针对乳腺癌靶点HER2激酶高活性高选择性抑制剂的发现研究

81803366
2018
H3401.合成药物化学
王傲莉
青年科学基金项目
副研究员
中国科学院合肥物质科学研究院
21万元
不可逆结合;激酶抑制剂;乳腺癌;HER2激酶
2019-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Discovery of a highly potent and selective Bruton’s tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma 期刊论文 Juan Liu;Qianmao Liang;Aoli Wang;Fengming Zou;Ziping Qi;Kailin Yu;Qingwang Liu;Cheng Chen;Jing Liu;Qingsong Liu
2 Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease 期刊论文 王傲莉
3 Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models 期刊论文 Wang Li;Hu Chen;Wang Aoli;Chen Cheng;Wu Jiaxin;Jiang Zongru;Zou Fengming;Yu Kailin;Wu Hong;Liu Juan;Wang Wenliang;Wang Zuowei;Wang Beilei;Qi Ziping;Liu Qingwang;Wang Wenchao;Li Lili;Ge Jian;Liu Jing;Liu Qingsong
4 Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia 期刊论文 Chen Hu;Fengming Zou;Aoli Wang;Weili Miao;Qianmao Liang;Ellen L. Weisberg;Yinsheng Wang;Jing Liu;Wenchao Wang;Qingsong Liu
5 Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl) acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文 Liang Xiaofei;Wang Beilei;Chen Cheng;Wang Aoli;Hu Chen;Zou Fengming;Yu Kailin;Liu Qingwang;Li Feng;Hu Zhenquan;Lu Tingting;Wang Junjie;Wang Li;Weisberg Ellen L;Li Lili;Xia Ruixiang;Wang Wenchao;Ren Tao;Ge Jian;Liu Jing;Liu Qinsong
6 All-trans retinoic acid exerts selective anti-FLT3-ITD acute myeloid leukemia efficacy through downregulating Chk1 kinase 期刊论文 Wang Wenliang;Jiang Zongru;Wang Li;Wang Aoli;Liu Juan;Chen Cheng;Yu Kailin;Zou Fengming;Wang Wenchao;Liu Jing;Liu Qingsong
7 Discovery of 2-(4-chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl )oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors 期刊论文 Wu Yun;Wang Beilei;Wang Junjie;Qi Shuang;Zou Fengming;Qi Ziping;Liu Feiyang;Liu Qingwang;Chen Cheng;Hu Chen;Hu Zhenquan;Wang Aoli;Wang Li;Wang Wenchao;Ren Tao;Cai Yujiao;Bai Mingfeng;Liu Qingsong;Liu Jing
8 Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52 期刊论文 Wang Wen-liang;Jiang Zong-ru;Hu Chen;Chen Cheng;Hu Zhen-quan;Wang Ao-li;Wang Li;Liu Jing;Wang Wen-chao;Liu Qing-song
9 Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent 期刊论文 Jiang Zongru;Wang Li;Liu Xuesong;Chen Cheng;Wang Beilei;Wang Wenliang;Hu Chen;Yu Kailin;Qi Ziping;Liu Qingwang;Wang Aoli;Liu Jing;Hong Guangchen;Wang Wenchao;Liu Qingsong
10 针对白血病的创新靶向药物设计新策略 奖励 刘青松;刘静;吴宏;王傲莉;李希祥
11 Discovery of (E)-N-1-(3-Fluorophenyl)-N-3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl) malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) 期刊论文 Liu Xuesong;Wang Beilei;Chen Cheng;Qi Ziping;Zou Fengming;Wang Junjie;Hu Chen;Wang Aoli;Ge Juan;Liu Qingwang;Yu Kailin;Hu Zhenquan;Jiang Zongru;Wang Wei;Wang Li;Wang Wenchao;Ren Tao;Bai Mingfeng;Liu Qingsong;Liu Jing
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