Trametinib克服ALK耐药性突变的机制研究
81673469
2016
H3505.抗肿瘤药物药理
王文超
面上项目
研究员
中国科学院合肥物质科学研究院
54万元
MEK激酶;高通量筛选;肿瘤耐药性;抑制剂;曲美替尼
2017-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Discovery of (E)-N-1-(3-Fluorophenyl)-N-3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl) malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) | 期刊论文 | Liu Xuesong;Wang Beilei;Chen Cheng;Qi Ziping;Zou Fengming;Wang Junjie;Hu Chen;Wang Aoli;Ge Juan;Liu Qingwang;Yu Kailin;Hu Zhenquan;Jiang Zongru;Wang Wei;Wang Li;Wang Wenchao;Ren Tao;Bai Mingfeng;Liu Qingsong;Liu Jing |
| 2 | Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway | 期刊论文 | Chen Cheng;Cheng Chuan-dong;Wu Hong;Wang Zuo-wei;Wang Li;Jiang Zong-ru;Wang Ao-li;Hu Chen;Dong Yong-fei;Niu Wan-xiang;Qi Shuang;Qi Zi-ping;Liu Jing;Wang Wen-chao;Niu Chao-shi;Liu Qing-song |
| 3 | Discovery of 2-(4-chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl )oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors | 期刊论文 | Wu Yun;Wang Beilei;Wang Junjie;Qi Shuang;Zou Fengming;Qi Ziping;Liu Feiyang;Liu Qingwang;Chen Cheng;Hu Chen;Hu Zhenquan;Wang Aoli;Wang Li;Wang Wenchao;Ren Tao;Cai Yujiao;Bai Mingfeng;Liu Qingsong;Liu Jing |
| 4 | Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52 | 期刊论文 | Wang Wen-liang;Jiang Zong-ru;Hu Chen;Chen Cheng;Hu Zhen-quan;Wang Ao-li;Wang Li;Liu Jing;Wang Wen-chao;Liu Qing-song |
| 5 | Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models | 期刊论文 | Wang Li;Hu Chen;Wang Aoli;Chen Cheng;Wu Jiaxin;Jiang Zongru;Zou Fengming;Yu Kailin;Wu Hong;Liu Juan;Wang Wenliang;Wang Zuowei;Wang Beilei;Qi Ziping;Liu Qingwang;Wang Wenchao;Li Lili;Ge Jian;Liu Jing;Liu Qingsong |
| 6 | Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models | 期刊论文 | Lu Tingting;Chen Cheng;Wang Aoli;Jiang Zongru;Qi Ziping;Hu Zhenquan;Hu Chen;Liu Feiyang;Wang Wenliang;Wu Hong;Wang Beilei;Wang Li;Qi Shuang;Wu Jiaxin;Wang Wenchao;Tang Jun;Yan Hezhong;Bai Mingfeng;Liu Qingsong;Liu Jing |
| 7 | Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent | 期刊论文 | Jiang Zongru;Wang Li;Liu Xuesong;Chen Cheng;Wang Beilei;Wang Wenliang;Hu Chen;Yu Kailin;Qi Ziping;Liu Qingwang;Wang Aoli;Liu Jing;Hong Guangchen;Wang Wenchao;Liu Qingsong |
| 8 | Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl) acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia | 期刊论文 | Liang Xiaofei;Wang Beilei;Chen Cheng;Wang Aoli;Hu Chen;Zou Fengming;Yu Kailin;Liu Qingwang;Li Feng;Hu Zhenquan;Lu Tingting;Wang Junjie;Wang Li;Weisberg Ellen L;Li Lili;Xia Ruixiang;Wang Wenchao;Ren Tao;Ge Jian;Liu Jing;Liu Qinsong |
| 9 | Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia | 期刊论文 | Chen Cheng;Wang Li;Li Lili;Wang Aoli;Huang Tao;Hu Jie;Zhao Ming;Liu Feiyang;Qi Shuang;Hu Chen;Wang Wenliang;Liu Jing;Ge Jian;Xia Ruixiang;Wang Wenchao;Liu Qingsong |
| 10 | Axitinib overcomes multiple imatinib resistant cKIT mutations including the gatekeeper mutation T670I in gastrointestinal stromal tumors | 期刊论文 | Liu Feiyang;Zou Fengming;Chen Cheng;Yu Kailin;Liu Xiaochuan;Qi Shuang;Wu Jiaxin;Hu Chen;Hu Zhenquan;Liu Juan;Liu Xuesong;Wang Li;Ge Juan;Wang Wenchao;Ren Tao;Bai Mingfeng;Cai Yujiao;Xiao Xudong;Qian Feng;Tang Jun;Liu Qingsong;Liu Jing |
| 11 | All-trans retinoic acid exerts selective anti-FLT3-ITD acute myeloid leukemia efficacy through downregulating Chk1 kinase | 期刊论文 | Wang Wenliang;Jiang Zongru;Wang Li;Wang Aoli;Liu Juan;Chen Cheng;Yu Kailin;Zou Fengming;Wang Wenchao;Liu Jing;Liu Qingsong |
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