GLP-1受体的液体核磁共振研究

31971153
2019
C0509.生物学过程与代谢
刘东升
面上项目
副研究员
上海科技大学
58万元
蛋白质;瞬态结构;核磁共振;构象选择;顺磁核磁
2020-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 G Protein-coupled Receptor (GPCR) Reconstitution and Labeling for Solution Nuclear Magnetic Resonance (NMR) Studies of the Structural Basis of Transmembrane Signaling 期刊论文 Haoyi Ge;Huixia Wang;Benxun Pan;Dandan Feng;Canyong Guo;Lingyun Yang;Dongsheng Liu;Kurt Wüthrich
2 GPCR large-amplitude dynamics by 19F-NMR of aprepitant bound to the neurokinin 1 receptor 期刊论文 Benxun Pan;Dongsheng Liu;Lingyun Yang;Kurt Wüthrich
3 Two-Dimensional NMR Spectroscopy of the G Protein-Coupled Receptor A2AAR in Lipid Nanodiscs 期刊论文 Canyong Guo;Canyong Guo;Zhijun Liu;Dongsheng Liu;Kurt Wüthrich
4 GPCR structural characterization by NMR spectroscopy in solution 期刊论文 Lingyun Yang;Dongsheng Liu;Kurt Wüthrich
5 Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by 19F-NMR and cryo-electron microscopy 期刊论文 Yanliu Fan;Xi Lin;Benxun Pan;Bo Chen;Dongsheng Liu;Kurt Wüthrich;Fei Xu
6 Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR 期刊论文 Huixia Wang;Wanhui Hu;Tiandan Xu;Ya Yuan;Dongsheng Liu;Kurt Wüthrich
7 Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for F-19-NMR studies in solution 期刊论文 Wang Huixia;Hu Wanhui;Liu Dongsheng;Wuthrich Kurt
8 A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1 期刊论文 Xiaoyan Wang;Dongsheng Liu;Ling Shen;Fahui Li;Yongze Li;Lingyun Yang;Tiandan Xu;Houchao Tao;Deqiang Yao;Lijie Wu;Kunio Hirata;Laura M Bohn;Alexandros Makriyannis;Xiaohong Liu;Tian Hua;Zhi-Jie Liu;Jiangyun Wang
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