设计合成新颖的MAP3K14激酶抑制剂和降解剂，研究其生物活性和成药性

81872724
2018
H3401.合成药物化学
赵玉军
面上项目
研究员
中国科学院上海药物研究所
57万元
NIK;MAP3K14;激酶抑制剂;蛋白质降解;NF-κB2
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). 期刊论文 Zhang Shiyan;Huang Chaoying;Lyu Xilin;Wang Peipei;Zang Yi;Wang Zengtao;Wang Huan;Li Jia;Zhao Yujun
2 Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo. 期刊论文 Li Zhiqiang;Li Xinzhi;Su Ming-Bo;Gao Li-Xin;Zhou Yu-Bo;Yuan Bingchuan;Lyu Xilin;Yan Ziqin;Hu Chujiao;Zhang Hao;Luo Cheng;Chen Zheng;Li Jia;Zhao Yujun
3 Pharmacological inhibition of NF-kappa B-inducing kinase (NIK) with small molecules for the treatment of human diseases 期刊论文 Cheng Jing;Feng Xuexin;Li Zhiqiang;Zhou Feilong;Yang Jin-Ming;Zhao Yujun
4 Discovery of pyrrolo[3,2-d]pyrimidine-containing compounds as inhibitors of NIK kinase 会议论文 Yujun Zhao;Zhiqiang Li;Ziqing Yan;Xilin Lv
5 一种具有2-氨基嘧啶结构的化合物,其制备方法和用途 专利 赵玉军;李志强;严子琴;李佳;周宇波;苏明波;陈政
6 Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein–Protein Interactions 期刊论文 Zhang Shiyan;Lou Jianfeng;Li Yafang;Zhou Feilong;Yan Ziqin;Lyu Xilin;Zhao Yujun
7 Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes 期刊论文 Li Xinzhi;Wu Yongsen;Song Yue;Ding Na;Lu Min;Jia Linna;Zhao Yujun;Liu Ming;Chen Zheng
8 Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells 期刊论文 Zhang Shiyan;Yan Ziqin;Li Yafang;Gong Yang;Lyu Xilin;Lou Jianfeng;Zhang Daizhou;Meng Xiangjing;Zhao Yujun
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