.;Zhao X.-E.;Wang H.
22 Molecular beacon-templated silver nanoclusters as a fluorescent probe for determination of bleomycin via DNA scission. 期刊论文 Yan Xiaolu;Sun Jing;Zhao Xian-En;Wang Renjun;Wang Xiao;Zuo Ya-Nan;Liu Wei;Kong Rongmei;Zhu Shuyun
23 Simple and label-free fluorescence detection of ascorbic acid in rat brain microdialysates in the presence of catecholamines 期刊论文 Zhu S.;Lei C.;Gao Y.;Sun J.;Peng H.;Gao H.;Zhang R.;Wang R.;Zhao X.-E.;Wang H.
24 多通道衍生试剂设计合成与LC-MS/MS分析方法 会议论文 朱树芸;孙鲁平;陈世恩;胡静雯;贾文惠;赵先恩;白玉;刘虎威
25 一种含羟基的神经类固醇的检测分析方法 专利 朱树芸;徐燕秋;赵先恩;汪鑫;白玉;刘虎威
26 Multiplexed derivatization strategy-based dummy molecularly imprinted polymers as sorbents for magnetic dispersive solid phase extraction of globotriaosylsphingosine prior to UHPLC-MS/MS quantitation 期刊论文 Hu Jingwen;Zhu Shuyun;Chen Shi-En;Liu Ruisheng;Sun Jing;Zhao Xian-En;Liu Huwei
27 Graphene quantum dots combined with the oxidase-mimicking activity of Ce 4+for ratiometric fluorescent detection of Ce 4+and alendronate sodium 期刊论文 Xia Meng;Zhao Xian-En;Sun Jing;Zheng Zhenjia;Zhu Shuyun
28 Convenient and sensitive colorimetric determination of alendronate sodium with Ce4+-triggered oxidation of TMB 期刊论文 Sun Jing;Wang Rui;Xia Meng;Zhu Shuyun;Zhao Xian-En
29 Derivatization-based magnetic dummy molecularly imprinted polymers integrated with 4-plex stable isotope labeling derivatization strategy for specific and rapid determination of L-hydroxyproline in human serum 期刊论文 Zhu Shuyun;Zheng Longfang;Sun Luping;Jia Wenhui;Sun Jing;Zhao Xian-En;Liu Huwei
30 A fluorescence strategy for monitoring alpha-glucosidase activity and screening its inhibitors from Chinese herbal medicines based on Cu nanoclusters with aggregation-induced emission 期刊论文 Li Cong;Zi Yuqiu;Xu Dawei;Jiang Dafeng;Qu Fei;Zhao Xian-En
31 pH-modulated aggregation-induced emission of Au/Cu nanoclusters and its application to the determination of urea and dissolved ammonia 期刊论文 Qu Fei;Chen Yanan;Jiang Dafeng;Zhao Xian-en
32 Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats. 期刊论文 Zheng Zhenjia;Zhao Xian-En;Zhu Shuyun;Dang Jun;Qiao Xuguang;Qiu Zhichang;Tao Yanduo
33 Aggregation-induced emission of lead halide perovskites modulated by dispersed/aggregated gold nanoparticles for application in the detection of dopamine 期刊论文 Qu Fei;Fa QianQian;Yin Tian;Jiang Dafeng;Zhao Xian-en
34 基于化学衍生化的靶向脂质组学质谱分析研究进展 期刊论文 赵先恩;白玉;刘虎威
35 功能化纳米材料增强的医学传感技术及食品污染物的分析检测技术研究 奖励 朱树芸;李国梁;渠凤丽;夏莲;赵先恩;尤进茂
36 一种检测羟基多环芳烃的多通道质谱衍生试剂及其制备方法与应用 专利 朱树芸;孙鲁平;赵先恩
37 Integration of stable isotope labeling derivatization and magnetic dispersive solid phase extraction for measurement of neurosteroids by in vivo microdialysis and UHPLC-MS/MS 期刊论文 Xu Yanqiu;Sun Luping;Wang Xin;Zhu Shuyun;You Jinmao;Zhao Xian En;Bai Yu;Liu Huwei
38 Quadruplex stable isotope derivatization strategy for the determination of panaxadiol and panaxatriol in foodstuffs and medicinal materials using ultra high performance liquid chromatography tandem mass spectrometry 期刊论文 Zhu Shuyun;Zheng Zhenjia;Peng Hongwei;Sun Jing;Zhao Xian-En;Liu Huwei
39 一种生物样本中微量雷公藤甲素的检测分析方法 专利 朱树芸;汪鑫;赵先恩;徐燕秋;白玉;刘虎威
40 Stable isotope labeling derivatization coupled with magnetic dispersive solid phase extraction for the determination of hydroxyl-containing cholesterol and metabolites by in vivo microdialysis and ultra-high performance liquid chromatography tandem mass spectrometry 期刊论文 Wang Xin;Sun Jing;Zhao Xian En;Xu Yanqiu;Sun Luping;Zhu Shuyun;You Jinmao;Wang Xiao
41 Probing glutathione reductase activity with graphene quantum dots and gold nanoparticles system 期刊论文 Yan X.;Zhao X.-E.;Sun J.;Zhu S.;Lei C.;Li R.;Gong P.;Ling B.;Wang R.;Wang H.
42 基于多标衍生试剂的靶向脂质组学LC-MS分析 会议论文 陈世恩;胡静雯;孙鲁平;刘瑞生;赵先恩;白玉;刘虎威
43 Ratiometric fluorescence detection of bleomycin based on proximity-dependent fluorescence conversion of DNA-templated silver nanoclusters 期刊论文 Liu Lingyuan;Zhu Shuyun;Sun Jing;Xia Meng;Zhao Xian'en;Xu Guobao
44 荧光衍生化- 磁分散固相萃取/高效液相色谱检测池塘水与蔬菜中3种挥发性异味物质 期刊论文 陈坤;张鹏;王妍;郑振佳;董京磊;孙鲁平;朱树芸;赵先恩
45 13-Plex UHPLC-MS/MS Analysis of Hexanal and Heptanal Using Multiplex Tags Chemical Isotope Labeling Technology 期刊论文 Hu Jingwen;Chen Shi-En;Zhu Shuyun;Jia Wenhui;Sun Jing;Zhao Xian-En;Liu Huwei
46 Core-shell magnetic molecularly imprinted polymers used rhodamine B hydroxyproline derivate as template combined with in situ derivatization for the specific measurement of L-hydroxyproline. 期刊论文 Zheng Longfang;Zhao Xian-En;Ji Wenhua;Wang Xiao;Tao Yanduo;Sun Jing;Xu Yanqiu;Wang Xin;Zhu Shuyun;You Jinmao
47 MOF@MnO2 nanocomposites prepared using in situ method and recyclable cholesterol oxidase-inorganic hybrid nanoflowers for cholesterol determination 期刊论文 Xu Dawei;Li Cong;Zi Yuqiu;Jiang Dafeng;Qu Fei;Zhao Xian-En
48 In situ growth of polydopamine on surface of covalent organic frameworks under the catalysis of acid phosphatase for dopamine detection 期刊论文 Qu Fei;Guo Ziwei;Jiang Dafeng;Zhao Xian-En
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