【21162001】新型抗血吸虫药物的合成与筛选研究国家自然基金项目

新型抗血吸虫药物的合成与筛选研究

项目批准号： 21162001

批准年份： 2011

学科分类： B0706.药物化学生物学

项目负责人：刘良先

资助类别：地区科学基金项目

负责人职称：教授

依托单位：赣南师范大学

资助金额： 50万元

关键词：抗血吸虫药物;交叉偶联反应;噁二唑-2-氧;吡喹酮

起止时间： 2012-01-01到2015-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	A Highly Efficient Synthesis of 2,5-Disubstituted Furans from Enyne Acetates Catalyzed by Lewis Acid and Palladium	期刊论文	Yue-Lu Wen\|Min Ye\|Zhong-Gao Zhou\|Liang-Xian Liu\|
2	Metal-free (Boc)2O-mediated C4-selective direct indolation of pyridines using TEMPO	期刊论文	Yu-Bo Kong\|Yun-Hong Bao\|Zheng-Wang Chen\|Liang-Xian Liu\|
3	Highly efficient synthesis of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates	期刊论文	Dongnai Ye\|Guohai Xu\|Min Ye\|Liangxian Liu\|
4	Copper-catalyzed oxidative trimerization of indoles by using TEMPO to construct quaternary carbon centers: the synthesis of 2-(1H-indol-3-yl)-2,3'-biindolin-3-ones	期刊论文	Yu-Bo Kong\|Jia-Yi Zhu\|Zheng-Wang Chen\|Liang-Xian Liu\|
5	One-Pot Synthesis of Bis(indolyl)methanes: Ruthenium-CatalyzedReaction of Benzylic Alcoholes and Indoles	期刊论文	Ning Wang\|Lei Shu\|Qiaosheng Hu\|Liangxian Liu\|
6	Silver-catalyzed TEMPO oxidative homocoupling of indoles for the synthesis of 3,3'-biindolin-2-ones	期刊论文	Yu Chen\|Baoshuang Wang\|Wenbing Qin\|Liangxian Liu\|
7	Synthesis and pharmacological evaluation of novel bisindole derivatives bearing oximes moiety: identification of novel proapoptotic agents	期刊论文	J.-L. Li\|M.-Y. Ye\|H.-S. Wang\|L.-X. Liu\|
8	Metal-free catalyzed oxidative trimerization of indoles by using TEMPO in air: a biomimetic approach to 2-(1H-indol-3- yl)-2,3'-biindolin-3-ones	期刊论文	刘良先\|
9	Metal-free catalyzed oxidative trimerization of indoles by using TEMPO in air: an entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones	期刊论文	Hai-Qinq Luo\|Yun-Hong Bao\|Zheng-Wang Chen\|Liang-Xian Liu\|
10	AgF/TFA-promoted highly efficient synthesis of α-haloketones from haloalkynes	期刊论文	MinYe\|Zhong-Gao Zhou\|Shen-Huan Li\|Liang-Xian Liu\|
11	Transition-metal-free semihydrogenation of diarylalkynes: highly stereoselective synthesis of trans-alkenes using Na2S·9H2O	期刊论文	Miaoting Luo\|Yuelu Wen\|Guotian Luo\|Liangxian Liu\|
12	RuCl3-DCHA catalyst system: a selective aerobic oxidation of primary benzylic alcohols under mild conditions	期刊论文	刘良先\|
13	Three-component, four-molecule, Ru-catalyzed cascade reactions of indoles and alkyl bromides with sodium nitrite	期刊论文	Jiuling Li\|Huiliang Li\|Hengshan Wang\|Liangxian Liu\|
14	Palladium-catalyzed Oxidation of Benzyl Ketones to Synthesis of Acetoxy Ketones Using Molecular Oxyge	期刊论文	Zheng-Wang Chen\|Dong-Nai Ye\|Min Ye\|Liang-Xian Liu\|
15	Iron (Ш) trichloride-catalyzed one-pot three-component coupling of indoles and sodium nitrite: a convenient synthesis of 2,3'-bi(3H-indol)-3-one oximes	期刊论文	Wenbing Qin\|Qiong Chang\|Qiaosheng Hu\|Liangxian Liu\|
16	Cu(II)-catalyzed highly regio– and stereoselective construction of C-C double bonds: an efficient method for the ketonization-olefination of indoles	期刊论文	Yu-Bo Kong\|Zheng-Wang Chen\|Shao-Bin Tang\|Liang-Xian Liu\|
17	Metal-free catalyzed oxidative trimerization of indoles by using NaNO2 to construct quaternary carbon centers: the synthesis of 2-(1H-indol-3-yl)-2,3'-biindolin-3-ones	期刊论文	Yubo Kong\|Hongen Qu\|Zheng-Wang Chen\|Liang-Xian Liu\|
18	Metal-free catalyzed oxidative trimerization ofindoles by using TEMPO in air: a biomimetic approach to 2-(1H-indol-3-yl)-2,3'-biindolin-3-ones	期刊论文	Yun-Hong Bao\|Ning Wang\|Zheng-Wang Chen\|Liang-Xian Liu\|
19	Highly efficient AgBF4-catalyzed synthesis of methylketones from terminal alkynes	期刊论文	Dong-Nai Ye\|Yi-Ping Qian\|Min Ye\|Liang-Xian Liu\|
20	Methylsulfonic acid adsorbed on silica gel as a solid acid for dimerization of indoles: a convenient synthesis of 2,3'-bi(3H-indol)-3-one oximes	期刊论文	Qiong Chang\|Hongen Qu\|Wenbing Qin\|Liangxian Liu\|
21	Cu(II)-Catalyzed Synthesis of Naphthalene-1,3-diamine Derivatives from Haloalkynes and Amines	期刊论文	Zhengwang Chen\|Liangxian Liu\|Wei Zeng\|Huanfeng Jiang\|
22	Cu(II)-catalyzed synthesis of naphthalene-1,3-diamine derivatives from haloalkynes and amines	期刊论文	刘良先\|
23	Silver-catalyzed highly regioselective synthesis of a-carbonyl furans from enynones	期刊论文	Dong-Nai Ye\|Zhong-Gao Zhou\|Min Ye\|Liang-Xian Liu\|
24	RuCl3-DCHA CatalystSystem: A Selective Aerobic Oxidation of Primary Benzylic Alcohols under Mild Conditions	期刊论文	Lei Shu\|Shiyong Zhang\|Qiaosheng Hu\|Liangxian Liu\|
25	One-pot synthesis of bis(indolyl)methanes: ruthenium-catalyzed reaction of benzylic alcoholes and indoles	期刊论文	刘良先\|
26	TEMPO and its derivatives: synthesis and applications	期刊论文	Zhonggao Zhou\|Liangxian Liu\|
27	5-硝基呋喃亚胺化合物的合成及抗血吸虫活性研究	期刊论文	屈红恩\|昌琼\|陈正旺\|刘良先\|
28	Highly regioselectivearylation of 1,2,3-triazole N-oxides withsodium arenesulfinates via palladium-catalyzeddesulfitative cross-coupling reaction	期刊论文	F. Lin\|B.-S. Wang\|Q. Huang\|L.-X. Liu\|
29	NiSO4-Catalyzed C-H Activation/C-S Cross-Coupling of 1,2,3-Triazole N-Oxides with Thiols	期刊论文	Feng Lin\|Baoshuang Wang\|Zhengwang Chen\|Liangxian Liu\|
30	Three-component, four-molecule, Ru-catalyzed cascade reactions of indoles and alkyl bromides with sodium nitrite	期刊论文	Jiuling Li\|Huiliang Li\|Hengshan Wang\|Liangxian Liu\|

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