基于天然活性分子LX0278为探针的胰岛素增敏新信号转导通路的发现

90713046
2007
B0706.药物化学生物学
沈旭
重大研究计划
教授
中国科学院上海药物研究所
240万元
胰岛素;2型糖尿病;药物设计;探针分子;葡萄糖转运蛋白
2008-01-01到2011-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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2 2,2‘, 4’ -trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice 期刊论文 Wang X|Jiang H|Zhu Z|Hu L|Shen X| Yang Z|Chen J|Li C|
3 Structural basis for retinoic X receptor repression on the tetramer 期刊论文 Zhang H|Chen L|Shen X|Jiang H|Chen J|
4 The catalytic intermediate stabilized by a “down” active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis 期刊论文 Jiang H|Ding J|Hu T|Chen J|Shen X|Wu D|
5 Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode 期刊论文 Zhang H|Hu L|Jiang H|Li L|Shen X|Chen L|
6 Molecular basis of recognition of human osteopontin by 23C 3, a potential therapeutic antibody for treatment of rheumatoid arthritis 期刊论文 Jianxin Dai|Jiamu Du|Dapeng Zhang|Sheng Hou|Hui Yang|Hao Wang|Zheng Lai|Jianping Ding| Yajun Guo|Chen Zhong|
7 Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism 期刊论文 Hu L|Lin Z|Zhang Y|Shen H|Zhang Y|Jiang H|Shen X|
8 Structural determinants of an insect beta-N-Acetyl-D-hexosaminidase specialized as a chitinolytic enzyme 期刊论文 Liu F|Wu Q|Liu T|Shen X| Yang Q|Zhang H|
9 Efalizumab binding to the LFA-1 aL I domain blocks ICAM-1 binding via steric hindrance 期刊论文 Jianping Ding|Hao Wang|Daipong Zhang|Sheng Li|Baozhen Peng|Sheng Hou|Meilan Zhang|Yajun Guo|
10 Structural basis of the immunosuppressive mechanism of therapeutic antibody daclizumab 期刊论文 Jianping Ding| Huaizu Guo|Jianchuan Wang| Yajun Guo|Dapeng Zhang|Jiamu Du|Chen Zhong|Hui Yang|
11 Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C -like protease: crystal structure with molecular dynamics simulations 期刊论文 Ding J|Zhang J|Chen J|Chen S|Chen K|Jiang H|Hu T|Shen X|
12 Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination 期刊论文 Li H|Zhang L|He L|Shen X|Liu H|Zheng M|Yu K|Chen K|Jiang H|Liu X|Li X|
13 Activation of protein serine/threonine phosphatase PP2Cα efficiently prevents liver fibrosis 期刊论文 Chen J|Yang Z|Hu L|Shen X|Wang L|Wang X|Yu L|
14 Structural basis for the blockage of IL-2 signaling by therapeutic antibody Basiliximab 期刊论文 Jianchuan Wang|Jianping Ding|Dapeng Zhang|Baozhen Peng|Huaizu Guo|Jiamu Du|Hui Yang|Yajun Guo|
15 Isoquinoline-1,3,4-trione derivatives inactivates caspase-3 by generation of reactive oxygen species 期刊论文 Jian Wu|Junqing Du|Huajie Zhang|Jianping Ding|Beiying Qiu|Fang Wu|Jingya Li|Fajun Nan|Yihua Chen| Yahui Zhang|
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